Studies on the Natural History of Multiple Sclerosis

Nagler, Benedict; Beebe, Gilbert W.; Jf, Kurtzke; Kurland, Leonard T.; Auth, Thomas L.; Nefzger, M. Dean

doi:10.1111/j.1600-0404.1966.tb02012.x

Cited by 22 publications

(10 citation statements)

References 6 publications

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“…We judged 527 men to be cases of MS: 476 definite and 51 probable. There were also 146 we had classed as definitely 'not MS' (other specific diagnoses) [5] .…”

Section: Clinical Diagnostic Criteriamentioning

confidence: 99%

“…An opportunity to explore both the early clinical features of this disease and its definition was provided by a unique series of white men with final diagnoses of MS in US Army hospitals during World War II [5] . We had excluded the small numbers of blacks and women to avoid possible bias in our epidemiologic assessment of the series.…”

Section: Clinical Diagnostic Criteriamentioning

confidence: 99%

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Historical and Clinical Perspectives of the Expanded Disability Status Scale

Kurtzke¹

2008

Neuroepidemiology

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Background: The measurement of neurologic impairment in multiple sclerosis (MS) is of importance in treatment trials and course of illness. Methods: This review describes the rationale underlying the formation and use of a bifid rating system, the (Expanded) Disability Status Scale (DSS) and the Functional Systems (FS). Results: All signs found at neurologic examination in MS can be consolidated into 8 mutually exclusive FS: pyramidal, cerebellar, brain stem, sensory, bowel and bladder, visual, cerebral and other, each of which, save ‘other’, is given ordinal grades from 0 to 5 or 6. Each FS correlates with the DSS, a step scale from 0 (normal) to 10 (death due to MS), which is an overall measure of neurologic abnormality. Dividing steps 1–9 each into 2 gives the Expanded DSS. The FS and DSS were used in an Army series to describe neurologic status at first diagnosis and over the first 20 years of illness. DSS severity at 5 years after onset, but not earlier, was highly predictive of later severity. Conclusions: Combination of the (Expanded) DSS and FS has been used successfully to assess impairment for natural history and treatment studies in MS.

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“…We judged 527 men to be cases of MS: 476 definite and 51 probable. There were also 146 we had classed as definitely 'not MS' (other specific diagnoses) [5] .…”

Section: Clinical Diagnostic Criteriamentioning

confidence: 99%

Section: Clinical Diagnostic Criteriamentioning

confidence: 99%

Historical and Clinical Perspectives of the Expanded Disability Status Scale

Kurtzke¹

2008

Neuroepidemiology

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“…Each of the five neurologists then recorded his diagnoses from the files at two points in time: from information available to the Army neurologist at his diagnosis, and then separately from all information in the entire record. Diagnostic criteria were prespecified and published as part of our first paper (Nagler et al, 1966). They were essentially the same as the criteria later promulgated by the Schumacher Committee (Schumacher et al, 1965).…”

mentioning

confidence: 99%

On the origin of EDSS

Kurtzke

2015

Multiple Sclerosis and Related Disorders

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“…9 In the aftermath of the failed trial, the second major benefit-the first being the disability status scale-was found. During post-trial meetings of the VA study group, members realised that they had detailed medical records of 16 Kurtzke and colleagues spent years sifting through medical records and analysing data. They published eight major papers on MS, the so called "army series."…”

mentioning

confidence: 99%