Studies on the Metabolic Fate of Ultra Short Acting .BETA.1 Blocker ONO-1101. (1). Plasma Concentration-time Profile, Distribution and Excretion after Single Intravenous Administration to Rats.

Landiolol, an ultra short acting β1-blocker, improves pulmonary edema after cardiopulmonary resuscitation with epinephrine in rats

“…There have been no previous reports of the administration of landiolol in CPR. Tsunekawa et al [16] reported changes in plasma concentration after a bolus injection of landiolol in male Sprague-Dawley rats. According to their report, we assumed that the 0.5 mg/kg injection would reach the landiolol clinical concentration.…”