Studies on the mechanism of inhibition of thyroid function by lithium

Bagchi, Nandalal; Brown, Thomas R.; Mack, Robert E.

doi:10.1016/0304-4165(78)90242-8

Cited by 54 publications

(30 citation statements)

References 13 publications

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“…Also, the improvement in thyroid functions seen after 12 months of lithium treatment in our patients contradicts to some extent the concept of autoimmune thyroiditis as the only mecha nism of lithium-induced hypothyroidism. Our results are compatible with evidence of a direct inhibitory action of lithium on the thyroid gland [Bhattacharya and Wolff, 1976;Bagchi et al, 1978]. Crowe et al [1973] suggested that lithium might induce two types of hypothyroidism, one with thyroiditis, one without.…”

Section: Discussionsupporting

confidence: 81%

Lithium Therapy and Thyroid Function Tests

et al. 1984

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Thyroid function tests including thyroxine (T₄), T₃ test, thyroid-stimulating hormone (TSH), free T4 index and antithyroid antibodies were studied in 51 patients before the start of long-term lithium therapy and after 4 and 12 months on lithium. After 4 months on lithium, changes occurred in all laboratory parameters – T4 and T3 test levels decreased and TSH increased. After 12 months T₄ and T₃ test increased to pretreatment levels and TSH remained higher than before the start of lithium. During 1 year of lithium treatment only 1 patient developed clinical signs of hypothyroidism and started levo-thyroxine substitution therapy.

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Section: Discussionsupporting

confidence: 81%

Lithium Therapy and Thyroid Function Tests

et al. 1984

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“…The pellet diet supplied by Hindustan Levers was ground to powder. Lithium carbonate was adminstered in the diet (1·1 g per kg of diet) so as to give fairly constant levels of lithium in the serum (Bagchi et al 1978). The diet given to control groups was not supplemented with lithium.…”

Section: Methodsmentioning

confidence: 99%

Effect of Short-term and Long-term Lithium Treatment on Uptake and Retention of 10dine-131 in Rat Thyroid

Dhawan¹,

Sharma²,

Sharma³

et al. 1988

Aust. Jnl. Of Bio. Sci.

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“…Lithium inhibits the formation and release of thyroid hormone [1][2][3][4], and has produced hypothyroidism. However, lithium-induced thyrotoxicosis may also occur [5][6][7].…”

mentioning

confidence: 99%

“…Lithium carbonate alters thyroid function and has been reported to induce hypothyroidism [1][2][3][4]. Somewhat surprisingly, thyrotoxicosis has also been attributed to lithium administration [5][6][7].…”

mentioning

confidence: 99%