Studies on the modulation of the sleep-wakefulness continuum in man by fluoxetine, a 5-HT uptake inhibitor

Nicholson, A. N.; Pascoe, Peta A.

doi:10.1016/0028-3908(88)90180-3

Cited by 71 publications

(25 citation statements)

References 23 publications

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“…Single doses of FLU (20 to 80 mg) also aff ect the sleep of nondepressed, healthy adults (Nicholson and Pascoe 1988;Nicholson et al 1989;von Bardeleben et al 1989;Saletu et a1. 1991).…”

Section: Discussionmentioning

confidence: 99%

“…fNeuropsychopharmacology 10: 85-91, 1994J sleep that is reflected in increases in sleep latency and percentage of non-REM stage 1 sleep and decreases in total sleep time, sleep efficiency, and percentage of non REM stages 3 and 4 sleep (Nicholson and Pascoe 1986;Pastel and Fernstrom 1987;Kerkhofs et al 1990;Keck et al 1991;Keck and McElroy 1992). The duration of REM sleep and REM latency, as well as REM density, may also be affected by FLU (Nicholson and Pascoe 1988;von Bardeleben et al 1989;Nicholson et al 1989; Bakalian and Fernstrom 1990;Hanzel et al 1991;Saletu et al 1991). These effects likely depend upon both the dose and duration of FLU treatment.…”

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confidence: 99%

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The Effects of Fluoxetine on the Polysomnogram of Depressed Outpatients: A Pilot Study

Hendrickse

Roffwarg

Grannemann

et al. 1994

Neuropsychopharmacol

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The effects of fluoxetine (FLU) and its active metabolite, norfluoxetine (NFLU), on the polysomnogram (PSG) of nine depressed outpatients (eight with major depression; one with bipolar II, depressed phase disorder) were investigated by contrasting PSG values prior to treatment and during administration of FLU. The PSG changes were correlated with daily dose, cumulative dosage, single serum concentrations, and the total area under the serum concentration curve (AUC) of both FLU and NFLU.KEY WORDS: Fluoxetine; Norfluoxetine; Polysomnography; Serotonin; Depression Fluoxetine (FLU)-a potent, specifIc, serotonin reup take inhibitor-is an effective treatment for major depression (for a review, see Depression Guideline Panel, 1993). Serotonin affects the regulation of the sleep-wake cycle. It plays a role in the induction and maintenance of sleep as well as the character of sleep stage macro architecture and rapid-eye-movement (REM) sleep expression Oouvet et al. 1989).Fluoxetine reportedly causes a shift toward lighter Fluoxetine clearly increased both stage 1 sleep time and rapid-eye-movement (REM) latency and decreased both percent REM and REM density. With a few exceptions, the cumulative dosage of FLU and the AUC of FLU and NFLU were better predictors of the changes in awake and movement time in the PSG than single-sample concentrations of FLU and NFLU taken at the time of PSG assessment. fNeuropsychopharmacology 10: 85-91, 1994J sleep that is reflected in increases in sleep latency and percentage of non-REM stage 1 sleep and decreases in total sleep time, sleep efficiency, and percentage of non REM stages 3 and 4 sleep (Nicholson and Pascoe 1986;Pastel and Fernstrom 1987;Kerkhofs et al. 1990;Keck et al. 1991;Keck and McElroy 1992). The duration of REM sleep and REM latency, as well as REM density, may also be affected by FLU (Nicholson and Pascoe 1988;von Bardeleben et al. 1989;Nicholson et al. 1989; Bakalian and Fernstrom 1990;Hanzel et al. 1991;Saletu et al. 1991). These effects likely depend upon both the dose and duration of FLU treatment.Changes in polysomnogram (PSG) measures as sociated with chronic FLU treatment in depressed sub jects have been incompletely studied (Schenck et al. 1992). Relationships among PSG measures and serum concentrations of FLU and its active metabolite norflu oxetine (NFLU) have not been previously reported in depressed patients. This pilot study evaluated the effect of FLU and NFLU on PSG measures in a group of medication-responsive depressed outpatients.

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“…Single doses of FLU (20 to 80 mg) also aff ect the sleep of nondepressed, healthy adults (Nicholson and Pascoe 1988;Nicholson et al 1989;von Bardeleben et al 1989;Saletu et a1. 1991).…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

The Effects of Fluoxetine on the Polysomnogram of Depressed Outpatients: A Pilot Study

Hendrickse

Roffwarg

Grannemann

et al. 1994

Neuropsychopharmacol

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“…Administration of a TFD reduces REM latency (RL) (elapsed time between sleep onset and the first REM period) and increases REM percentage in normal male volunteers. 9 Consistent with the serotonergic depletion hypothesis for depression, patients with moderate to severe depression often display short RL, increased REM percentage, and increased ocular activity during REM sleep (increased REM density [RD]) compared with normal controls. Furthermore, administration of SSRIs increases RL and reduces REM percentage in healthy controls 9 and in depressed patients.…”

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confidence: 90%

Rapid Tryptophan Depletion, Sleep Electroencephalogram, and Mood in Men With Remitted Depression on Serotonin Reuptake Inhibitors

Moore¹,

Gillin²,

Bhatti³

et al. 1998

Arch Gen Psychiatry

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Background:In previous studies, depletion of brain serotonin by administration of a tryptophan-free amino acid drink (TFD) (1) temporarily reversed the antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) in euthymic patients who had a history of major depression, and (2) enhanced rapid eye movement (REM) sleep in normal volunteers. In this study, we hypothesized that the TFD would not only increase depressive symptoms but also the propensity for REM sleep in euthymic patients treated with SSRIs.

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“…In normal controls , fluoxetine increases REM latency, decreases REM sleep, reduces total sleep time and efficiency, and increases wakefulness and Stage 1 sleep. However, it is generally devoid of any effect on slow wave sleep (von Bardeleben et al 1989;Saletu et al 1991;Hendrickse et al 1994;Nicholson and Pascoe 1988). In depressed patients , fluoxetine appears to prolong REM latency, reduce REM sleep, reduce REM density, and increase Stage 1 sleep (Hendrickse et al 1994).…”

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confidence: 99%

Effects of Fluoxetine on the Polysomnogram in Outpatients with Major Depression

Trivedi

1999

Neuropsychopharmacology

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Studies on the modulation of the sleep-wakefulness continuum in man by fluoxetine, a 5-HT uptake inhibitor

Cited by 71 publications

References 23 publications

The Effects of Fluoxetine on the Polysomnogram of Depressed Outpatients: A Pilot Study

The Effects of Fluoxetine on the Polysomnogram of Depressed Outpatients: A Pilot Study

Rapid Tryptophan Depletion, Sleep Electroencephalogram, and Mood in Men With Remitted Depression on Serotonin Reuptake Inhibitors

Effects of Fluoxetine on the Polysomnogram in Outpatients with Major Depression

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