Studies on the immediate and delayed leucocytosis elicited by brief (30-min) strenuous exercise

McCarthy, D. A.; Macdonald, I. A.; Grant, Michael; Marbut, Mossa M.; Watling, Mil; Nicholson, S; Deeks, Jonathan J; Wade, A J; Perry, Janet

doi:10.1007/bf00843760

Cited by 56 publications

(40 citation statements)

References 11 publications

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“…Levels of neutrophils remained elevated at 1-h Post, and have consistently been shown to remain elevated for between 2 to 24 h thereafter in nondisabled individuals [37], with the magnitude thought to be dependent on the exercise intensity and/or duration [38]. These effects are likely a result of demargination of cells adhered to the endothelial cells of the vasculature through the release of catecholamines or through a delayed release of neutrophils from the bone marrow associated with a rise in circulating cortisol [39]. However, some aspects of the neutrophils' functional capacity may be compromised [3].…”

Section: Discussionmentioning

confidence: 98%

Immunoendocrine responses of male spinal cord injured athletes to 1-hour self-paced exercise: Pilot study

Allgrove

Chapman²,

Christides³

et al. 2012

JRRD

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Abstract-This study examined the effect of a 1 h, self-paced handcycling time trial on blood leukocytes, mucosal immunity, and markers of stress in paraplegic athletes. Nine male paraplegic athletes (spinal injury level thoracic 4-lumbar 2) performed 1 h of handcycling exercise on a standard 400 m athletics track. Heart rate (HR) was measured continuously during exercise, and a retrospective rating of perceived exertion (RPE) was obtained immediately after. Venous blood and saliva samples were collected immediately before exercise (Pre-Ex), after exercise (End-Ex), and 1 h postexercise (1-h Post). The athletes completed mean +/-standard error of mean 22.4 +/-1.1 km cycling at HR 165 +/-2 beats/min, RPE 15 +/-1, and blood lactate 7.9 +/-2.5 mmol/L. Total leukocytes increased 72% and neutrophils increased 74% End-Ex; both remained elevated at 1-h Post (both p < 0.05). Lymphocytes increased 53% and natural killer cells increased 175% End-Ex (both p < 0.05), but returned to near baseline levels 1-h Post. Increases (p < 0.05) were observed End-Ex in alpha-amylase activity (p < 0.05), which returned to baseline at 1-h Post, but there was no significant change in saliva flow rate, salivary immunoglobulin A, or cortisol. These data confirm that 1 h of handcycling exercise elevated circulating leukocytes but had a minimal effect on mucosal immunity. These changes appear to be associated with alpha-amylase rather than cortisol.

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Section: Discussionmentioning

confidence: 98%

Immunoendocrine responses of male spinal cord injured athletes to 1-hour self-paced exercise: Pilot study

Allgrove

Chapman²,

Christides³

et al. 2012

JRRD

View full text Add to dashboard Cite

show abstract

“…The numbers of granulocytes, lymphocytes and monocytes have been reported to be increased after exercise [1][2][3][4][5][6][7][8][9][10][11][12] , but the numbers of samples in these studies were too small to come up with a consensus. In addition, effects of exercise on gender differences are surprisingly unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Intensive short-term exercise resulted in increased leukocytosis which included lymphocytes, granulocytes and monocytes concomitant with alterations in plasma catecholamine levels [8] . A 30 min exercise in 8 male volunteers resulted in increased catecholamine and leukocytosis, whereas another round of exercise 3 h later also resulted in enhanced leukocytosis "neutrophils and lymphocytes" and increased cortisol levels [9] . It was proposed that catecholamine increases the number of circulating leukocytes, whereas cortisol which has a later effect maintains this increase in the vascular compartments [10] .…”

Section: Introductionmentioning

confidence: 95%

Effects of exercise on leukocytosis and blood hemostasis in 800 healthy young females and males

