2024
DOI: 10.1007/s00210-024-03226-0
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Studies on the mechanisms of action of MR33317

Joachim Neumann,
C. Hesse,
S. Yahiaoui
et al.

Abstract: MR33317 was synthesized as an acetylcholinesterase-inhibitor and an agonist at brain 5-HT4-receptors. MR33317 might be used to treat Morbus Alzheimer. This therapeutic action of MR33317 might be based on MR33317´s dual synergistic activity. We tested the hypothesis that MR33317 also stimulates 5-HT4-receptors in the heart. MR33317 (starting at 10 nM) increased force of contraction and beating rate in isolated atrial preparations from mice with cardiac confined overexpression of the human 5-HT4-serotonin recept… Show more

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