Studies on the Inhibition of Adrenaline-Induced Aggregation of Blood Platelets

Glusa, Erika; Markwardt, Fritz; Barthe, Wolfgang

doi:10.1159/000137310

Cited by 20 publications

(1 citation statement)

References 16 publications

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“…Other -adrenoceptor antagonists (prazosin, doxazosin, urapidil, labetalol) exert slight inhibitory effects on platelet responses to catecholamine at concentrations 100-fold greater than phentolamine [351][352][353].…”

Section: Pharmacological Effects On Platelet Response To Catecholaminesmentioning

confidence: 99%

Role of catecholamines in platelet function: pathophysiological and clinical significance

Anfossi

Trovati

1996

Eur J Clin Investigation

167

107

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Platelets are involved in the pathogenesis of vascular damage in both atherosclerosis and arterial hypertension. Their reactivity in vivo is influenced by different factors, including sympathoadrenal activation, plasma levels of atherogenic lipoproteins and haemorrheological changes. In the present review, we examine the modulation of platelet function by the sympathoadrenal system and concentrate on the role of circulating catecholamines in the control of platelet responses. Human platelets exhibit both adrenergic and dopaminergic receptors that are influenced by different catecholamines. alpha(2)-Adrenoceptors of alpha(2A) subtype prevail on platelet membrane; through their stimulation, catecholamines potentiate the effects of other agonists and, at higher concentrations, initiate platelet responses, including aggregation, secretion and arachidonate pathway activation. Physiological and pathological conditions causing sympathoadrenal activation in vivo, i.e. physical activity, mental stress, insulin-induced hypoglycaemia, acute coronary ischaemia and heart failure, modify the circulating platelet populations and modulate platelet reactivity through an increase in circulating catecholamines. A sympathoadrenal hyperactivation modifies the function of circulating platelets through direct catecholamine effects, catecholamine-induced changes of haemodynamic factors and lipid pattern and inhibition of the vascular eicosanoid synthesis. The catecholamine effects on platelet function can be involved in the interplay among stress, adrenomedullary system activation and cardiovascular diseases.

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Section: Pharmacological Effects On Platelet Response To Catecholaminesmentioning

confidence: 99%