Studies on the promoting effects of medium chain fatty acid salts on the nasal absorption of insulin in rats.

Mishima, Misako; Wakita, Yasuyo; Nakano, Masahiro

doi:10.1248/bpb1978.10.624

Cited by 54 publications

(14 citation statements)

References 19 publications

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“…In comparison, other two enhancers, namely, sodium caprylate and bacitracin, increase the absorption of FITC-TP 5 to some extents as well. Previous studies demonstrated that the absorption promoting effect of sodium caprylate on insulin was in part associated with the chelating ability for calcium ions and the inhibitory action on leucine aminopeptidase activity [24]. In the present study, the immunomodulating activity of FITC labeled TP 5 was remained as the same as that of TP 5 (data from Chinese Peptide Company).…”

Section: Discussionsupporting

confidence: 60%

Pharmacokinetics, toxicity of nasal cilia and immunomodulating effects in Sprague–Dawley rats following intranasal delivery of thymopentin with or without absorption enhancers

et al. 2006

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Thymopentin (TP 5), a synthetic pentapeptide, has been used in clinic as a modulator for immnuodeficiencies through intramuscular administration. The objectives of this study was to investigate the pharmacokinetics using normal rats and toxicity of nasal cilia as well as immunomodulating effects using immunosuppression rats after intranasal delivery of thymopentin with or without an absorption enhancer. The absorption extent of fluorescein isothiocyanate (FITC) labeled TP 5 via nasal delivery at a single dose is significantly improved by incorporating sodium deoxycholate, Brij 35 and chitosan, respectively. FITC-TP 5 can also be absorbed to such an extent ranging from 15 to 28% after intranasal administration of FITC-TP 5 alone, FITC-TP 5 with sodium caprylate, or with bacitracin, respectively. After seven consecutive days multiple dosing, TP 5 formulation with sodium deoxycholate or Brij 35 caused apparently injury to nasal cilia, indicating these two enhancers would not be appropriate for nasal delivery. Results from superoxide dismutase activity, maleic dialdehyde, T-lymphocyte subsets (CD3+, CD4+, CD8+ and CD4+/CD8+ ratio) analyses suggest that all the selected enhancers improve the modulating effects of TP 5 in the immunosuppression rats. On an overall evaluation, intranasal TP 5 alone, TP 5 with chitosan, or TP 5 with bacitracin formulation may be suitable for the future clinical application.

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Section: Discussionsupporting

confidence: 60%

Pharmacokinetics, toxicity of nasal cilia and immunomodulating effects in Sprague–Dawley rats following intranasal delivery of thymopentin with or without absorption enhancers

et al. 2006

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“…Surfactants (Hirai et al 1981), bile salts (Duchateau et al 1986), fatty acids (Mishima et al 1987) and various combinations of bile salts and fatty acids (Tengamnuay and Mitra 1990) have been employed for this function. Although, these systems promote the bioavailability of drugs, ciliotoxicity and damage to the nasal mucosa have been reported (Hirai et al 1981;Tengamnuay and Mitra 1990).…”

Section: Ha In Nasal Deliverymentioning

confidence: 99%

An insight on hyaluronic acid in drug targeting and drug delivery

Yadav

Mishra

Agrawal

2008

Journal of Drug Targeting

111

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Hyaluronic acid (HA) has recently been studied for its use in drug delivery applications. Medically, HA is used as a surgical aid in ophthalmology. It also possesses therapeutic potential in the treatment of arthritis and wound healing. HA-binding receptors, CD44 and receptor for hyaluronan-mediated motility have attracted much enthusiasm, mainly because they are believed to be involved in cancer metastasis. This review unravels the role of HA in drug delivery and targeting. Designing of various novel drug delivery systems using HA as a biopolymer will also be reviewed in the present article.

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“…Dimethylbeta-cyclodextrin was found to be most potent [63,64]. Nasal absorption is also promoted by medium chain fatty acid salt [65] glycyrrhetinic acid derivatives in rat [66] sodium tauro-24, 25-dihydrofusidate in sheep [67]. Etr et al [68] demonstrated that the blood glucose remained low for 3 h after lunch when insulin was used intranasally with 1% deoxycholate in type1 diabetics.…”

Section: B Nasalmentioning

confidence: 99%

Advanced Approaches in Insulin Delivery

Shaikh

Jadhav²,

Ganga

et al. 2005

CPB

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Diabetes is a syndrome of disordered metabolism and inappropriate hyperglycemia resulting from a deficiency of insulin secretion or insulin resistance. Insulin, a pancreatic hormone, helps to lower the blood sugar levels. The structural features of insulin and insulin receptors are summarized. Diabetic patients use insulin in the form of injections, which involves lots of pain, and a need for non-invasive, alternative mode of insulin administration is desired. These challenges have lead to attempts in insulin therapy using oral, nasal, pulmonary, rectal, transdermal, buccal, gene therapy, islet cell transplantation and diabetes vaccine. Among all the approaches pulmonary administration has achieved some clinical significance. Future approaches that can be exploited for insulin therapy in Insulin Dependent Diabetes Mellitus [IDDM] have been summarized. Insulin inhalers or tablets for IDDM are interesting alternatives.

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Studies on the promoting effects of medium chain fatty acid salts on the nasal absorption of insulin in rats.

Cited by 54 publications

References 19 publications

Pharmacokinetics, toxicity of nasal cilia and immunomodulating effects in Sprague–Dawley rats following intranasal delivery of thymopentin with or without absorption enhancers

Pharmacokinetics, toxicity of nasal cilia and immunomodulating effects in Sprague–Dawley rats following intranasal delivery of thymopentin with or without absorption enhancers

An insight on hyaluronic acid in drug targeting and drug delivery

Advanced Approaches in Insulin Delivery

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