Studies on the immune response to Newcastle disease virus in poultry

Maraqa, Anwar

doi:10.31274/rtd-180813-10259

Cited by 2 publications

(3 citation statements)

References 107 publications

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“…Our results indicated a significantly higher cell-mediated immune response after vaccination with AG/VG vaccine, as estimated by a MTT assay using PHA and specific NDV antigen. Lymphocyte proliferation can occur as early as 2-3 days after a primary or secondary vaccination (Maraqa, 1996;Reynolds & Maraqa, 2000). There was a highly significant positive correlation between SI values of PHA and NDVr (P<0.01) e.g.…”

Section: Discussionmentioning

confidence: 97%

“…Vaccine failure in birds may be due to two main reasons including low vaccine efficacy and variation in response to vaccination (Kapczynski et al, 2013). Effective vaccination against Newcastle disease requires measurement of specific antibodies titres since a correlation exists between antibody response and transmission potential to susceptible birds (Maraqa, 1996). Titre of specific antibodies can then be used for determination of the critical vaccination coverage and herd immunity (Van Boven et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Turkey humoral and cell-mediated immune responses to a Newcastle viscerotropic vaccine and its association with major histocompatibility complex.

Al-Karagoly¹,

Nikbakht²,

Hassanzadeh³

et al. 2019

BJVM

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Al-Karagoly, H., G. Nikbakht, M. Hassanzadeh & T. Tolouei, 2019. Turkey humoral and cell-mediated immune responses to a Newcastle viscerotropic vaccine and its association with major histocompatibility complex. Bulg. J. Vet. Med., 22, No 1,[26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] Immune responses to vaccines are mainly influenced by the nature of vaccines and host variation in response to vaccination. In this study we aimed to investigate turkey humoral and cell-mediated immune responses to a Newcastle viscerotropic vaccine and its association with major histocompatibility complex (MHC). Turkeys were vaccinated with Villegas-Glisson/University of Georgia (VG/GA) attenuated vaccine against Newcastle disease. The stimulation index of lymphocyte proliferation and antigen-specific local secretory IgA responses in bile, duodenum, ileum, as well as serum IgY and IgA responses were analysed by enzyme-linked immunosorbent assay. The turkey MHC class II B locus was selected as candidate gene for detection of associations with cellular and humoral immune responses. Significant differences were observed between both cellular and humoral responses of vaccinated and unvaccinated groups. A significant positive correlation was also found between ND specific IgY and ND specific IgA titres in serum, intestine (duodenum and ileum) and trachea. Moreover, the correlation between specific IgA titres in ileum and specific bile, duodenum and trachea was positively significant. High resolution melting analysis (HRM) was used to genotype MHC class II B exon 2. Eight melting profiles (A-G) were identified, among which, profile G showed a significant association with cellular response. The profile B revealed significant association with total IgA titres in serum and ileum. These findings help our understanding of the association of turkey MHC types with immune responses. Further correlation analysis between serum and mucosal antibody titres demonstrated that the levels of IgY and IgA in serum can give an impression about the levels of secretory IgA and situation of mucosal immunity. Based on the significant effects, ND specific IgY in serum appears to be a promising indirect marker for specific IgA in serum and trachea.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Turkey humoral and cell-mediated immune responses to a Newcastle viscerotropic vaccine and its association with major histocompatibility complex.

Al-Karagoly¹,

Nikbakht²,

Hassanzadeh³

et al. 2019

BJVM

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show abstract

“…This may be an indication that the efficacy of vaccine reduces with time after vaccination and as such, routine vaccination should be encouraged among poultry breeders. Proliferation of lymphocyte can occur as early as 2-3 days after primary or secondary vaccination [26,27]. It is possible that vaccination of the turkeys had caused some elevation in the lymphocyte that resulted in the immediate significant increase in the antibody titre response at 3 days than 5 days of the post vaccination results.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the response of Turkey strains to Salmonella and Newcastle vaccines

Ikpeme

2021

ARRB

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This research work was carried out to evaluate the immune response of 3 turkey strains to salmonella and Newcastle vaccines measured via antibody titre. The study deployed a total of 120 poults (40 black, 40 white and 40 lavender) strains. To ascertain the initial antibody titre of all the birds, blood samples were obtained from their wing veins immediately after acclimatization for salmonella and Newcastle antibody titre. The test for salmonella and Newcastle antibody titre responses of the birds were performed using widal and haemagglutination inhibition (HI), respectively. The birds were divided into two broad groups tagged as A and B, which represented Salmonella and Newcastle vaccines, respectively. Each group had 3 sub-groups denoting the 3 strains of turkey used for the study. After vaccination, blood samples were collected from all the birds at 3 and 5 days for laboratory assessment of antibody titre response. The results showed that there was significant increase (p<0.05) in the antibody titre response of all the turkey strains after vaccination. Results obtained on the time of exposure of the birds to vaccine revealed that higher antibody titre values were obtained from the black and white turkey strains at 3 days than at 5 days after administration of Newcastle vaccine, except in the lavender strain, which had higher titre value at 5 days after Newcastle vaccination. Following administration of salmonella vaccine, black and lavender strains had statistically higher antibody titre response (2.03 and 2.10 mean loge widal, respectively) than white strain (1.86 mean loge widal). Similarly, the black strain also had higher antibody titre value when Newcastle vaccine was administered (2.35 mean loge HI) followed by lavender (1.99 mean loge HI) and white strain (1.71 mean loge HI). Black strains showed more antibody titre response and by implication, stronger immunity to Salmonella and Newcastle vaccines. More importantly, the differential response of the 3 turkey strains to vaccine could give turkey breeders the choice of selection of turkey breeds for disease resistance breeding.

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Studies on the immune response to Newcastle disease virus in poultry

Cited by 2 publications

References 107 publications

Turkey humoral and cell-mediated immune responses to a Newcastle viscerotropic vaccine and its association with major histocompatibility complex.

Turkey humoral and cell-mediated immune responses to a Newcastle viscerotropic vaccine and its association with major histocompatibility complex.

Evaluation of the response of Turkey strains to Salmonella and Newcastle vaccines

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