Studies on the physiology of lactation. I. The relation of lactation to the ovarian and hypophyseal hormones

Nelson, Warren O.; Pfiffner, J. J.

doi:10.1002/ar.1090510105

Cited by 33 publications

(2 citation statements)

References 24 publications

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“…In spite of this Nelson and Pfiffner (1931 ) stated that estrogen and progestin act on the AP causing production of a mammary factor.…”

Section: The Influence Of Pituitary Tissue On the Mammary Glandmentioning

confidence: 99%

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The Mammogenic Hormones of the Anterior Pituitary. I: The Duct Growth Factor

Lewis¹,

Turner²

1941

JAMA

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“…In spite of this Nelson and Pfiffner (1931 ) stated that estrogen and progestin act on the AP causing production of a mammary factor.…”

Section: The Influence Of Pituitary Tissue On the Mammary Glandmentioning

confidence: 99%

“…AP extract was found to be negative on mammary hyperplasia in immature rabbits according to Nelson and Pfiffner (1931). They stated that the mammary gland must first be subjected to ovarian influence, especially progestin, before normal secretion will occur.…”

Section: The Influence Of Pituitary Tissue On the Mammary Glandmentioning

confidence: 99%

The Mammogenic Hormones of the Anterior Pituitary. I: The Duct Growth Factor

Lewis¹,

Turner²

1941

JAMA

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General Physiology of the Anterior Hypophysis

Smith¹

1935

JAMA

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X‐irradiation of the ovaries of guinea‐pigs and its effect on subsequent pregnancies

Genther

1934

Am. J. Anat.

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A previous publication (Genther, '31) dealt with the irradiation of the ovaries of guinea-pigs and its effect on the oestrous cycle. It was found, regardless of the nature of the 1 THE AMERICAN JOURNAL O F ANATOMY, VOL. 55, N O . 1 JULY, 1934 2 IDA T. GENTHER X-RAYED OVARIES AND SUBSEQUENT PREGNANCIES 3soon after irradiation, when the cycles were still apparently normal, and later when the cycles were very abnormal.IV. Irradiation of the ovaries of very young animals, from 1 week of age to sexual maturity, to observe the effects on the cycles and snbsequent pregnancies.The experiments extended over a Long period of time, so that both the early and late effects of the irradiation could be observed. MATERIALS AND METHODSThe majority of animals used were laboratory raised. Uniformity of behavior was shown in that sexual maturity was reached between the weights of 275 and 315 gm. Cycles were normal and regular with few exceptions. Many controls were kept under the same conditions as the irradiated ones.The irradiation was carried out at the Children's Hospital under the direction of Dr. William Doughty, roentgenologist ; the treatments were given by Mrs. Mary Ware and Miss Ida V. Holt, x-ray technicians. The following setup was used : Milliamps, 5 Peak kilovolts, 165 Distance, 50 em. Port, 19 em. Filters, 1 mm. A1 + 2 mm. Cu.A half hour exposure was equivalent to 360 r units, calculated on the basis of 12 r units per minute, which were accurately measured. The minimum sterilization dose consisted of six half hour exposures, or 2160 r units, given within a week, the Lighter treatment of four exposures, or 1440 r units, given on successive days.A specially constructed box permitted four or five animals to be treated a t one time. Since the irradiation was dorsal, the animals were allowed to sit in a natural position, being held in place by a wooden halter that fitted snugly over the body behind the fore legs. No anaesthetic was used, since they iisually rested quietly. The entire body was covered with lead plates, except for a small strip over the region of the ovaries. In almost all ovaries studied thus far, both of a pair had

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Studies on the physiology of lactation. I. The relation of lactation to the ovarian and hypophyseal hormones

Cited by 33 publications

References 24 publications

The Mammogenic Hormones of the Anterior Pituitary. I: The Duct Growth Factor

The Mammogenic Hormones of the Anterior Pituitary. I: The Duct Growth Factor

General Physiology of the Anterior Hypophysis

X‐irradiation of the ovaries of guinea‐pigs and its effect on subsequent pregnancies

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