Studies on the Mechanism of Fructose-Induced Hyperuricemia in Man

Ih, Fox; Wn, Kelley

doi:10.1007/978-1-4757-1433-3_11

Cited by 13 publications

(10 citation statements)

References 4 publications

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“…While the relative risk data suggest a substantial biologic link, the risk difference data suggest that their contribution to the risk of gout in the population is likely modest given the low incidence rate among women. Because the urate-raising effect of fructose is greatest in patients with gout and hyperuricemia,8-10, 28 our findings may be even more relevant in those patients.…”

Section: Discussionmentioning

confidence: 71%

Fructose-Rich Beverages and Risk of Gout in Women

Choi¹,

Willett²,

Curhan³

2010

JAMA

265

177

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Section: Discussionmentioning

confidence: 71%

Fructose-Rich Beverages and Risk of Gout in Women

Choi¹,

Willett²,

Curhan³

2010

JAMA

265

177

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“…28 Furthermore, the increased risk of gout per serving was comparable to individual alcoholic beverages (35% for sugar sweetened soft drink and 49% and 15% for beer and spirits 28 ). Because the urate raising effect of fructose is greatest in patients with gout or hyperuricaemia [16][17][18][19] our findings may be even more relevant in those patients.…”

Section: Discussionmentioning

confidence: 72%

“…35 Thus minutes after an infusion of fructose, plasma (and later urinary) uric acid concentrations are increased. 16 In conjunction with purine nucleotide depletion, rates of purine synthesis de novo are accelerated, thus potentiating uric acid production. 20 In contrast, glucose and other simple sugars do not have the same effect.…”

Section: Discussionmentioning

confidence: 99%

“…14 15 Although such soft drinks contain low levels of purine they contain large amounts of fructose, which is the only carbohydrate known to increase uric acid levels. 12 [16][17][18][19] In humans, acute oral or intravenous administration of fructose results in a rapid increase in serum levels of uric acid through accentuated degradation of purine nucleotides 16 and increased purine synthesis. 20 21 This urate raising effect was found to be exaggerated in people with hyperuricaemia 18 or a history of gout.…”

Section: Introductionmentioning

confidence: 99%

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Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study

Choi

Curhan

2008

BMJ

482

299

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Objective To examine the relation between intake of sugar sweetened soft drinks and fructose and the risk of incident gout in men. Design Prospective cohort over 12 years. Setting Health professionals follow-up study. Participants 46 393 men with no history of gout at baseline who provided information on intake of soft drinks and fructose through validated food frequency questionnaires. Main outcome measure Incident cases of gout meeting the American College of Rheumatology survey criteria for gout. Results During the 12 years of follow-up 755 confirmed incident cases of gout were reported. Increasing intake of sugar sweetened soft drinks was associated with an increasing risk of gout. Compared with consumption of less than one serving of sugar sweetened soft drinks a month the multivariate relative risk of gout for 5-6 servings a week was 1.29 (95% confidence interval 1.00 to 1.68), for one serving a day was 1.45 (1.02 to 2.08), and for two or more servings a day was 1.85 (1.08 to 3.16; P for trend=0.002). Diet soft drinks were not associated with risk of gout (P for trend=0.99). The multivariate relative risk of gout according to increasing fifths of fructose intake were 1.00, 1.29, 1.41, 1.84, and 2.02 (1.49 to 2.75; P for trend <0.001). Other major contributors to fructose intake such as total fruit juice or fructose rich fruits (apples and oranges) were also associated with a higher risk of gout (P values for trend <0.05). Conclusions Prospective data suggest that consumption of sugar sweetened soft drinks and fructose is strongly associated with an increased risk of gout in men. Furthermore, fructose rich fruits and fruit juices may also increase the risk. Diet soft drinks were not associated with the risk of gout.

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“…The latter findings may be because of increased calcium excretion promoted by sucrose, fructose, and caffeine consumption 15–17,30. In addition, as previously stated, fructose consumption is reported to increase oxalate and uric acid excretion as well as promote insulin resistance 18–21,31–33. The latter is associated with a reduction in urinary pH and increased risk of uric acid stone formation 34–36…”

Section: Discussionmentioning

confidence: 77%

Effect of Soda Consumption on Urinary Stone Risk Parameters

Passman

Holmes

Knight

et al. 2009

Journal of Endourology

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Background and Purpose Fluid consumption has been demonstrated to influence kidney stone formation. Studies have shown that consumption of cola may be a risk factor for stone disease, while fluids containing citric acid may attenuate stone activity. Diet was not always controlled in these investigations, however. We undertook a study to determine the impact of three different fluids on urinary stone risk factors. Subjects and Methods Six healthy nonstone-forming adults were placed on a standardized metabolic diet and consumed three different types of fluid during three 5-day periods. There was a 2-day washout between each sequence. The three fluids administered during these periods were Le Bleu® water, caffeine-free Diet Coke,® and Fresca® (citrate containing). These two soda preparations were chosen to prevent the known increase in calcium excretion promoted by carbohydrates and caffeine. Twenty-four hour urine specimens were collected on days 4 and 5 of each sequence. The following urinary parameters were measured: Volume, calcium, oxalate, creatinine, uric acid, citrate, sodium, magnesium, phosphorus, sulfate, urea nitrogen, pH, and supersaturation indices. A paired t test was used for statistical analysis. Results Urinary volumes were significantly higher and supersaturation of calcium oxalate significantly lower compared with a self-selected dietary regimen. A decrease in uric acid was also seen in the Fresca cohort. There were no statistically significant differences for any of the urinary parameters. Conclusion There is no increased risk or benefit to consuming Fresca or caffeine-free Diet Coke compared with Le Bleu bottled water with respect to stone formation.

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Studies on the Mechanism of Fructose-Induced Hyperuricemia in Man

Cited by 13 publications

References 4 publications

Fructose-Rich Beverages and Risk of Gout in Women

Fructose-Rich Beverages and Risk of Gout in Women

Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study

Effect of Soda Consumption on Urinary Stone Risk Parameters

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