Studies on the Enhancement of Radiocalcium and Radiostrontium Absorption by Lactose in the Rat

Lengemann, F. W.; Wasserman, R. H.; Comar, C. L.

doi:10.1093/jn/68.3.443

Cited by 84 publications

(20 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lactose has been found to enhance the absorption of calcium (Ca) from the digestive tract in a variety of species, including rats (Lengemann et al, 1959), chicks (Kline et al, 1932), dairy calves (Robinson et al, 1929) and humans (Kobayashi et al, 1975). Limited research in this area has been conducted with swine.…”

Section: Introductionmentioning

confidence: 99%

Effect of Dietary Lactose on Gain, Feed Conversion, Blood, Bone and Intestinal Parameters in Postweaning Rats and Swine

Moser

Peo

Crenshaw

et al. 1980

Journal of Animal Science

View full text Add to dashboard Cite

SummaryTwo trials were conducted to determine the effect of lactose on performance, bone integrity and certain blood constituents in postweaning rats and swine. The effect of lactose on calcium and phosphorus and percentage ash content of the small intestine was also determined. In both trials, average daily gains were not influenced by the feeding of diets containing 30% lactose. Feed conversion was depressed in both rats and pigs when 30% lactose was fed. Transitory diarrhea was observed in rats fed 30% lactose, but not in swine. In the rat trial, no significant differences due to treatment were observed for serum Ca or P, but a linear increase (P<.01) in alkaline phosphatase was observed as lactose increased in the diet. Analysis of blood constituents from multiple bleedings during the pig trial showed that in the first 2 weeks, alkaline phosphatase was increased (P<.O1) in pigs fed lactose and slightly decreased in those not fed lactose. Lactose affected the change in serum Ca from 0 to 10 weeks (P<.05) as indicated by a marked reduction in serum Ca of pigs not fed lactose and a slight increase for those fed lactose. Serum calcium decreased in the absence of lactose but increased in the presence of lactose (P<.05) in pigs fed .4% Ca diets. In both trials, breaking strength parameters (peak force and stress) were not affected by dietary lactose. Bones from pigs fed no lactose had a higher stress to strain ratio (P<.05) than those from pigs fed lactose.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of Dietary Lactose on Gain, Feed Conversion, Blood, Bone and Intestinal Parameters in Postweaning Rats and Swine

Moser

Peo

Crenshaw

et al. 1980

Journal of Animal Science

View full text Add to dashboard Cite

show abstract

“…Dietary factors that have been shown to affect Ca 2ϩ bioavailability include plant fiber, fat, phosphorus, protein, and carbohydrate (1,2,9,35). Concerning potential interactions between intestinal carbohydrate and Ca 2ϩ absorption, most investigations have focused on the stimulating effect of the milk sugar lactose on the absorption of Ca 2ϩ (3,14,27,51,52), as these two nutrients are typically in the intestinal lumen at the same time. Moreover, monosaccharides such as glucose and/or galactose have also been reported to acutely affect intestinal Ca 2ϩ transport (11,60,69,75).…”

mentioning

confidence: 99%

Acute interactions between intestinal sugar and calcium transport in vitro

Tharabenjasin

Douard

Patel

et al. 2014

American Journal of Physiology-Gastrointestinal and Liver Physi

View full text Add to dashboard Cite

Fructose consumption by Americans has increased markedly, whereas Ca2+ intake has decreased below recommended levels. Because fructose metabolism decreases enterocyte ATP concentrations, we tested the hypothesis that luminal fructose acutely reduces active, diet-inducible Ca2+ transport in the small intestine. We confirmed that the decrease in ATP concentrations was indeed greater in fructose- compared with glucose-incubated mucosal homogenates from wild-type and was prevented in fructose-incubated homogenates from ketohexokinase (KHK)−/− mice. We then induced active Ca2+ transport by chronically feeding wild-type, fructose transporter glucose transporter 5 (GLUT5)−/−, as well as KHK−/− mice a low Ca2+ diet and measured transepithelial Ca2+ transport in everted duodenal sacs incubated in solutions containing glucose, fructose, or their nonmetabolizable analogs. The diet-induced increase in active Ca2+ transport was proportional to dramatic increases in expression of the Ca2+-selective channel transient receptor potential vanilloid family calcium channel 6 as well as of the Ca2+-binding protein 9k (CaBP9k) but not that of the voltage-dependent L-type channel Ca(v)1.3. Crypt-villus distribution of CaBP9k seems heterogeneous, but low Ca2+ diets induce expression in more cells. In contrast, KHK distribution is homogeneous, suggesting that fructose metabolism can occur in all enterocytes. Diet-induced Ca2+ transport was not enhanced by addition of the enterocyte fuel glutamine and was always greater in sacs of wild-type, GLUT5−/−, and KHK−/− mice incubated with fructose or nonmetabolizable sugars than those incubated with glucose. Thus duodenal Ca2+ transport is not affected by fructose and enterocyte ATP concentrations but instead may decrease with glucose metabolism, as Ca2+ transport remains high with 3- O-methylglucose that is also transported by sodium-glucose cotransporter 1 but cannot be metabolized.

