Studies on the Pharmacology of Conopharyngine, an Indole Alkaloid of the Voacanga Series

Carroll, PR; Starmer, G. A.

doi:10.1111/j.1476-5381.1967.tb02123.x

Cited by 3 publications

(4 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tannic acid is an antioxidant, hepatoprotective, hypocholesteromic and hypoglycemic agent [34] Tannin is used in the treatment of inflamed or ulcerated tissues. Melanthera Biflora is rich in alkaloid, prominent which is morphine used as an analgesic, local anaesthetic and anti-leishmanial agent [35], this shows that, the leaves can be used in curbing pain related symptoms. Flavonoid are of a particular importance in the human diet as there are evidence that they act as antioxidants, antiviral and anti-inflammatory agent.…”

Section: Phytochemical Composition Of the Melanthera Biflora Leaves Amentioning

confidence: 99%

Proximate and Phytochemical Profile of Melanthera biflora Leaves

Kalu

Ikewuchi

Ayalogu

et al. 2019

IJBcRR

View full text Add to dashboard Cite

The proximate and phytochemical composition of Melanthera biflora was investigated, using standard methods. From the obtained results the leaves had high moisture contents (71.1± 0.2%) and crude fiber (3.91 ± 0.5) while containing moderate protein (7.0 ± 0.03%), while containing lipid (1.10 ± 4%), ash (2.8 ± 0.2%), total carbohydrate (6.09 ± 0.2%) and caloric value (62.26±0.14 kcal/100g). Eleven Phytochemical families were detected with tannin as the most abundant (27.82%) consisting 100% tannic acid. Thirteen alkaloids (13.65%) were detected consisting mainly of morphine (28.05%), methylmorphine (16.22%), dephnoline (12.02%) biflorin, (20.63%), aromoline (12.61%) homoaromaline (7.79%). Twenty-three flavonoid (5.71%) chief among which were quercetin (44.21%), kaemferol (28.94%), dandzein (7.20%), letuolin (10.17%), salvagenin (6.76%), sinensetin 8.20% were detected. The most prominent of the ten carotenoids (2.48%), is lutein (40.76%), followed by carotene (17.90%), malvidin 5.63%, zeaxanthin (16.5%), viola-xanthin (9.5%). Sixty one terpenoid including linalool (40.98%), germacrene (12.74%), Alpha-terpineal 6.40%, terpinen – 4-01 (5.62%), and Gamma terpine were found in the leaves Of the six phenolic acids (16.26%) the highest was ferulic acid (53.94%), followed closely by vanilic acid (45.8%). Seven phytosterol (2.25%), consisting of sitosterol (65.3%), savenasterol (14.19%) stigmasterol (12.70%), and others were detected. The leaves had very a low hydroxycinnamic acid content (8.93x10-4%) content, consisting of eight known compounds of which caffeic acid (71.93%) and p-coumaric acid (27.91%) were the most abundant. They also had very a low allicins (1.94x10-4%) content, consisting of daillylthiosulphunate (97.05%), and methyl thiosulphinate (2.6%) and allylthiosulphin and allylthiosulphinate (0.3%). The leaves had a very low content of glycosides consisting of eight known compounds of which quabain (78.54%) were detected and they include gitogenin (22.04%), diosgenin (20.02), neohegen (20.79%). Their rich contents of nutrients and many bioactive molecules suggest strong nutraceutical potential of these leaves, further suggesting their likely use as functional a food and therapeutic uses in the management and prevention of diseases.

show abstract

Section: Phytochemical Composition Of the Melanthera Biflora Leaves Amentioning

confidence: 99%

Proximate and Phytochemical Profile of Melanthera biflora Leaves

Kalu

Ikewuchi

Ayalogu

et al. 2019

IJBcRR

View full text Add to dashboard Cite

show abstract

“…Negative inotropic and chronotropic effects were observed on the isolated heart. However, on the anesthetized cat, hypotension and bradycardia were produced which were not abolished by atropinization or vagotomy (Carroll & Starmer, 1967).…”

Section: Introductionmentioning

confidence: 99%

“…The pharmacological actions of conopharyngine (84) which was isolated from Voacanga species were investigated and comparisons were drawn with the reported effects of closely related alkaloids (Carroll & Starmer, 1967) (Figure 8). Conopharyngine (84) possessed potent analgesic activity unaccompanied by a loss of coordination.…”

Section: Introductionmentioning

confidence: 99%

“…Phytochemical investigation of V. africana gave the related epoxide ring-opened alkaloids viz., conoflorinol A (80), conoflorinol B (81) (Kunesch et al, 1967a). Another two bisindole alkaloids viz., 20′-hydroxyvoacamidine (82) (Geigy, 1967) and voacamine N-oxide (83) (Carroll & Starmer, 1967) (Figure 7) and were isolated from V. africana.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation