Studies on the Prevalence of Type C Virus Associated with Gibbon Hematopoietic Neoplasms

Neoplasms and Proliferative Disorders in Nonhuman Primates

“…This occurrence is well documented; hematopoeitic tumors in gibbons account for most of the reports of neoplasia in apes [24-26, 72, 105]. Several isolates of a type C retrovirus called gibbon ape leukemia virus (GaLV) have been obtained from these tumors [62][63][64]. There is also a report of a 13-year-old wild-caught female orangutan that developed subacute myelomonocytic leukemia.…”

Oncogenicity of gibbon type‐C myelogenous leukemia virus

“…This indicates that the gibbon may be unusually susceptible to GaLV-induced malignancy; this is supported by the high frequency of hematopoietic disease among captive gibbons (Kawakami et al, 1975). The high incidence of leukemia in this species may also be related to the fact that the disease can be induced in animals several months old at the time of virus infection.…”

“…Although several GaLVs have been isolated from gibbons with natural lymphocytic and CGL (Kawakami et al, 1975), this study was conducted with one isolate originally obtained from a gibbon with naturally occurring CGL. This virus apparently has a stable genome that can consistently induce the same disease on passage in unrelated gibbons.…”

Characterization of a Simian Foamy Virus Isolated from a Spontaneous Primate Lymphoma

“…There have been numerous studies of hematopoietic malignancies aris ing in non-human primates maintained in captivity [5,21,22,24,30,36], Although many of these tumors have occurred in animals experimentally exposed to either biologic or physical agents [5,21,22,24,36], spontaneous tumors of this kind have been reported [21,24], Few, however, have been the subject of intensive investigation. In those species in which lymphomas have been studied, both herpesvirus (Herpesvirus saimiri) in spontaneous lymphomas of owl monkeys [16,29] and oncornaviruses in gibbons and baboons [10,21,22,36] have been associated with the development of these tumors.…”

“…In those species in which lymphomas have been studied, both herpesvirus (Herpesvirus saimiri) in spontaneous lymphomas of owl monkeys [16,29] and oncornaviruses in gibbons and baboons [10,21,22,36] have been associated with the development of these tumors. In addition, simian foamy viruses (SFV) have been isolated from similar malignancies arising in rhesus monkeys (Macaca mulatta) and baboons [28,30].…”