Sand

Flatebø

Andersen

et al. 2013

WJEM

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AIM:To investigate the effects of exercise on healthy individuals of both genders. METHODS:This study lasted 6 years and involved about 800 healthy people. Individuals were divided into females and males and further sub-divided into two groups; in the first group individuals run (or skied in the winter time) and then rested for 3 h, whereas individuals in the second group intensely cycled for 5 min. The status of health was determined by measuring the sedimentation rate and the intensity of exercises by measuring the heart rate. Blood samples were collected before and after exercise. RESULTS:We observed that in the first group a significant increase of the total white blood cells, segmented neutrophils, band neutrophils, eosinophils and to a lesser extent lymphocytes but not monocytes in the blood circulation. However, all cell types were increased in the circulation after 5 min intense exercise. No differences in the pattern of cell increase were observed among the genders. Activated partial thromboplastin time (APTT) and D-dimer were also measured in the blood of individuals who cycled intensely for 5 min to determine the coagulation and fibrinolytic activities in the blood. APTT is reduced and D-dimer values significantly increased after intense exercise. However, APTT was statistically lower in males than females, whereas no differences in the D-dimer values were observed among the genders. CONCLUSION:Our results indicate that exercise whether leisure or strenuous affects leukocytosis and hemostasis in both genders. A major advantage of this study is the high numbers of individuals involved and the inclusion of both females and males values.

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“…The hypoglycemic effect of L. album could be in part attributed to its polyphenol compounds (37). Our study had some limitations: 1) we didn't measure plasma catecholamines and cortisol, since these hormones could affect neutrophil distribution (38,39). 2) Using DHR dye, the degree of mitochondrial ROS might be affected by the unsolicited alterations in the mitochondrial membrane potential (34); therefore, an additional probe is needed to confirm the results (33).…”

Section: Discussionmentioning

confidence: 99%

Effect of Lamium Album on Mitochondrial Oxidative Stress in Diabetic Rats

et al. 2017

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Background: Diabetes mellitus (DM) is characterized by the presence of hyperglycemia. It has been documented that oxidative stress and reactive oxygen species (ROS) production have a key role in the pathogenesis of diabetes and its complications. Neutrophils as a part of immune system produce ROS, neutrophils function might be altered in diabetes. Lamium album is known to have antioxidant, and free radical scavenging actions. The aim of the present study was to evaluate the potential effect of L. album on mitochondrial ROS production from circulating neutrophils in diabetic rats. Materials and Methods: Twenty-one male Wistar rats were randomly divided into three groups: normal control rats receiving daily saline; diabetic control rats receiving daily saline; and diabetic rats treated daily with hydroalcoholic extract of L. album (100 mg/kg) for 28 days. On the 28 th day of treatment, whole blood samples were obtained and mitochondrial ROS of neutrophils were measured by dihydrorhodamine (DHR) flow cytometric method. Also, fasting blood sugar (FBS) was measured. Results: Mitochondrial ROS didn't show any significant differences among diabetic rats treated with L. album extract, diabetic control rats, and normal control rats (P=0.8). Serum glucose in diabetic control was significantly higher than normal control rats (P=0.0001). However, L. album caused a remarkable decrease in serum glucose of diabetic rats (P=0.03). Conclusion: According to the present findings, it seems that L. album at a dose of 100 mg/kg could not decrease mitochondrial ROS production from neutrophils in diabetic rats. Further studies considering higher concentrations of L. album are appreciated to evaluate its impact on the production of mitochondrial ROS along with extracellular ROS in diabetes condition.

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Studies on the immediate and delayed leucocytosis elicited by brief (30-min) strenuous exercise

Cited by 56 publications

References 11 publications

Immunoendocrine responses of male spinal cord injured athletes to 1-hour self-paced exercise: Pilot study

Immunoendocrine responses of male spinal cord injured athletes to 1-hour self-paced exercise: Pilot study

Effects of exercise on leukocytosis and blood hemostasis in 800 healthy young females and males

Effect of Lamium Album on Mitochondrial Oxidative Stress in Diabetic Rats

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