show abstract

“…Milk casein phosphopeptides have been shown to have a positive effect on the absorption of calcium, in vivo and in vitro in rats with an increase in the intestinal transfer of calcium and, on bone metabolism [12,21,23,28,46,51,55]. Other in vivo studies on rats have demonstrated that lactose stimulates calcium absorption or retention by acting directly on the intestine, and on the bone [3,11,13,25,44]. There is also indirect in vitro evidence of the effect of lactose on calcium absorption from studies with isolated intestinal loops [2,10], where lactose was compared to another sugar and to a control without lactose [2].…”

Section: Discussionmentioning

confidence: 99%

Availability of calcium from skim milk, calcium sulfate and calcium carbonate for bone mineralization in pigs

Pointillart¹,

Coxam²,

Sève

et al. 2000

Reprod. Nutr. Dev.

View full text Add to dashboard Cite

-Dairy products provide abundant, accessible calcium for humans, while some calcium sulfate-rich mineral waters could provide appreciable amounts of calcium. But there is little evidence that this calcium is as available as milk calcium for making bone. The availability of calcium was studied by monitoring bone parameters in 2-month-old pigs fed restricted amounts of calcium (70% RDA) for 2.5 months. The 3 main (≥ 50% Ca intake) Ca sources were either CaCO 3 or CaSO 4 or skim milk powder (29% of the diet). The bones of the pigs fed the "milk" diet had higher (P < 0.01) ash contents, breaking strength and density (DEXA) than those of the two others groups, in which the bone values were similar. Thus, the calcium provided by a diet containing milk appears to ensure better bone mineralization than do calcium salts included in a non-milk diet. The calcium restriction may have enhanced some milk properties to stimulate calcium absorption in these young, rapidly growing pigs.calcium availability / calcium sulfate / milk calcium / bones / pigs Résumé -Biodisponibilité comparée du calcium du lait, du sulfate et du carbonate de calcium pour la minéralisation osseuse: étude chez le porc. Le sulfate de calcium, dont certaines eaux minérales sont riches, est-il aussi bien utilisé pour la minéralisation osseuse que le calcium des produits laitiers ? Trois lots de 8 porcs, de 2 mois, recevaient pendant 2,5 mois, trois régimes dont au moins 50 % de l'apport calcique était fourni par CaSO 4 , CaCO 3 ou la poudre de lait. Bien que différents dans leur composition, les trois régimes étaient formulés pour avoir la même valeur nutritionnelle et leur teneur en Ca était restreinte (70 % des recommandations). Avec le régime « lait », les cendres, la résistance à la rupture et la densité minérale des os étaient supérieures à celles des deux autres groupes, non différents l'un de l'autre. L'analyse des paramètres circulants liés au métabolisme osseux (en particulier au collagène), des 3 groupes, exclut l'hypothèse d'un effet direct de la source Reprod. Nutr. Dev. 40 (2000) 49-61 49

show abstract

Studies on the Enhancement of Radiocalcium and Radiostrontium Absorption by Lactose in the Rat

Cited by 84 publications

References 9 publications

Effect of Dietary Lactose on Gain, Feed Conversion, Blood, Bone and Intestinal Parameters in Postweaning Rats and Swine

Effect of Dietary Lactose on Gain, Feed Conversion, Blood, Bone and Intestinal Parameters in Postweaning Rats and Swine

Acute interactions between intestinal sugar and calcium transport in vitro

Availability of calcium from skim milk, calcium sulfate and calcium carbonate for bone mineralization in pigs

Contact Info

Product

Resources

About