Studies on the influence of biogenic amines and psychoactive drugs on the prognostic value of the TRH stimulation test in endogenous depression

Kirkegaard, C.; Bjørum, N.; Cohn, D.; Faber, Jens; Lauridsen, Ulrik Birk; Nerup, Jørn

doi:10.1016/0306-4530(77)90018-x

Cited by 93 publications

(12 citation statements)

References 10 publications

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“…This 'in-depth' study of severely depressed patients has failed to confirm the previously reported reduced TSH responsiveness to TRH, but in agreement with Loosen et al (1986) demonstrates the absence of any abnormal dopaminergic modulation of TSH release in depression. Since a number of investigations have found no or small effects of antidepressant drugs on the TSH response to TRH (Kirkegaard et al, 1977;Karlberg et al, 1978;Widerlov et al, 1978;Kjellman et al, 1985) the patients studied were allowed to continue their antidepressant medication, as deemed ethically desirable.…”

Section: Discussionmentioning

confidence: 99%

TSH responsiveness to TRH (‘the TRH test’)—of no diagnostic value in depression

Vaughan

O'Malley

Barker

et al. 1991

Human Psychopharmacology

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Serum free T4, free T3 and TSH (IRMA), along with TSH responsiveness to TRH (500 μg i.v.), were investigated in 12 patients, initially when severely depressed and again upon recovery, and in a group of age‐matched controls. The TSH response to TRH did not differ significantly between patients and controls, nor did it alter with treatment of depression. There were no significant differences in basal TSH levels. Free T3 levels were very significantly lower in untreated patients than in controls (p = 0·004), as were free T4 levels (p = 0·02), and had not improved significantly at recovery. Basal TSH levels showed a strong association with the integrated TSH response to TRH (p < 0·001) in both patients and controls. Thus in depression, as in thyoid dysfunction, the TRH test can be abandoned in favour of sensitive basal TSH measurement but, more importantly, the TRH test has no value in the diagnosis of endogenous depression or in monitoring treatment response. However, there is a reduction in free thyroid hormone levels in depression which has not been rectified by the time of clinical recovery.

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Section: Discussionmentioning

confidence: 99%

TSH responsiveness to TRH (‘the TRH test’)—of no diagnostic value in depression

Vaughan

O'Malley

Barker

et al. 1991

Human Psychopharmacology

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“…Quanto ao emprego dos antidepressivos tricíclicos (ADT) no tratamento da depressão maior (DM) e sua ação sobre a função tireoidiana, o efeito mais comumente encontrado tem sido a redução de T4T e/ou de tiroxina livre (T4L) (Whybrow et al, 1972;Kirkegaard et al, 1977;Bech et al, 1978;Langer et al, 1980;Unden et al, 1986;Baumgartner et al, 1988;Muller e Boning, 1988;Anton, 1989;Singer, 1990;Höflich et al, 1992;Brady et al, 1994;Duval et al, 1996;Rao et al, 1996;Gendall et al, 2003). Esta diminuição de T4 e T4L, apesar de significativa, permanece dentro dos limites da normalidade e ocorre na recuperação do quadro clínico.…”

Section: Efeito Dos Antidepressivos Isrs Atualização Introduçãounclassified

Efeito dos antidepressivos ISRS sobre os hormônios tireoidianos

Bahls

Carvalho

Boeving

2007

J. bras. psiquiatr.

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Palavras-chaveFunção tireoidiana, ISRS, transtornos depressivos. RESUMOO objetivo deste artigo é realizar uma atualização sobre a ação de antidepressivos, com destaque aos inibidores seletivos de recaptação de serotonina (ISRS) na função tireoidiana de pacientes com depressão. Sete ensaios clínicos investigaram o efeito dos ISRS sobre a função tireoidiana. Apesar das diferenças metodológicas, o principal achado foi a tendên-cia à diminuição dos níveis plasmáticos de tiroxina, não necessariamente relacionada com a resposta clínica, e sem efeito sobre a tireotropina na maioria das pesquisas. Os estudos sugerem que os ISRS promovem efeitos na função tireoidiana em alguns pacientes com depressão, especificamente diminuição nos níveis plasmáticos de tiroxina. Porém, observou-se que a relação entre o uso de antidepressivos ISRS e a função tireoidiana não está suficientemente esclarecida. Mesmo nos casos de alteração nos níveis plasmáticos dos hormônios tireoidianos em resposta a ação dos ISRS, esta pode ser uma ação não específica sobre a função tireoidiana. ABSTRACT

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“…The general retardation of the hypothyroid individual makes such reports attractive, but they require confirmation from other clinics. The increase in serum thyrotropin (TSH) in response to the administration of its releaser TRH (TSH-releasing hormone, protirelin, pyroglutamyl-histidyl-prolinamide) appears to be subnormal in depressives (41,42,49,69). Gold et al (37) state that the TSH response is greater in the bipolar depressed patient than in the manic.…”

Section: Introductionmentioning

confidence: 99%

Biochemistry of Mental Depression

Sourkes

1977

Canadian Psychiatric Association Journal

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Studies on the influence of biogenic amines and psychoactive drugs on the prognostic value of the TRH stimulation test in endogenous depression

Cited by 93 publications

References 10 publications

TSH responsiveness to TRH (‘the TRH test’)—of no diagnostic value in depression

TSH responsiveness to TRH (‘the TRH test’)—of no diagnostic value in depression

Efeito dos antidepressivos ISRS sobre os hormônios tireoidianos

Biochemistry of Mental Depression

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