1949
DOI: 10.1056/nejm194910062411406
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Studies on the Relation of Pituitary-Adrenal Function to Rheumatic Disease

Abstract: The discovery by

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Cited by 114 publications
(20 citation statements)
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“…Such an increase might have been masked by the large size of the pool in experiment A. L.-2, but in the present experiment, where the pool size was quite small (Table IV) an increase in uric acid production sufficient to account for the uric acid diuresis should have been obvious. These results therefore strongly support the view that ACTH operates predominantly at a renal level and they conform with the views and findings of others (5)(6)(7)(8) as to the mode of action of ACTH and corticoids upon uric acid and explain in part the mechanism of ACTH in the treatment of gout (9)(10)(11)(12).…”
Section: Fig 2 a L Cross Section Of The Patient's Leftsupporting
confidence: 91%
“…Such an increase might have been masked by the large size of the pool in experiment A. L.-2, but in the present experiment, where the pool size was quite small (Table IV) an increase in uric acid production sufficient to account for the uric acid diuresis should have been obvious. These results therefore strongly support the view that ACTH operates predominantly at a renal level and they conform with the views and findings of others (5)(6)(7)(8) as to the mode of action of ACTH and corticoids upon uric acid and explain in part the mechanism of ACTH in the treatment of gout (9)(10)(11)(12).…”
Section: Fig 2 a L Cross Section Of The Patient's Leftsupporting
confidence: 91%
“…Epinephrine acts as a potent eosinopenic agent, whereas nor-epinephrine is devoid of any significant effect. This is in agreement with Thorn's statement which was published subsequent to the inception of this study (3).…”
Section: Commentssupporting
confidence: 93%
“…The recent demonstration of the dramatic therapeutic effectiveness of the adrenal 11, 17-oxysteroids (Compound E of Kendall) in the therapy of rheumatoid arthritis, rheumatic fever, and lupus erythematosus has lent great impetus to the study of the role of the adrenal cortex in these mesenchymal diseases, and to the search for new methods of stimulating the adrenal to produce endogenously these therapeutic agents in greater abundance (1)(2)(3). The wide variety of stimuli capable of producing an "alarm reaction" are all attended by one common factor, the stimulation of the autonomic nervous system with the consequent release of epinephrine (4).…”
mentioning
confidence: 99%
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“…The optimum method of treatment, either systemically or topically, has yet to be determined. 4. Experimental studies confirm the clinical observations.…”
Section: Isupporting
confidence: 71%