Studies on the mode of action of the essential oil of LavenderLavandula angustifolia P. Miller)

Lis‐Balchin, Maria; Hart, Stephen L.

doi:10.1002/(sici)1099-1573(199909)13:6<540::aid-ptr523>3.0.co;2-i

Cited by 231 publications

(78 citation statements)

References 7 publications

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“…is a plant belonging to the Lamiaceae family. Essential oil obtained from the flowers of L. angustifolia is composed mainly of linalyl acetate, linalool, lavandulol, 1,8-cineole, lavandulyl acetate and camphor (Lis-Balchin and Hart 1999). Lavender is one of the most useful medicinal plants and has found wide application in perfumes and cosmetics.…”

Section: Lavandula Angustifolia Mill (Syn L Officinalismentioning

confidence: 99%

Influence of calcium content of tissue on hyperhydricity and shoot-tip necrosis of in vitro regenerated shoots of Lavandula angustifolia Mill.

Machado

Silva

Biasi

et al. 2014

Braz. arch. biol. technol.

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Section: Lavandula Angustifolia Mill (Syn L Officinalismentioning

confidence: 99%

Influence of calcium content of tissue on hyperhydricity and shoot-tip necrosis of in vitro regenerated shoots of Lavandula angustifolia Mill.

Machado

Silva

Biasi

et al. 2014

Braz. arch. biol. technol.

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“…Fresh flower tops of lavender are used for extract preparation [27,28]. The main compositions of lavender are linalool and linalyle acetate [29,30]. Additionally, lavender extracts inhibits glutamate-induced neurotoxicity and promotes anti-AchE activity enhancing the level of Ach in brain [31,32].…”

Section: Introductionmentioning

confidence: 99%

Clearance of Amyloid Beta Plaques from Brain of Alzheimeric Rats by Lavandula angustifolia

Soheili¹,

Tavirani²,

Saifeddine³

2012

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An important marker in neurodegenerative Alzheimer's disease (AD) is abnormal production of amyloid beta (Aβ) peptide leading to formation of plaques in the brain. Through decreasing Aβ aggregates, anti-inflammatory agents, phagocytosis, and proteolytic enzymes are known to decline risk of Aβ plaque formation. In the previous study we showed that aqueous extract of Lavandula angustifolia (lavender), with known anti-inflammatory effects, improves memory deficits in animal model of Alzheimer. Here, we assess if lavender play a role in clearance of Aβ plaques in the hippocampus. The Alzheimeric animals were created with intracerebroventricular injection of Aβ 1-42. To confirm formation of Aβ plaques, brain sections were stained by Congo red method. Twenty days post-injection they were administered with different doses (50, 100 and 200 mg/kg) of the aqueous extract of lavender for duration of 20 days. Our results demonstrated that 50 mg/kg of lavender not effectively influenced the Aβ plaques. On the other hand, the herbal medicine at the doses of 100 and 200 mg/kg markedly decreased the extent of Aβ aggregates. We concluded that the lavender extract dose dependently underlies elimination of Aβ plaques. The exact mechanism by which the herbal medicine removes the Aβ aggregates needs to be elucidated.

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“…The use of essential oils in the flavour and fragrance industry is well known, and their fragrances have been used in aromatherapy to induce mental tranquility or relaxation and to aid sleep in humans (Lavabre, 2001). In addition, many of them are found to exhibit varied biological properties, such as spasmolytic (Lis-Balchin and Hart, 1999) and anticonvulsant (Almeida et al, 2003) activities. These effects are probably due to the structural diversity of the essential oil constituents.…”

Section: Introductionmentioning

confidence: 99%

Sedative Effect of Monoterpene Alcohols in Mice: A Preliminary Screening

Sousa

Raphael

Brocksom

et al. 2007

Zeitschrift Für Naturforschung C

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Many essential oils and monoterpenes are used therapeutically as relaxing drugs and tranquilizers. In this study, ten structurally related monoterpene alcohols, present in many essential oils, were evaluated in mice to investigate their pharmacological potential in the central nervous system. Isopulegol (1), neoisopulegol (2), (ð)-isopinocampheol (3), (Ð)-myrtenol (4), (Ð)-cis-myrtanol (5), (+)-p-menth-1-en-9-ol (6) and (ð)-neomenthol (8) exhibited a depressant effect in the pentobarbital-induced sleep test, indicating a sedative property. (Ð)-Menthol (7), (+)-dihydrocarveol (9), and (ð)-isoborneol (10) were ineffective in this test. The results show that these psychoactive monoterpenes have the profile of sedative drugs, and this pharmacological effect is influenced by the structural characteristics of the molecules.

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Studies on the mode of action of the essential oil of LavenderLavandula angustifolia P. Miller)

Cited by 231 publications

References 7 publications

Influence of calcium content of tissue on hyperhydricity and shoot-tip necrosis of in vitro regenerated shoots of Lavandula angustifolia Mill.

Influence of calcium content of tissue on hyperhydricity and shoot-tip necrosis of in vitro regenerated shoots of Lavandula angustifolia Mill.

Clearance of Amyloid Beta Plaques from Brain of Alzheimeric Rats by Lavandula angustifolia

Sedative Effect of Monoterpene Alcohols in Mice: A Preliminary Screening

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