Studies on the Hypotensive, Cardio-suppressant, Vasodilator and Antiplatelet Activities of Betel Nut Crude Extract and its Constituents

Gilani, Anwarul Hassan; Ghayur, N Muhammad; Houghton, Jack; Jabeen, Qaiser; Kazim, Farouk; Jumani, I Maliha; Saeed, AM

doi:10.3923/ijp.2006.33.41

Cited by 23 publications

(2 citation statements)

References 23 publications

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“…Ethanolic extracts of R. sativus leaves is identified with Sinapic acid which is considered as the main ingredient for anti-inflammatory effects. The addition of active fraction markedly inhibited LPS-stimulated production of inflammatory mediators by suppressing p38 Mitogen-activated protein kinase and nuclear factor-κB activation [25].…”

Section: Anti-inflammatory Activitymentioning

confidence: 94%

Raphanus Sativus - A Review of Its Traditional Uses, Phytochemistry, and Pharmacology

Saha¹,

Paul²,

Afroz³

et al. 2023

Asian J Pharm Clin Res

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Raphanus sativus (Radish) is a widely used vegetable belonging to the family Brassicaceae, generally grown as annual or biennial plants, with a taproot which is much enlarged when it is cultivated. In Yemenite folk medicines, R. sativus juice is used in eliminating kidney stones. Few people, specifically in the Middle East, prefer to drink its juice in pursuit of certain health benefits. In Unani, Greeko-Arab, and Indian folk medicine, It is used as a home remedy for the treatment of many diseases such as jaundice, gallstone, liver diseases, rectal disorder, indigestion, and other gastric pains. This article has reviewed the information available on R. sativus ethnopharmacology, geographical distribution, chemical composition, and pharmacological uses. The information on botanical description, distribution, traditional uses, chemical composition, bioactive components, and therapeutic investigations was gathered from a comprehensive literature search of electronic databases such as Science Direct, PubMed, Web of Science, Wiley, ACS, Springer, Google Scholar, and SCOPUS until 2020 for publications. An elaborative study has been done on botanical characterization, traditional uses, chemical composition, and various pharmacological or therapeutic uses. Mainly this plant is fully loaded with polyphenolic compounds which exert a promising antioxidant property. This plant possesses various therapeutic benefits such as anti-inflammatory, anti-microbial, anti-tumorogenesis, anti-cancer, anti-diabetic, and anti-nephrotoxicity activity. The comprehensive literature analysis shows that a wide range of populations has utilized various parts of R. sativus around the globe. The above information shows that the plant holds a variety of hidden and unknown potentials which can be studied extensively for its phytoconstituents and therapeutic outcomes. However, while searching through the literature available, it was observed that there is a lack of information on its phytochemical profiling and its corresponding pharmacological benefits. It is believed that this review will help lay the groundwork for encouraging pharmacological and pharmaceutical studies.

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Section: Anti-inflammatory Activitymentioning

confidence: 94%

Raphanus Sativus - A Review of Its Traditional Uses, Phytochemistry, and Pharmacology

Saha¹,

Paul²,

Afroz³

et al. 2023

Asian J Pharm Clin Res

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show abstract

“…Catechins found in AN also exhibit anti-hypertensive effects. Gilani et al (2006) found that catechins not only dilate blood vessels but also possess antiplatelet activity. In a study by Ghayur et al (2011) , catechins isolated from AN demonstrated a clear antiplatelet effect, with IC50 values of 3.630, 1.876, 2.551, 1.541, and 2.640 mg/mL for platelet aggregation induced by arachidonic acid, adenosine diphosphate, platelet-activating factor, epinephrine, and calcium ionophore, respectively.…”

Section: Polyphenolsmentioning

confidence: 99%

Comprehensive insights into areca nut: active components and omics technologies for bioactivity evaluation and quality control

Sun,

Feng,

Hou

et al. 2024

Front. Pharmacol.

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Areca nut (AN), the fruit or seed of Areca catechu Linn, has many uses, including chewing and medicinal purposes. It has sparked worries about health due to the presence of alkaloids. Chewing AN may have a variety of negative consequences; however, the medicinal use of AN has no notable adverse effects. To completely understand and effectively use AN, researchers have investigated its chemical makeup or biological activity, analyzed the variations between different AN species and different periods, and improved extraction and processing procedures. Today, an increasing number of researchers are exploring the underlying reasons for AN variations, as well as the molecular mechanisms of biosynthesis of chemical components, to comprehend and change AN at the genetic level. This review presents an overview of the clinical study, pharmacology, and detection of the main bioactive components in AN, and the main factors influencing their content, delving into the omics applications in AN research. On the basis of the discussions and summaries, this review identifies current research gaps and proposes future directions for investigation.

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Potential analgesic, anti-inflammatory and antioxidant activities of hydroalcoholic extract of Areca catechu L. nut

Bhandare

Kshirsagar

Vyawahare

et al. 2010

Food and Chemical Toxicology

116

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Studies on the Hypotensive, Cardio-suppressant, Vasodilator and Antiplatelet Activities of Betel Nut Crude Extract and its Constituents

Cited by 23 publications

References 23 publications

Raphanus Sativus - A Review of Its Traditional Uses, Phytochemistry, and Pharmacology

Raphanus Sativus - A Review of Its Traditional Uses, Phytochemistry, and Pharmacology

Comprehensive insights into areca nut: active components and omics technologies for bioactivity evaluation and quality control

Potential analgesic, anti-inflammatory and antioxidant activities of hydroalcoholic extract of Areca catechu L. nut

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