Studies on the Measurement of α-Methyldopa in Pregnant Women and the Newborn Infant

Setchell, K. D. R.; Lawson, AM; Jones, H E; Cummings, A. J.

doi:10.1007/978-1-4613-3991-5_5

Recent Developments in Mass Spectrometry in Biochemistry and Medicine 1978

DOI: 10.1007/978-1-4613-3991-5_5

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Studies on the Measurement of α-Methyldopa in Pregnant Women and the Newborn Infant

K. D. R. Setchell¹,

AM Lawson²,

H E Jones³

et al.

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1979

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A study of the disposition of alpha‐methyldopa in newborn infants following its administration to the mother for the treatment of hypertension during pregnancy.

Jones¹,

Cummings²,

Setchell³

et al. 1979

Brit J Clinical Pharma

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Harrow, Middlesex HAl 3UJ1 The nine infants participating in this study were born to mothers who received continuous therapy with a-methyldopa (0.75-2.0 g/day) for several weeks extending to the time of delivery. 2 The concentration of free and total (free plus conjugated) a-methyldopa was determined by gas chromatography-mass spectrometry in amniotic fluid, umbilical cord plasma and maternal plasma at delivery; also in urine collected over timed intervals from neonates during the first days after birth. 3 The results indicate that a-methyldopa administered to the mother is present in the infant at birth at a level comparable to the maternal level and persists for some days. The ratio of conjugated to free drug increases with time after birth. 4 The excretion of free and conjugated a-methyldopa in the urine indicated that the drug is slowly eliminated in the neonate by excretion in the urine and apparently by metabolism, mainly to the sulphate conjugate. 5 The concentration of free and conjugated a-methyldopa in amniotic fluid tended to be higher than in umbilical cord plasma but lower than in neonatal urine, conjugated drug predominated.

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A study of the disposition of alpha‐methyldopa in newborn infants following its administration to the mother for the treatment of hypertension during pregnancy.

Jones¹,

Cummings²,

Setchell³

et al. 1979

Brit J Clinical Pharma

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show abstract

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Studies on the Measurement of α-Methyldopa in Pregnant Women and the Newborn Infant

Cited by 1 publication

References 10 publications

A study of the disposition of alpha‐methyldopa in newborn infants following its administration to the mother for the treatment of hypertension during pregnancy.

A study of the disposition of alpha‐methyldopa in newborn infants following its administration to the mother for the treatment of hypertension during pregnancy.

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