Studies on the etiology of the experimental neuropathy from industrial adhesive (glues)

Franchini, I; Cavatorta, A; D’Errico, Marcello Mario; Santis, M De; Romita, G; Gatti, Rita; Juvarra, G; Palla, Gerardo

doi:10.1007/bf01944708

Cited by 9 publications

(4 citation statements)

References 9 publications

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“…Potassium dichromate is a formula of chromium and it has stayed used in the induction of hepaticinjury [10][11][12][13] . And it is described that acute contact encourageshepatic structural alterationin the hepatocytes and phospholipid oxidation in the liver 13 .…”

Section: Discussionmentioning

confidence: 99%

Whey Protein and Nigella sativa Oil Mitigate Potassium Dichromate Induced Hepatic Injury, Oxidative Stress and Hematotoxicity in Rats

Bashandy¹,

Amin²,

El-Marasy³

et al. 2018

Asian Journal of Chemistry and Pharmaceutical Sciences

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The present study was carried out to evaluate the antioxidant property of whey protein and/or Nigella sativa Oil (NSO) against hepatotoxicity evoked by potassium dichromate(K 2 Cr 2 O 7 ). Designed for this purpose, we detected the 8 weeks challenge result of whey protein (100 and 200 mg/kg, p.o) with/or without Nigella sativa oil (5ml/kg, p.o) in contradiction of poisoned albino rats with one dose of potassium dichromate (30mg/Kg, I.P) at the end of challenge period. Concerning plasma level, whey protein with/or without Nigella sativa oil were ameliorated the potassium dichromate liver damage concerns, so it exhibited a major progress in Aspartate Aminotransferase (AST), Alanine Amino Transferase (ALT), Alkaline Phosphatase (ALP), and Gamma-Glutamyl Transferase (GGT). Moreover, whey protein or Nigella sativa oil reduce the deleterious effects of potassium dichromate on Triiodothyronine (T3), Thyroxine (T4), Thyroidstimulating Hormone (TSH), glucose and Complete Blood Count (CBC). In addition, they displayed an important improvement in hepatic antioxidant enzymes, Catalase (CAT) and Superoxide Dismutase (SOD) beside reduced Glutathione (GSH), and with a subsequent decrease in Malondialdehyde (MDA) or Nitric Oxide (NO) levels in comparison with the untreated K 2 Cr 2 O 7 group. Also, whey protein with/or without Nigella sativa oil improve the histopathological alterations produced by the potassium dichromate. These outcomes suggest that whey protein or Nigella sativa oil can be used as effective antioxidant aginst potassium dichromate intoxication as they modulate liver function and decrease oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Whey Protein and Nigella sativa Oil Mitigate Potassium Dichromate Induced Hepatic Injury, Oxidative Stress and Hematotoxicity in Rats

Bashandy¹,

Amin²,

El-Marasy³

et al. 2018

Asian Journal of Chemistry and Pharmaceutical Sciences

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“…It has been reported that peripheral neuropathy rate in abusers who inhale volatile substances varies between 7% and 62% depending on the substance content (Rosen 1984). Peripheral nerve toxicity of toluene could not be fully identified and has been reported to be at low rates (Franchini et al . 1978; Lolin 1989).…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, in some studies, peripheral neuropathy with motor dominance have been observed following toluene use in animal experiments and humans (Goto et al . 1974; Franchini et al . 1978; Streicher et al .…”

Section: Discussionmentioning

confidence: 99%

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Clinical, socio‐demographic, neurophysiological and neuropsychiatric evaluation of children with volatile substance addiction

Uzun

Kendirli

2005

Child

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In our study, neurophysiological and neuropsychiatric tests revealed that toluene causes slow progressive, clinical and subclinical central and peripheral nerve damage. In Turkey, because of cheapness, easy availability and legal use of volatile substances, the clinical extent of systemic and neurological toxicity of volatile substance abuse is increasing. Abuse of volatile substances, a currently increasing social issue, may create important physical problems which can be permanent.

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Absorption and alveolar excretion of cyclohexane in workers in a shoe factory

Mutti

Falzoi

Lucertini

et al. 1981

J of Applied Toxicology

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The lung uptake and excretion of cyclohexane were studied in five workers and three volunteers in a shoe factory. Air samples were collected from the breathing zones with personal samplers, and simultaneous samples of inhaled and alveolar air were collected with the aid of a Rhan-Otis valve. Cyclohexane was absorbed on activated NIOSH approved charcoal tubes. The uptake was calculated from the pulmonary ventilation, the retention coefficient and environmental concentration. Alveolar excretion was monitored during a 6 h post-exposure period. The amount of exhaled cyclohexane was calculated from the decay curve. According to experimental data, the alveolar retention of cyclohexane is about 34% of the inhaled dose. This corresponds to a lung uptake of 23%. The post-exposure alveolar excretion does not exceed 10% of the total uptake. The difference between respiratory uptake and excretion indicates that the amount metabolized may be very large. Nevertheless, the urinary excretion of the main metabolites, cyclohexanol and cyclohexanone, was only about 1% of the absorbed dose.

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Studies on the etiology of the experimental neuropathy from industrial adhesive (glues)

Cited by 9 publications

References 9 publications

Whey Protein and Nigella sativa Oil Mitigate Potassium Dichromate Induced Hepatic Injury, Oxidative Stress and Hematotoxicity in Rats

Whey Protein and Nigella sativa Oil Mitigate Potassium Dichromate Induced Hepatic Injury, Oxidative Stress and Hematotoxicity in Rats

Clinical, socio‐demographic, neurophysiological and neuropsychiatric evaluation of children with volatile substance addiction

Absorption and alveolar excretion of cyclohexane in workers in a shoe factory

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