Studies on the &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt; Chemotherapeutic Properties of the Antibiotic Myxin

Grünberg, E.; Berger, Josef; Beskid, G.; Cleeland, Roy; Prince, Herbert N.; Titsworth, E.

doi:10.1159/000220509

Cited by 19 publications

(10 citation statements)

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“…Its spectrum of activity is different, with marked activity against some Enterobacteriaceae but little activity against gram-positive organisms (6) Because mecillinam has a unique mechanism of action among /. ?-lactam antibiotics against bacterial cells, it was postulated and subsequently shown, both in vitro (15) and in animal models (5), that it may act synergistically with those drugs. This paper reports on the in vitro activity of mecillinam alone and in combination with a penicillin (ticarcillin), a cephalosporin (cefamandole), and a cephamycin (cefoxitin) against a variety of clinical isolates.…”

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confidence: 99%

Activity of mecillinam alone and in combination with other beta-lactam antibiotics

Fass¹

1980

Antimicrob Agents Chemother

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The in vitro activities of mecillinam, ticarcillin, cefamandole, and cefoxitin, singly and in all possible combinations, against 53 clinical isolates were studied by a checkerboard method of determining miniimal inhibitory concentrations. For selected representative strains, bactericidal activity was determined by minimal bactericidal concentrations and killing curves. Mecillinam was the least active antibiotic against gram-positive cocci, Pseudomonas aeruginosa, and Bacteroides fragilis and the most active against Enterobacteriaceae. Reproducibility of mecillinam minimal inhibitory concentrations for susceptible Enterobacteriaceae was often poor, however, due to minor variations in inoculum size. When mecillinam resistance was observed with Enterobacteriaceae, partial inhibition could be demonstrated at concentrations below miimal inhibitory concentrations, and bacterial cells were consistently ovoid or round; under those conditions the addition of a second study antibiotic resulted in marked synergistic inhibition and killing which was independent of inoculum size and susceptibility to the second antibiotic. In contrast, synergy with mecillinam against mecillinam-susceptible strains or with other antibiotic combinations against any species was not consistently observed.Mecillinam (formerly called FL 1060) is the prototype of a relatively new class of fi-lactaxr antibiotics. Unlike the penicillins, cephalosporins, and cephamycins, it has a 6-amidino rathei than a 6-acylamino side chain.

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confidence: 99%

Activity of mecillinam alone and in combination with other beta-lactam antibiotics

Fass¹

1980

Antimicrob Agents Chemother

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“…Oral tolerance was determined with the ma terial suspended in water and administered by intubation tube and syringe. After an observation period of up to 10 days, the LD90 _ I00 was determined and the LD50 was calculated by the probit method [12].…”

Section: Toxicological Studiesmentioning

confidence: 99%

Orally-Administered Silver Sulfadiazine: Chemotherapy and Toxicology in CF-1 Mice; Plasmodium berghei (Malaria) and Pseudomonas aeruginosa

Wysor¹

1975

Chemotherapy

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Silver sulfadiazine when administered orally and subcutaneously to CF-1 mice in doses not exceeding 1,050 mg/kg proved to have minimal toxicity. No pathology or abnormal reactions were seen in CF-1 mice after receiving 1,050 mg/kg orally and subcutaneously once a day for 30 days. Silver sulfadiazine in doses of 1,050 mg/kg, once a day for 5 days cured mice of Plasmodium berghei even after splenectomy. Parasitemia was reduced to zero in 1–3 days and antimalarial activity was not inhibited significantly with doses of 313 mg/kg/day of PABA, thereby indicating that silver sulfadiazine’s antimalarial mode of action is different from that of the sulfonamides. Doses of 1,050 mg/kg/day had significant activity against systemic infections of Pseudomonas aeruginosa.

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“…amylolyticus, inhibits Hymenolepis nana when given orally at 25 mg/kg [297]. The broadspectrum antibiotic myxin also has slight activity against H. nana in mice [298]. Finally it has been demonstrated that treatment of very young H. diminuta worms (4 days after host infection) with 9.5-15.9 ,amol of actinomycin D results in a 100% inhibition of DNA-dependent RNA synthesis and a > 90% inhibition of the incorporation of uridine into RNA [299]: it was postulated that actinomycin D should be useful in studying gene activity during the development of H. diminuta.…”

Section: Antibioticsmentioning

confidence: 99%

Progress in the Experimental Chemotherapy of Helminth Infections; Part I, Trematode and Cestode Infections

Islip

1973

Progress in Drug Research / Fortschritte Der Arzneimittelforschung / Progrès Des Recherches Pharmaceutiques

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Studies on the <i>in vitro</i> and <i>in vivo</i> Chemotherapeutic Properties of the Antibiotic Myxin

Cited by 19 publications

References 0 publications

Activity of mecillinam alone and in combination with other beta-lactam antibiotics

Activity of mecillinam alone and in combination with other beta-lactam antibiotics

Orally-Administered Silver Sulfadiazine: Chemotherapy and Toxicology in CF-1 Mice; <i>Plasmodium berghe</i><i>i</i> (Malaria) and <i>Pseudomonas aeruginosa</i>

Progress in the Experimental Chemotherapy of Helminth Infections; Part I, Trematode and Cestode Infections

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