Studies on the metabolism of heparin

Über Verteilungsraum und Halbwertszeit von intravenös injiziertem Heparin

“…[4,6] sowie Blomback et al [1] fanden bei Mensch und Hund mit gerinnungsphysiologischer Methodik bzw. [4,6] sowie Blomback et al [1] fanden bei Mensch und Hund mit gerinnungsphysiologischer Methodik bzw.…”

Analytical Methods for Carbohydrates

“…The barium sulfate can be measured gravimetrically, 296 or spectrophotometrically with dilute barium chloride and potassium dichromate solution. 297 Where simple hydrolytic procedures cause appreciable interference through formation of humin, a reductive cleavage procedure has been employed. 297 Where simple hydrolytic procedures cause appreciable interference through formation of humin, a reductive cleavage procedure has been employed.…”

Preparation of potassium 2-deoxy-2-[35S]sulphoamino-d-glucose

“…Loomis, 1959Loomis, , 1961, the sequence of events involved in the disposal of the injected polymer is still not fully understood. Up to the present, studies on the metabolic fate of heparin have been based on observations made after the injection of unlabelled biosynthetic preparations of the polymer (Wilander & Holmgren, 1938;Wilander, 1939;Jacques, 1939;Reinert & Winterstein, 1939;Copley & Schendorf, 1941;Piper, 1947; Jaques, Napke & Levy, 1953), of preparations labelled biosynthetically with radioactive sulphate (Eiber, Danishefsky & Borelli, 1958;Danishefsky & Eiber, 1959;Loomis, 1961;Day, Green & Robinson, 1962) and of semi-chemically synthesized material prepared by the selective N-resulphation with trimethylamine-[35S]sulphur trioxide of N-desulphated commercial heparin (Levy & Petracek, 1962). The earlier reports dealt mainly with the urinary excretion of the apparently unchanged polymer, but in the later work attention has been given to the tissue distribution of radioactivity and to the appearance of inorganic [35S]sulphate, detectable in the tissues or in the urine, after the injection of the 35S-labelled materials.…”