Studies on the physiology of the parathyroids

Salvesen, Harald A.

doi:10.3181/00379727-20-101

Cited by 24 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Just as was noted in earlier reports (2,7,8), the animals in the present study appeared to separate postoperatively into two population groups which can be labeled symptomatic and asymptomatic. The separation was definable within the first postoperative month by means of the serum phosphorus concentration and, usually, by clinical signs.…”

Section: Discussionsupporting

confidence: 57%

“…3 Associate Biochemist, Radioisotope Laboratory, Cincinnati Veterans Administration Hospital, Cincinnati, Ohio. that they then pass into a state of latent tetany" with an abnormality evidenced by chronic hypocalcemia and by the animals' inability to tolerate a low calcium intake (2). He thought that the observed calcium deficiency was "due to increased excretion of calcium through the intestines" as the result of a "lowered (calcium) threshold," itself the result of unknown factors.…”

mentioning

confidence: 98%

“…1 Associate Professor of Medicine, Metabolism Laboratory, Cincinnati General Hospital, Cincinnati, Ohio. 2 Assistant Professor of Surgery, Department of Surgery, Cincinnati General Hospital, Cincinnati, Ohio. 3 Associate Biochemist, Radioisotope Laboratory, Cincinnati Veterans Administration Hospital, Cincinnati, Ohio.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Effect of Thyroparathyroidectomy on the Clinical Course and the Serum Calcium and Phosphorus Concentration in Dogs

Wulsin

1965

Endocrinology

View full text Add to dashboard Cite

The postoperative course of 27 thyroparathyroidectomized dogs is described with periods of observation up to 600 days. Evidence obtained at necropsy and/or reoperation supports the idea that most, if not all, of the animals had been rendered aparathyreotic. Clinically the animals appeared to separate into one group of 18 which demonstrated severe continuing tetany and another group of 9 which either never demonstrated frank tetany or else did so only transiently.When the results of the serum calcium and inorganic phosphorus analyses available for these animals were analyzed according to this grouping of symptomatic and asymptomatic dogs, statistically significant differences were found between the 2 groups. While the differences might be explained in several ways, some evidence is presented suggesting that differences in intestinal absorption of dietary calcium may be one factor. (Endocrinology 76: 9, 1965)

show abstract

Section: Discussionsupporting

confidence: 57%

mentioning

confidence: 98%

See 1 more Smart Citation

Effect of Thyroparathyroidectomy on the Clinical Course and the Serum Calcium and Phosphorus Concentration in Dogs

Wulsin

1965

Endocrinology

View full text Add to dashboard Cite

show abstract

“…There seems to be no doubt of the increased nitrogen excretion in parathyroid tetany but Greenwald (38) showed this did not appear until after convulsions had started. Salvesen (64) found normal nitrogen excretion in latent tetany. After parathyoid extract in dogs, Greenwald and Gross (40) discovered an increased nitrogen excretion.…”

Section: Nitrogen Creatine and Creatinine Metabolismmentioning

confidence: 99%

The Functional Pathology of Hyper-Parathyroidism

Bulger¹,

Dixon²,

Barr³

et al. 1930

J. Clin. Invest.

View full text Add to dashboard Cite

For many years a few physicians have conceived of a condition the direct opposite of parathyroid tetany. Lundborg (53) and later Chvostek (21) believed this was manifest in myasthenia gravis but clinical observations did not confirm their belief. It was not until the use of Colip's (23) active parathyroid extract in animals had indicated the symptoms of such a state that hyperparathyroidism was recognizable as a clinical syndrome. It is now known that it constitutes a picture of disease as clearly defined as hyperthyroidism and follows closely the abnormalities which may be produced by parathyroid extract in animals. The literature and clinical features have been discussed in another paper (2).Many facts concerning functional abnormalities in hyperparathyroidism have already been determined. Colip (23) has shown that the various well-known manifestations following removal of the parathyroid gland are reversed after the parenteral administration of parathyroid extract. No longer is the theory tenable that the fall in serum calcium after parathyroidectomy is but a secondary phenomenon. Active extracts will prevent it and by raising the serum calcium entirely relieve the symptoms. Extracts readily cause an increase in the serum calcium in normal animals. It seems obvious now that the parathyroid glands are concerned with the regulation of the calcium concentration in the blood. They appear as an essential component in one of those remarkable regulatory mechanisms characteristic of the higher animals. The constancy of the serunrcalcium even under many of the most abnormal conditions is worthy of special emphasis. Although an increase in serum phosphate is typical of parathyroid tetany a reduction has not commonly been found in experiments in which parathyroid intoxication was rapidly produced. Robinson, Huffman and Burt (62), however, report a reduction in the serum phosphate of calves receiving parathyroid extract. Greenwald and Gross 143 HYPERPARATHYROIDISM (39) and later other investigators have definitely shown that effective parenteral administration of parathyroid extract causes an increased excretion and especially an increased urinary excretion of both calcium and phosphorus, phenomena quite the reverse of those following parathyroidectomy. A change in the tone and irritability of muscles which might be considered the opposite of tetany is suggested in the hypotonia often noted in animals with hypercalcemia. Berman (9) using galvanic currents has demonstrated a definite decrease in the electrical response in the peroneal nerve of normal dogs after a moderate increase of serum calcium produced by parathormone. These The following study of the functional pathology of the disease was started in April 1928, and has been continued to the present time. It will indicate the abnormalities encountered and will emphasize factors to be considered in diagnosis and treatment. MIETHODS OF STUDYThe patients with hyperparathyroidism were studied in the Metabolism Division of Barnes Hospital. Their diets were prepared in ...

show abstract

“…When a cure of tetany results, as from cod liver oil or ultraviolet radiation, the blood calcium rises. Similar disturbance in calcium metabolism takes place in tetany parathyreopriva (3), either experimental or following accidental removal of the parathyroid glands during thyroid operations. In gastric (4), bicarbonate (5), or hyperpneic tetany (6), however, the blood calcium remains normal, while the bicarbonate of the blood is increased with a tendency toward an alkaline reaction.…”

mentioning

confidence: 93%

A Comparative Study of the Effects of Various Treatments on the Calcium and Phosphorus Metabolism in Tetany

Liu

1928

J. Clin. Invest.

View full text Add to dashboard Cite

Studies on the physiology of the parathyroids

Cited by 24 publications

References 0 publications

Effect of Thyroparathyroidectomy on the Clinical Course and the Serum Calcium and Phosphorus Concentration in Dogs

Effect of Thyroparathyroidectomy on the Clinical Course and the Serum Calcium and Phosphorus Concentration in Dogs

The Functional Pathology of Hyper-Parathyroidism

A Comparative Study of the Effects of Various Treatments on the Calcium and Phosphorus Metabolism in Tetany

Contact Info

Product

Resources

About