Studies on the Etiology of Epidemic Keratoconjunctivitis*

Jawetz, Ernest; Kimura, Samuel J.; Hanna, Lavelle; Coleman, Virginia R.; Thygeson, Phillips; Nicholas, A.

doi:10.1016/0002-9394(55)91856-0

Cited by 66 publications

(17 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subsequently, due to its epidemic nature, the illness was called 'epidemic keratoconjunctivitis' (EKC) (Hogan & Crawford, 1942). The disease was characterized by severe bilateral conjunctivitis with a painful and distressing keratitis, severe photophobia and corneal opacities with variable degree of visual impairment for months to years (Jawetz et al, 1955a(Jawetz et al, , 1955b(Jawetz et al, , 1957. EKC was also described among German workers in the late 19th century.…”

Section: Journal Of Medical Microbiology 61mentioning

confidence: 99%

Human adenovirus type 8 genome typing

Adhikary

Ushijima

Fujimoto

2012

Journal of Medical Microbiology

View full text Add to dashboard Cite

Section: Journal Of Medical Microbiology 61mentioning

confidence: 99%

Human adenovirus type 8 genome typing

Adhikary

Ushijima

Fujimoto

2012

Journal of Medical Microbiology

View full text Add to dashboard Cite

“…In 1955 the causative organism was identified as an adenovirus (Jawetz et al, 1955), and since that time several different adenovirus serotypes have been shown to cause conjunctivitis with and without corneal involvement (Grayston et al, 1964). An outbreak in Bristol in 1971 caused by adenovirus type 8 has been described previously (Barnard et al, 1973), and isolated cases and small outbreaks resulting from infections with types 10 and 19 have been diagnosed elsewhere (Heubner and Rowe, 1957;Desmyter et al, 1974;Burns and Potter, 1976;O'Day et al, 1976;Darougar et al, 1977;Zografos, 1977).…”

mentioning

confidence: 99%

An outbreak of adenovirus keratoconjunctivitis in bristol.

Tullo¹,

Higgins²

1979

British Journal of Ophthalmology

View full text Add to dashboard Cite

“…In Western countries adenoviral conjunctivitis is frequently reported as swimming pool conjunctivitis or nosocomial conjunctivitis. Certain members of subgenus D, namely the Ad8, Ad19a, and Ad37, cause outbreaks of keratoconjunctivitis and rapid identification of these serotypes can help in prevention and control [Jawetz et al, 1955;Darougar et al, 1977;Kemp et al, 1983].…”

Section: Introductionmentioning

confidence: 99%

Molecular epidemiology of adenovirus strains isolated from patients with ocular disease in the area of Thessaloniki, Greece (1998-2002)

et al. 2005

View full text Add to dashboard Cite

Thirty strains of adenovirus (Ads) associated with ocular disease have been isolated over a period of 4 years in Thessaloniki, Northern Greece. Eleven strains were isolated from sporadic patients with conjunctivitis or keratoconjunctivitis in Thessaloniki city between 1998 and 2000. Nineteen strains were isolated from patients with keratoconjunctivitis during an outbreak of Ads in the area of Thessaloniki (Thessaloniki and Serres cities) in 2002. PCR-sequence method using primers targeted against the hypervariable regions (HVRs) of hexon gene, as well as the neutralization test were used for typing the Ad isolates and assessing a possible relation among these strains, and their genetic variability. Ad4 with very close homology to variant Z-G 95-873 was the most frequent genotype causing sporadic conjunctivitis over a period of 4 years. Two other strains, one Ad2, and one Ad3 were similar to the prototype ones, and a third one shows close homology to the variant of prototype Ad15, the Morrison strain. The genome typing of twenty two Ad8 isolates showed very close homology in their amino acid and nucleotide sequences to the variant of Ad8, strain 1127 (accession no. X74663). Four were isolated from patients with keratoconjunctivitis in 1998, 1999, 2000 and 18 during the outbreak in 2002. As far as strain 1127 is concerned, all the Ad8 isolates showed the same changes in the HVR 1 and HVR 2 except one isolate in 1998, which showed some changes outside the HVRs. During the outbreak of Ad8 keratoconjunctivitis, it was not possible to identify the exact source of infection (nosocomial or/and outpatients). Finally, Ad4 variant Z-G 95-873 and Ad8 which is closely related to the strain 1127, were found to be the predominant adenoviruses circulating in Northern Greece during 1998-2002.

show abstract

Studies on the Etiology of Epidemic Keratoconjunctivitis*

Cited by 66 publications

References 10 publications

Human adenovirus type 8 genome typing

Human adenovirus type 8 genome typing

An outbreak of adenovirus keratoconjunctivitis in bristol.

Molecular epidemiology of adenovirus strains isolated from patients with ocular disease in the area of Thessaloniki, Greece (1998-2002)

Contact Info

Product

Resources

About