Studies on the inhibition of tumor cell growth and microtubule assembly by 3-hydroxy-4-[(E)-(2-furyl)methylidene]methyl-3-cyclopentene-1,2-dione, an intensively coloured Maillard reaction product

Marko, Doris; Kemény, Monika; Bernady, E; Habermeyer, Michael; Weyand, U; Meiers, S; Frank, Oliver; Hofmann, Thomas

doi:10.1016/s0278-6915(01)00093-x

Cited by 28 publications

(34 citation statements)

References 31 publications

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“…Pronyl-lysine was found to potentially inhibit the growth of human tumor cells in vitro by effectively shutting down the activity of the MAP kinase cascade [6]. Our date indicating the treatment of rats with pronyl-lysine on entire period and post-initiation regimens showed a marked reduction the number of AgNORs/ nucleus, which suggests that the mechanism of reduction may be due to decreased cell proliferation.…”

Section: Discussionmentioning

confidence: 63%

“…ACF was counted using a light microscope (40×). The ACF were classified as small (1-3), medium (4)(5)(6) or large (>6) by the number of crypts per foci. The number of ACF and the number of aberrant crypts (AC) in all colons were recorded.…”

Section: Experimental Designmentioning

confidence: 99%

“…During baking of bread dough, a complex cascade of non-enzymatic reactions, the so-called Maillard reaction, takes place between reducing carbohydrates and proteins and is chiefly responsible for the development of the attractive aroma and the typical brown coloration of the bread crust. MRPs have been reported to possess a wide range of biological activities including antioxidant, chemopreventive and antimutagenic effects [6]. Very recently, application of an in vitro antioxidant assay to fractions isolated from bread crust revealed the highest antioxidant potential of the dark brown, ethanol soluble fraction of the crust [7].…”

Section: Introductionmentioning

confidence: 99%

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Aberrant crypt foci and AgNORs as putative biomarkers to evaluate the chemopreventive efficacy of pronyl-lysine in rat colon carcinogenesis

2008

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Chemoprevention opens new perspectives in the prevention of cancer and other degenerative diseases. Use of target-organ biological models at the histological and genetic levels can markedly facilitate the identification of potential chemopreventive agents. Our aim was to study the chemopreventive efficacy of pronyl-lysine, a key antioxidant present in bread crust by evaluating, the total number of aberrant crypt foci (ACF), their distributions, dysplastic ACF, colonic tumor incidence and the expression of cell proliferation biomarker such as the argyrophilic nucleolar organizing region-associated proteins (AgNORs) in 1,2-dimethylhydrazine (DMH) induced colon cancer in rats. Male Wistar rats were randomized into seven groups, group 1 were control rats, group 2 received pronyl-lysine (2 mg/kg body weight p.o. everyday), rats in groups 3-7 were administered DMH (20 mg/kg body weight) in the groin for 15 weeks. In addition, group 4 (pre-initiation), 5 (initiation), 6 (post-initiation), and 7 (entire period) received pronyl-lysine (2 mg/kg body weight p.o) everyday. At the end of 34 weeks, pronyl-lysine supplementation showed markedly reduced tumor incidence, ACF development and also lowered number of AgNORs. Overall, these findings confirm that pronyl-lysine has a positive beneficial effect against chemically induced colonic preneoplastic progression in rats.

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Section: Discussionmentioning

confidence: 63%

Section: Experimental Designmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Aberrant crypt foci and AgNORs as putative biomarkers to evaluate the chemopreventive efficacy of pronyl-lysine in rat colon carcinogenesis

2008

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“…in coffee beverages, are hypothesized to act as antioxidants [26] but also act in the activation of chemopreventive enzymes [160]. In addition, several Maillard compounds identified as constituents of melanoidins were found to inhibit tumour cell growth [161,162].…”

Section: Final Stage Mrpsmentioning

confidence: 99%

Analysis and biological properties of amino acid derivates formed by Maillard reaction in foods

Silván

Lagemaat

Olano

et al. 2006

Journal of Pharmaceutical and Biomedical Analysis

161

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“…Some Maillard reaction products (MRPs) are known to enhance the proliferation of human tumor cells, and there also exist some MRPs which bring about quite opposite effect (Marko et al, 2002;. As one of MRPs, the carcinogenicity of HMF has long caused a quite stir in the research fields.…”

Section: Carcinogenic or Anti-carcinogenic Actionmentioning

confidence: 99%

Hydroxymethyl furfural in chinese herbal medicines: Its formation, presence, metabolism, bioactivities and implications

Gao¹,

Wen²,

Chen³

2015

Afr. J. Trad. Compl. Alt. Med.

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Background: Chinese herbal medicines (CHMs) must be processed before being prescribed to patients. During the processing, some CHMs became brown and as such 5-hydroxymethyl furfural (HMF) generated. Increasing attention is being paid to the safety and effectiveness of HMF. Methods: This paper summarized previous and recent reports on HMF formation, its presence in CHMs, its metabolism and bioactivities, together with its implications for CHMs. Results: HMF had been detected in 41 CHMs, and increased by about 12~1200 times after heat processing in some CHMs. Current data showed that HMF has limited genotoxicity but various bioactivities, such as anti-oxidative, anti-apoptotic, anti-inflammatory, anti-hypoxic, anti-microbial, and inhibiting sickling of red blood cells. Conclusion: Accumulation of HMF during heat processing of CHMs indicates that Maillard reaction and caramelization occurred. The other products of the two browning reactions deserve more attention in the following investigations on heat processed CHM.

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Studies on the inhibition of tumor cell growth and microtubule assembly by 3-hydroxy-4-[(E)-(2-furyl)methylidene]methyl-3-cyclopentene-1,2-dione, an intensively coloured Maillard reaction product

Cited by 28 publications

References 31 publications

Aberrant crypt foci and AgNORs as putative biomarkers to evaluate the chemopreventive efficacy of pronyl-lysine in rat colon carcinogenesis

Aberrant crypt foci and AgNORs as putative biomarkers to evaluate the chemopreventive efficacy of pronyl-lysine in rat colon carcinogenesis

Analysis and biological properties of amino acid derivates formed by Maillard reaction in foods

Hydroxymethyl furfural in chinese herbal medicines: Its formation, presence, metabolism, bioactivities and implications

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