Studies on the inhibitory effects of curcumin and eugenol on the formation of reactive oxygen species and the oxidation of ferrous iron

Reddy, Amala; Lokesh, Belur R.

doi:10.1007/bf00926033

Cited by 270 publications

(149 citation statements)

References 35 publications

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“…), 2,2 0 -azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS .+ ) and N,N-dimethyl-p-phenylenediamine dihydrochloride (DMPD .+ ) radical (Reddy & Lokesh 1994;Fujisawa et al 2004;Ak & Gulcin 2008;Trujillo et al 2013). The antioxidant capacity of curcumin is also related to the inhibition of lipid peroxidation and the induction of nuclear factor E2-related factor 2 (Nrf2) translocation to the nucleus.…”

Section: Curcuminmentioning

confidence: 99%

Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity

Eugenio‐Pérez

Oca-Solano

Pedraza‐Chaverrí

2016

Pharmaceutical Biology

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Context Acetaminophen (APAP), also known as paracetamol and N-acetyl p-aminophenol, is one of the most frequently used drugs for analgesic and antipyretic purposes on a worldwide basis. It is safe and effective at recommended doses but has the potential for causing hepatotoxicity and acute liver failure (ALF) with overdose. To solve this problem, different strategies have been developed, including the use of compounds isolated from food, which have been studied to characterize their efficacy as natural dietary antioxidants. Objective The objective of this study is to show the beneficial effects of a variety of natural compounds and their use against acetaminophen-induced hepatotoxicity. Methods PubMed database was reviewed to compile data about natural compounds with hepatoprotective effects against APAP toxicity. Results and conclusion As a result, the health-promoting properties of 13 different food-derived compounds with protective effect against APAP-induced hepatotoxicity were described as well as the mechanisms involved in hepatoprotection.ARTICLE HISTORY

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Section: Curcuminmentioning

confidence: 99%

Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity

Eugenio‐Pérez

Oca-Solano

Pedraza‐Chaverrí

2016

Pharmaceutical Biology

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“…9 Several studies have demonstrated the antioxidant capacity of the eugenol and related compounds (like isoeugenol) to inhibit the lipidic peroxidation induced by reactive oxygen species. 11,12 It also inhibits the superoxide radical formation in the xanthine-xanthine oxidase system. 13 E1 can inhibit the hydroxyl radical generation, and can prevent the Fe 2+ oxidation in the Fenton reaction that generates the radical.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant capacity of eugenol derivatives

Hidalgo¹,

Rosa²,

Carrasco³

et al. 2009

Quím. Nova

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Recebido em 3/7/08; aceito em 14/1/09; publicado na web em 28/7/09 Toxicity and antioxidant capacity of eugenol derivatives (E2 = 2-Methoxy-4-[1-propenylphenyl]acetate, E3 = 4-Allyl-2-methoxyphenylacetate, E4 = 4-Allyl-2-methoxy-4-nitrophenol, E5 = 5-Allyl-3-nitrobenzene-1,2-diol, E6 = 4-Allyl-2-methoxy-5-nitrophenyl acetate) were evaluated in order to determine the influence of the sustituents. E2-E6 were synthesized from eugenol (E1). E1 was extracted from cloves oil, and E2-E6 were obtained through acetylation and nitration reactions. Antioxidant capacity evaluated by DPPH (1, 1-Diphenyl-2-picrylhydrazil) and ORAC fluorescein demonstrated that E1 and E5 have a higher capacity and the minor toxicity evaluated by red blood cells haemolysis and the Artemia saline test. In accordance with our results, the compound's (E1-E5) use in the pharmaceutical, cosmetic and or food industries could be suggested.

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“…Previously, MMS has been observed as oxidative-stress inducer (Horvaathovaa et al 1998). Curcumin due to its free radical scavenging property, by acting as electron donor and inhibition of lipid peroxidation acts as an antioxidant (Reddy andLokesh 1994, Sreejayan andRao 1994). Oxidative stress is the cause of many diseases, while curcumin has the ability to cure many diseases like diabetes and cancer due to its antioxidant capacity (Sajithlal et al 1998, Majithi et al 2005, Saha et al 2010.…”

Section: Discussionmentioning

confidence: 99%

Effect of Curcumin On the Genotoxicity Induced By Alkylating Agents

Isitez¹,

Çiğerci²

2017

AKU-J. Sci. Eng.

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DNA damage due to genotoxic stress is an important type of stress which organisms are exposed during the their life. The direct-acting alkylating agent methyl methanesulfonate (MMS), is covalently linked to DNA and cause DNA damage, creating an indirect effect of the alkylating agent cyclophosphamide (CP) cause to DNA damage by changing the function of cellular proteins. In this study, the effects of curcumin on MMS and CP treated mice DNA damage, total antioxidant capacity, total oxidant capacity (oxidative stress index) and genotoxicity markers such as micronucleus index, cell growth arrest and induced DNA damage, which is Gadd45 and Gadd153 genes expression levels were investigated.Curcumin reduce DNA damage, the number of micronucleus and oxidative stres occurred by both MMS and CP induction. Curcumin's protective effect on DNA damage was provided by inducing Gadd45 and Gadd153 mRNA expression levels. We could state that curcumin, a phenolic compound show protective effects before the damage. In brief, curcumin has both antioxidant and antigenotoxic effects. Alkilleyici Ajanlar Tarafından Uyarılan Genotoksisite Üzerine Curcumin'in Etkisi Anahtar kelimelerCurcumin, Alkilleyici ajanlar, Genotoksisite, Comet assay, Gen ekspresyonu. ÖzetDNA hasarı organizmaların yaşamı boyunca maruz kaldığı önemli bir genotoksik stres türüdür. Doğrudan etkili alkilleyici ajanlardan olan metil metansülfonat (MMS), DNA'ya kovalent olarak bağlanarak DNA'da hasar oluştururken, dolaylı yoldan etkili alkilleyici ajanlardan olan siklofosfamid (SP) ise hücresel proteinlerin fonksiyonlarını değiştirerek DNA hasarına sebep olur. Bu araştırmada, deneysel olarak MMS ve SP uygulanan farelerde DNA hasarı, total antioksidan kapasite, total oksidan kapasite (oksidatif stres indeksi) ile genotoksisite belirteci mikronukleus indeksi ve hücre büyümesini durduran ve indüklenmiş DNA hasarının belirteci olan genlerden Gadd45 ve Gadd153'ün ifadelerindeki değişiklikler ile bunlara curcumin'in etkileri araştırıldı. Önce curcumin, sonra MMS ve SP'in uygulandığı gruplarda, curcumin'in DNA hasar derecesini mononükleer lökositlerde azalttığı, kemik iliğinde oluşan mikronukleus sayısını azalttığı, plazmada oksidatif stresi azalttığı ve indüklenmiş DNA hasarının belirteci olan Gadd45 ve Gadd153'ün mRNA ekspresyon düzeylerinin uyarılmasını sağlayarak koruyucu özellik gösterdiği bulundu. Sonuç olarak, fenolik bir bileşik olan curcumin'in, hasar oluştuktan sonra değil de, hasar oluşmadan önce koruyucu özellik göstererek antioksidan ve antigenotoksik özelliğe sahip olduğu bulundu.

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Studies on the inhibitory effects of curcumin and eugenol on the formation of reactive oxygen species and the oxidation of ferrous iron

Cited by 270 publications

References 35 publications

Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity

Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity

Antioxidant capacity of eugenol derivatives

Effect of Curcumin On the Genotoxicity Induced By Alkylating Agents

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