Studies on the Epidemiology and Pathogenesis of Alphaherpesviruses from Red Deer (Cervus Elaphus) and Reindeer (Rangifer Tarandus)

Nettleton, PF; Ek-Kommonen, Christine; Tanskanen, Raili; Reid, HW; Sinclair, JA; Herring, J. A.

doi:10.1007/978-94-009-1325-7_16

Cited by 16 publications

(25 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In 1982, a prevalence of 23% reindeer seropositive to BoHV-1 was observed in the Finnish Lapland [33]. In Finland, 64% of adult reindeer and 1% of calves have been shown to be seropositive to CvHV-2 [87]. A Norwegian investigation showed similar results: 60% of reindeer and 15% of calves were shown to be seropositive [55].…”

Section: Cervid Herpesvirusmentioning

confidence: 97%

“…Therefore, CvHV-2 most likely establishes a latent infection and can be re-excreted in genital secretions. A serological investigation showing a high prevalence in adult reindeer suggests genital transmission [87].…”

Section: Cervid Herpesvirusmentioning

confidence: 99%

“…Seroconversions to BoHV-1 in red deer do not occur and are most likely the result of a CvHV-1 rather than BoHV-1 infection [86,99]. Another deer species, the mule deer (Odocoileus hemionus), exhibits greater susceptibility to BoHV-1 because it actively excretes BoHV-1 and shows seroconversion after experimental inoculation [87].…”

Section: Bovine Herpesvirus 1 Infection Of Red Deer and Reindeermentioning

confidence: 99%

“…The virus is isolated for six to nine days from nasal and genital swabs [87]. Therefore, CvHV-2 replication can occur experimentally in bovines, but cattle housed in close contact with infected reindeer are not infected [34].…”

Section: Cervid Herpesvirus 2 Infection Of Calvesmentioning

confidence: 99%

See 3 more Smart Citations

Ruminant alphaherpesviruses related to bovine herpesvirus 1

et al. 2006

View full text Add to dashboard Cite

-Herpesviruses have mainly co-evolved with their hosts for millions of years. Consequently, different related host species may have been infected by various genetically related herpesviruses. Illustrating this concept, several ruminant alphaherpesviruses have been shown to form a cluster of viruses closely related to bovine herpesvirus 1 (BoHV-1): namely bovine herpesvirus 5, bubaline herpesvirus 1, caprine herpesvirus 1, cervid herpesviruses 1 and 2 and elk herpesvirus 1. These viruses share common antigenic properties and the serological relationships between them can be considered as a threat to BoHV-1 eradication programmes. BoHV-1 is a herpesvirus responsible for infectious bovine rhinotracheitis, which is a disease of major economic concern. In this article, the genetic properties of these ruminant alphaherpesviruses are reviewed on a comparative basis and the issue of interspecific recombination is assessed. The pathogenesis of these infections is described with emphasis on the host range and crossing of the host species barrier. Indeed, the non bovine ruminant species susceptible to these ruminant alphaherpesviruses may be potential BoHV-1 reservoirs. The differential diagnosis of these related infections is also discussed. In addition, available epidemiological data are used to assess the potential of cross-infection in ruminant populations. A better knowledge of these ruminant alphaherpesvirus infections is essential to successfully control infectious bovine rhinotracheitis.

show abstract

Section: Cervid Herpesvirusmentioning

confidence: 97%

Section: Cervid Herpesvirusmentioning

confidence: 99%

Section: Bovine Herpesvirus 1 Infection Of Red Deer and Reindeermentioning

confidence: 99%

Section: Cervid Herpesvirus 2 Infection Of Calvesmentioning

confidence: 99%

See 2 more Smart Citations

Ruminant alphaherpesviruses related to bovine herpesvirus 1

et al. 2006

View full text Add to dashboard Cite

show abstract

“…In this context, two potential risks need to be accounted for: infection of cattle with heterologous ruminant alphaherpesviruses closely related to BoHV-1 and interspecific recombination between BoHV-1 and related viruses, which could hamper infectious bovine rhinotracheitis eradication programs with BoHV-1 live marker vaccines. Infection of cattle with heterologous ruminant alphaherpesviruses has been demonstrated (41,54,59,62,63), whereas there is no evidence of interspecific recombination between ruminant alphaherpesviruses.…”

mentioning

confidence: 99%

Interspecific Recombination between Two Ruminant Alphaherpesviruses, Bovine Herpesviruses 1 and 5

Meurens

Keil

Muylkens

et al. 2004

J Virol

View full text Add to dashboard Cite

Homologous recombination between different species of alphaherpesviruses has been described between herpes simplex viruses 1 and 2 but has not yet been observed between other alphaherpesviruses. In the present study we chose to assess to what extent in vitro recombination can occur between members of a well-defined group of closely related viruses such as ruminant alphaherpesviruses. At 24 h after infection of epithelial bovine kidney cells with a double-deleted mutant of bovine herpesvirus 1 (BoHV-1) (containing green fluorescent protein and red fluorescent protein genes) and different ruminant alphaherpesviruses, four types of progeny viruses were detected and distinguished according to their phenotype. Frequent recombination events between identical or different strains of BoHV-1 were observed (up to 30%), whereas only two BoHV-1/BoHV-5 recombinants were identified, and no recombinants between BoHV-1 and less closely related caprine and cervine herpesviruses were detected. Restriction analysis of the genomes of the two BoHV-1/BoHV-5 recombinants showed different genetic backgrounds. One possessed a restriction pattern close to BoHV-1, whereas the other one was close to BoHV-5. This exhaustive analysis of each combination of coinfection in a unique situation of five closely related alphaherpesviruses revealed the importance of a high degree of genetic relatedness and similar parental virus growth kinetics for successful interspecific recombination.

show abstract