Studies on the Mechanism of Action of Secretin on Gastric Secretion

Albo, Robert J.; Silen, William; Ruby, Leonard; Hein, Michael F.; Harper, Harold A.

doi:10.1016/s0016-5085(65)80068-3

Cited by 9 publications

(5 citation statements)

References 11 publications

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“…In search of the mechanism for hypersecretion of gastric acid after cholecystojejunostomy (Roux-en-Y), they pointed out that the loss of body weight was markedly greater in dogs with cholecystojejunostomy (Roux-en-Y) than in those with cholecystoduodenostomy, and suspected that the possible fat indigestion and insufficiency in emulsion of fat due to the lack of bile, particularly bile salts, eventually worked together to reduce the production of gastric inhibitory hormone in the duodenum or upper small intestine. Inducing biliary diversion by the external biliary fistula and internal biliary fistula (side-to-side cholecystoileostomy), Albo et al (1965) studied on gastric acid secretion and further, providing the reversible biliary fistula, investigated the influence of the stimulation with secretin upon gastric acid secretion under the presence or absence of bile flow into the duodenum. The results showed that the external or internal biliary fistula abolished the inhibitory effect of secretin upon food-induced secretion from the Heidenhain pouch, and that the instillation of bile into the duodenum alone or during the administration of secretin caused inhibition of food-induced secretion.…”

Section: Discussionmentioning

confidence: 99%

Influence of biliary diversion upon gastric acid secretion.

Sekine¹,

Tsukui²,

Kameyama³

et al. 1981

Tohoku J. Exp. Med.

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The influence of biliary diversion upon gastric acid secretion and the serum gastrin level was investigated in dogs with Heidenhain pouch. Biliary diversion was carried out by the following operative procedures: 1) External biliary fistula (3 dogs), ligation and division of the common bile duct and construction of an external biliary fistula by inserting a cannula into the gallbladder. 2) Roux-en-Y internal biliary fistula (6 dogs), ligation and division of the common bile duct and construction of an internal fistula (cholecystojejunostomy) by anastomosing the gallbladder to the jejunum 10 cm distal to the ligament of Treitz, with restoration of end-to-side jejunojejunostomy. In each dog, a test meal (Dog Food, 300 g) was administered, and the gastric acid secretion and serum gastrin level were examined. In the external biliary fistula, the gastric acid secretion showed no increase after the test meal, while in the Roux-en-Y internal fistula the secretion from the Heidenhain pouch showed a significant increase in 4 of 6 dogs, with an increase rate of 110-330%. In either the external biliary fistula or the Roux-en-Y internal fistula, the serum gastrin level showed no significant change. However, in the dogs with the Roux-en-Y internal fistula allotted for the observation periods of 4 to 5 months, the serum gastrin level at 3 hr after the test meal was significantly higher than that at fasting. Further, in pursuit of the reproducibility of gastric acid secretion with the Roux-en-Y internal biliary fistula in the course between the first and second Roux-en-Y internal fistulae, the gastric acid secretion markedly increased in the cases of the Roux-en-Y internal fistula, without definite changes in the level of serum gastrin. Acute gastric ulcer developed in 2 of 6 dogs with the Roux-en-Y internal biliary fistula, but no fat indigestion was caused. These results suggest that gastric hypersecretion induced by biliary diversion may prove the possibility of presence of gastric secretagogue, different from gastrin, released in the upper jejunum. biliary diversion; internal biliary fistula; gastric acid secretion; serum gastrin level Biliary-intestinal anastomoses are used for reconstruction of the biliary tract. It has been pointed out that the surgical procedure for reconstruction of the biliary tract, particularly choledochoj ej unostomy, is likely to give rise to peptic ulcer. Recently, McArthur and Longmire (1971) reported an increased incidence of peptic ulcer in a relatively large series of patients who had undergone choledochojejunostomy for benign biliary obstruction. However, the possible

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Section: Discussionmentioning

confidence: 99%

Influence of biliary diversion upon gastric acid secretion.

