This study presents the effects of piston bowl size on the characteristics of a four-stroke single-cylinder diesel engine, which is considered in relation to changes in factors such as fuel injection pressure and turbocharger pressure. The study was carried out by 3D modeling using AVL Fire with an omega combustion chamber size and dimensions determined by the ratio between the diameter and depth of the piston bowl, which varies from 3.4 to 10.0. Additionally, the turbocharger pressure varies from 0.15 to 0.45 MPa at an engine speed of 1400 rpm and fuel injection pressure up to 300 MPa. The results show that the engine reaches the best values of indicated power, fuel efficiency, and a substantial decrease in emissions of nitrogen oxides at a turbocharger pressure from 0.25 to 0.35 MPa and with a ratio of the diameter to the depth from 7.8 to 10. However, the injection angle changes slightly, and the penetration depth and the tip velocity decrease with increasing boost pressure. While the piston bowl parameters only impact significantly on the tip velocity, the penetration and the spray angle are almost unchanged. In addition, the variation in the diameter of the combustion chamber has an influence on the fluctuation of the spray tip velocity and penetration.