“…It is admitted that important aspects of the secretory phenomenon are incompletely understood and, in many respects, unknown; that points of view differ as to what does or does not constitite a secretion product, or even secretory activity versus pathologic degeneration; that it is not altogether evident where the line should be drawn, even for purposes of discussion, between secretory phenomena and those intracellular processes having to do with cell maintenance and differentiation phenomena of the cellular or protoplasmic units. Nevertheless, with a few doubtful exceptions as pointed out by Bowen (1929) and Dawson (1942) and others, a few tangible, morphologically discernible, and physiologically demonstrable features have evolved which are characteristic of secretory activity in its entirety as it is manifest by exocrine glands and the majority of another (Bowen, 1929;Dawson, 1942;Severinghaus, 1933;Saguchi, 1920;Hirsch, 1939;Hibbard, 1945;Gatenby, 1931;Lavdovsky, 1877;Caspersson, 1947). While no one would deny that secretory activity must depend upon the combined integrated functioning of all parts of the cell; e.g., nucleus, nucleoli, mitochondria, golgi complex, cytoplasmic ground substance, protoplasmic membranes, efc., it has not been possible, so far, to define clearly the particular role of each cellular component, if any, in the various phases of the secretory phenomenon.…”