Sekine¹,

Tsukui²,

Kameyama³

et al. 1981

Tohoku J. Exp. Med.

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“…A recent review of the world literature (Albo, de Lorimier, and Silen, 1963) lists 43 recorded cases and adds I other.…”

Section: Royal Victoria Infirmary Newcastle Upon Tynementioning

confidence: 99%

“…A recent review of the world literature (Albo, de Lorimier, and Silen, 1963) lists 43 recorded cases and adds I other.Further cases have been described (Olsen and Foley, 1961 ; Shaldon, 1961 ; Foex, 1962). Aetiological factors reported have included aerophagy, excessive intake of sodium bicarbonate, and external trauma.…”

mentioning

confidence: 99%

Spontaneous rupture of the stomach. A rare complication of pyloric stenosis

Fleming

Horton

Wagget

1966

Journal of British Surgery

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ROYAL VICTORIA INFIRMARY, NEWCASTLE UPON TYNESPONTANEOUS rupture of the stomach is a rare and usually fatal acute abdominal emergency. A recent review of the world literature (Albo, de Lorimier, and Silen, 1963) lists 43 recorded cases and adds I other.Further cases have been described (Olsen and Foley, 1961 ; Shaldon, 1961 ; Foex, 1962). Aetiological factors reported have included aerophagy, excessive intake of sodium bicarbonate, and external trauma.Pyloric stenosis has been present as a predisposing factor i n few of the recorded cases. CASE REPORTMrs. A., aged 45 years, was admitted to the Royal Victoria Infirmary as an emergency at 2.45 a.m. on 6 Nov., 1964, complaining of severe abdominal pain and distension. Her distress was such that she could not give an adequate history of her condition.HISTORY.-The history, obtained in retrospect, was that for 5 years she had suffered episodic epigastric pain, heartburn, and nausea. The pain had been relieved by alkalis. A barium-meal examination in 1961 was normal but a chest radiograph taken at the same time showed partial collapse of the lower lobe of the left lung. This was proved to be associated with bronchiectasis and treatment was given with good effect. She had suffered almost continuous epigastric discomfort and pain for 6 weeks before her admission to hospital and had been vomiting copiously. This pain had not been relieved by alkalis. The vomiting was of the type associated with pyloric stenosis. For 5 days she had eaten only small amounts of invalid and strained baby foods. In the 24 hours immediately preceding admission, she had vomited once, bringing up only a small volume of brown fluid. At 9.0 p.m. on 5 Nov., while sitting in a chair watching television, she developed a severe upper abdominal pain which persisted without relief for 5 hoyrs. At 2.0 a.m. on 6 Nov. it suddenly became 'agonizing .O N EXAMINATION.-The patient was obviously in great pain. She was thin, dehydrated, and appeared to have recently lost weight. Her respiration was rapid and grunting. The abdomen was distended and tympanitic with generalized tenderness and rigidity.Clinical findings were : temperature, 99" F. ; pulse, 130 per min.; blood-pressure, 1zo/80 mm. Hg. The blood picture was: Haemoglobin IOO per cent, P.C.V. 49 per cent, W.B.C. 8200 per c.mm. The blood chemistry gave: urea 54 mg. per IOO ml.; sodium 139 mEq./l.; potassium 3.8; chloride gg mEq./l.; carbon-dioxide content 28 mEq. per IOO ml. Radiographs of the'abdomen (supine and lateral decubitus) showed that: There is considerable gaseous distension of the bowel with hepato-diaphragmatic interposition of the colon. Some intraperitoneal fluid is present and there is the suggestion of free,intraperitoneal gas shown on the lateral decubitus film.A nasogastric tube was passed but no aspirate was obtained. Anintravenous infusionof normal saline was started.Her condition deteriorated at an alarming rate. The abdominal distension increased visibly and the respiratory capacity was correspondingly reduced. Breathing was rapid and ...

