It is well know that non-premixed combustion is widely encountered in engine combustors. Presently Large-eddy simulation (LES) was used to study non-premixed combustion by many investigators using different combustion models. In this paper, the present authors used a second-order moment (SOM) combustion model for LES of propane-air swirling non-premixed combustion for the first time. The predicted time-averaged and RMS fluctuation velocities, time-averaged temperature and species concentration are in good agreement with experimental results, showing once again the feasibility of the SOM model. The instantaneous simulation results indicate the complex large-scale vortex structure and flame structure, different from those of the jet flame.