Studies on the extended Techa river cohort: cancer risk estimation

Kossenko, M. M.; Preston, Dale L.; Krestinina, L. Yu.; Startsev, N. V.; Thomas, Terry L.; Vyushkova, O. V.; Anspaugh, L.R.; Napier, Bruce A.; Kozheurov, V. P.; Ron, Elaine; Akleyev, A. V.

doi:10.1007/s00411-001-0132-5

Cited by 23 publications

(15 citation statements)

References 8 publications

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“…The other subgroup consists of ''late entrants'', that is people who first came to live in one of the riverside villages between January 1, 1953 and December 31,1960. As described elsewhere (3)(4)(5)7), these popu- a Distant migrants are treated as lost to follow-up from the date of migration from the extended catchment area, which means that the total lost to follow-up is 7,023 (4,182 distant migrants and 2,841 lost to follow-up among extended catchment area residents) as of December 31, 1999. b Last known to be alive prior to December 31, 1999 and treated as lost to follow-up from date of last known vital status. lations were identified from various official documents (including taxation, vital statistics, and medical records) between the late 1960s and the 1980s.…”

Section: Cohort Definitionmentioning

confidence: 99%

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Protracted Radiation Exposure and Cancer Mortality in the Techa River Cohort

Preston²,

et al. 2005

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In the 1950s many thousands of people living in rural villages on the Techa River received protracted internal and external exposures to ionizing radiation from the release of radioactive material from the Mayak plutonium production complex. The Extended Techa River Cohort includes 29,873 people born before 1950 who lived near the river sometime between 1950 and 1960. Vital status and cause of death are known for most cohort members. Individualized dose estimates have been computed using the Techa River Dosimetry System 2000. The analyses provide strong evidence of long-term carcinogenic effects of protracted low-dose-rate exposures; however, the risk estimates must be interpreted with caution because of uncertainties in the dose estimates. We provide preliminary radiation risk estimates for cancer mortality based on 1,842 solid cancer deaths (excluding bone cancer) and 61 deaths from leukemia. The excess relative risk per gray for solid cancer is 0.92 (95% CI 0.2; 1.7), while those for leukemia, including and excluding chronic lymphocytic leukemia, are 4.2 (CI 95% 1.2; 13) and 6.5 (CI 95% 1.8; 24), respectively. It is estimated that about 2.5% of the solid cancer deaths and 63% of the leukemia deaths are associated with the radiation exposure.

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Section: Cohort Definitionmentioning

confidence: 99%

“…Information about the Techa River cohort was published in the open literature in the early 1990s (1)(2)(3)(4)(5)(6). Over the last decade, major improvements in the follow-up of the study population (7) and dosimetry have been made (8,9).…”

Section: Introductionmentioning

confidence: 98%

Protracted Radiation Exposure and Cancer Mortality in the Techa River Cohort

Preston²,

et al. 2005

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“…Of particular interest are those exposed to fallout from the early weapons tests at Semipalatinsk in Kazakhstan (Grosche et al, 2002) and residents of communities neighbouring the Techa River (Kossenko et al, 2002). The Techa River received large quantities of highly radioactive effluent from the Mayak nuclear complex in the early years of weapons plutonium production, especially during 1950-1952, leading to heavy contamination of the river and its environs.…”

Section: Introductionmentioning

confidence: 99%

The cancer epidemiology of radiation

2004

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“…Contamination of the components of the Techa River system (water, bottom sediments, floodplain soils, and floodplain grasses) resulted in chronic external and internal exposure of about 30,000 residents of riverside communities. The 90 Sr-intake function is a fundamental component of the dose-reconstruction system used for assessment of radiogenic health effects in the Techa Riverside residents (Degteva et al 2000a(Degteva et al , 2006Kossenko et al 2002;Krestinina et al 2005Krestinina et al , 2007.…”

Section: Introductionmentioning

confidence: 99%

Reconstruction of Long-Lived Radionuclide Intakes for Techa Riverside Residents: Strontium-90

Толстых¹,

Дегтева²,

Peremyslova³

et al. 2011

Health Physics

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Releases of radioactive materials from the Mayak Production Association in 1949-1956 resulted in contamination of the Techa River; a nuclide of major interest was 90Sr, which downstream residents consumed with water from the river and with milk contaminated by cows' consumption of river water and contaminated pasture. Over the years, several reconstructions of dose have been performed for the approximately 30,000 persons who make up the Extended Techa River Cohort. The purpose of the study described here was to derive a revised reference-90Sr-intake function for the members of this cohort. The revision was necessary because recently discovered data have provided a more accurate description of the time course of the releases, and more is now known about the importance of the pasture grass-cow-milk pathway for the members of this cohort. The fundamental basis for the derivation of the reference-90Sr-intake function remains the same: thousands of measurements of 90Sr content in bone with a special whole-body counter, thousands of measurements of beta-activity of front teeth with a special tooth-beta counter, and a variety of other measurements, including post mortem measurements of 90Sr in bone, measurements of 90Sr in cow's milk, and measurements of beta activity in human excreta. Results of the new analyses are that the major intake started in September 1950 and peaked somewhat later than originally postulated. However, the total intake for adult residents has not changed significantly. For children of some birth years, the intake and incorporation of Sr in bone tissue have changed substantially.

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Studies on the extended Techa river cohort: cancer risk estimation

Cited by 23 publications

References 8 publications

Protracted Radiation Exposure and Cancer Mortality in the Techa River Cohort

Protracted Radiation Exposure and Cancer Mortality in the Techa River Cohort

The cancer epidemiology of radiation

Reconstruction of Long-Lived Radionuclide Intakes for Techa Riverside Residents: Strontium-90

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