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“…Ή θεωρία αυτή έρχεται είς πλήρη αντίθεσιν με τάς μελετάς τοΰ Albo καί συν. (1965), από τους οποίους υποστηρίζεται δτι ή ανασταλ τική έπίδρασις τής σεκρετίνης έπί τής γαστρικής εκκρίσεως, απαιτεί τήν παρουσίαν χολής είς τήν άρχικήν μοϊραν τοΰ λεπτού εντέρου 3 .…”

Section: χολοπεπτικαι αναστομωσε ιςunclassified

“…'Αναφέρεται επίσης οτι παρουσία χολής είς το δωδεκαδάκτυλον είναι απαραίτητος δια να εκδήλωση ή σεκρετίνη τήν άνασταλτικήν της δρασιν επί τής γαστρικής εκκρίσεως 3 .…”

Section: συζητησιςunclassified

Μεταβολαι Της Γαστρικης Εκκρισεως Και Της Κυκλικης Μονοφωσφορικης Αδενοσινης (Camp) Του Γαστρικου Βλεννογονου Μετα Χοληδοχονηστιδοστομιαν: Πειραματικη Εργασια

Σιμοπουλοσ¹

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Έπεράτωσα τίς γυμνασιακές μου σπουδές εις το ΙΑ' Γυμν. 'Αρρένων 'Αθηνών το 1970. Κατόπιν εξετάσεων ένεγράφην το 1970 είς την Ίατρικήν Σχολήν τοϋ Πανεπ. 'Αθηνών. Έπεράτωσα τας πανεπιστημιακός μου σπουδάς τον Ίούνιον τοϋ 1976 με βαθμον «άριστα». Εις άπαντα τα ετη τώ'ν σπουδών μου είς την Ίατρικήν Σχολήν ελα-Θον υποτροφία έκ τοϋ Ι.Κ.Υ., λόγω επιδόσεως. 'Από τοϋ 1973 έως το τέλος των σπουδών μου είς την Ίατρικήν, ήμουν υπότροφος τοϋ Πανεπιστημίου 'Αθηνών («Κληροδότημα Παπαδάκη») κατόπιν εξετάσεων. Κατά το πρώτον τρΐμηνον τοϋ 1978 διετέλεσα υπότροφος τοϋ Έθνικοΰ Ιδρύματος Ερευνών, λαβών τον τίτλον τοϋ «βοηθού έρευνητοϋ». Άπο τοϋ 'Οκτωβρίου 1976 εως σήμερον, είδικεύμαι είς τήν Γενι κή ν Χειρουργική ν είς τήν Β' Χειρουργικήν Προπαιδευτικήν Κλινική ν τοϋ Πανεπιστημίου 'Αθηνών υπό τήν διεύθυνσιν τοϋ Καθηγητοϋ Γρηγ• Σκαλκέα. Γνωρίζω τήν 'Αγγλικήν γλώσσαν. Ή παρούσα διδακτορική διατριβή μοϋ ανετέθη ύπο τοϋ Καθηγητοϋ Γρ. Δ. Σκαλκέα διευθυντού της Β' Χειρουργικής Προπαιδευτικής Κλι νικής τοϋ Πανεπιστημίου 'Αθηνών. Συμμετεΐχον είς 14 επιστημονικός εργασίας αϊ οποϊαι άνεκοινώθησαν είς Ιατρικά Συνέδρια και έδημοσιεύθησαν είς Ιατρικά περιοδικά. 1.

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Studies on the Mechanism of Action of Secretin on Gastric Secretion

Cited by 9 publications

References 11 publications

Influence of biliary diversion upon gastric acid secretion.

Influence of biliary diversion upon gastric acid secretion.

Spontaneous rupture of the stomach. A rare complication of pyloric stenosis

Μεταβολαι Της Γαστρικης Εκκρισεως Και Της Κυκλικης Μονοφωσφορικης Αδενοσινης (Camp) Του Γαστρικου Βλεννογονου Μετα Χοληδοχονηστιδοστομιαν: Πειραματικη Εργασια

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