Studies on the mechanism of action of thyroid-stimulating hormone

Field, James B.

doi:10.1016/0026-0495(68)90126-1

Cited by 27 publications

(3 citation statements)

References 74 publications

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“…6). That the reduction in TSH effect was not due to TSH adsorption by the latex microbeads was shown in experiments where TSH (100 mU/ml) and microbeads (25 ---------------------- Protein and RNA synthesis. During a 90 min incubation, microbead-induced phagocytosis in isolated thyroid cells was associated with a 10-30% increase in protein and RNA synthesis; although the increase appeared related to the quantity of xnicrobeads employed, no true "dose-response" relationship could be established (Table II).…”

Section: Introductionmentioning

confidence: 87%

“…The effects of microbead-induced phagocytosis on thyroid cell function, alone and in combination with TSH or DBcAMP, are summarized in Table IV. DISCUSSION Stimulation of endocytosis is a very early effect of TSH on thyroid (25). However, the relationship of the endocytotic process to the many other TSH effects on thyroid is not clearly defined.…”

Section: Introductionmentioning

confidence: 99%

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Stimulatory effects of induced phagocytosis on the function of isolated thyroid cells

Kowalski¹,

Babiarz²,

Sato³

et al. 1972

J. Clin. Invest.

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Section: Introductionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Stimulatory effects of induced phagocytosis on the function of isolated thyroid cells

Kowalski¹,

Babiarz²,

Sato³

et al. 1972

J. Clin. Invest.

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“…Tg-in-vitro-Test (Dextrangelfiltration) (°/oT3, Normalbereich: 3 2 -4 2 % ) (12,13). 6. Index des freien Schilddrüsenhormons (Index = °/oT3 X T4-J, Normalbereich: 1,33-2,50 |xg/ 100 ml) (12,13).…”

Section: Methodikunclassified

TSH-Stimulation der Schilddrüse Anstieg des Hormonspiegels und der Radiojodaufnahme

Heinze¹,

Rettig²,

Pfeifer³

et al. 1973

Nuklearmedizin

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ZusammenfassungBei 72 Patienten wurden TSH-Teste mit unterschiedlichen TSH-Dosen durchgeführt und der TSH-Effekt am Anstieg der 131J-Speicherung und des Schilddrüsenhormonspiegels (PB127J, %T3, T4-J, Index des freien Schilddrüsenhormons) gemessen. Die 131J-Speicherung stieg im Mittel um den Faktor 2 an und konnte durch höhere Dosen als 2 × 5 IE TSH nicht weiter gesteigert werden, während der Schilddrüsenhormonspiegel durch 3 × 10 IE TSH weiter erhöht werden konnte. In 50% stieg nach euthyreoter Ausgangslage der Index des freien Schilddrüsenhormons in den hyperthyreoten Bereich an, in 25% überstieg er 4,0 μg/ 100 ml, so daß der Test besonders bei autonomen Adenomen gefahrvoll sein kann (thyreotoxische Krisen).Beide Verfahren sind geeignet, die TSH-Stimulation der Schilddrüse zu erfassen. Ursachen für das Ausbleiben eines erwarteten TSH-Effektes werden diskutiert.

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The possible mediation by cyclic AMP of parathyroid hormone‐induced stimulation of mitotic activity and deoxyribonucleic acid synthesis in rat thymic lymphocytes

Whitfield

MacManus

Rixon

1970

Journal Cellular Physiology

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Purified parathyroid hormone (PTH) strongly stimulates the initiation of deoxyribonucleic acid (DNA) synthesis and thereby raises the flow of cells into mitosis in rat thymic lymphocyte populations maintained i n vitro. These actions of PTH are potentiated by caffeine and inhibited by imidazole which indicates that the hormonal action is mediated by cyclic adenosine 3',5',-monophosphate (cyclic AMP). The feasibility of cyclic AMP being the mediator of PTH action is established by the observation that a low concentration ( 1 0 -7 M ) of dibutyryl cyclic AMP precisely mimics the stimulatory action of the hormone on DNA synthesis and cell proliferation.

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Studies on the mechanism of action of thyroid-stimulating hormone

Cited by 27 publications

References 74 publications

Stimulatory effects of induced phagocytosis on the function of isolated thyroid cells

Stimulatory effects of induced phagocytosis on the function of isolated thyroid cells

TSH-Stimulation der Schilddrüse Anstieg des Hormonspiegels und der Radiojodaufnahme

The possible mediation by cyclic AMP of parathyroid hormone‐induced stimulation of mitotic activity and deoxyribonucleic acid synthesis in rat thymic lymphocytes

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