Studies on the release of extra‐antral gastrin evidence of vagal inhibition in the dog

Mh, Wheeler; Bhattacherjee, Sharmistha; Psaila, J.V.; McLeish, A. R.; Poxom, V.; Owens, Caroline; Clendinnen, B G; Alexander-Williams, J

doi:10.1007/bf01556195

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…Since gastrin can be released from extra-antral sources [28,29], the small amount of gastrin found inside the bowel after antrectomy may be extra-antral in ori gin.…”

Section: Discussionmentioning

confidence: 99%

Removal of Circulating Gastrin and Cholecystokinin into the Lumen of the Small Intestine

Inoue¹,

Ayalon²,

Yazigi³

et al. 1982

Digestion

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This study was undertaken to investigate the mechanism by which the small intestine removes circulating gastrin and cholecystokinin (CCK). A 100-cm (acute study, 10 dogs) or a 50-cm (chronic study, 5 dogs) segment of midjejunum was excluded in all 15 dogs. The excluded loop was perfused with 0.1 M phosphate buffer (pH 7.4), which was constantly recirculated by a peristaltic pump. In the acute control study (5 dogs), gastrin concentrations in the intestinal perfusate were increased gradually to a level of 320 ± 49 pg/ml at 90 min (i.e., 7.6 ± 0.9 times higher than serum gastrin levels). In the antrectomy group (5 dogs), perfusate gastrin concentrations were greatly decreased after antrectomy, in consonance with the decrease in serum gastrin concentrations. In the chronic study (5 dogs), perfusate gastrin concentrations were significantly increased after food stimulation, in consonance with the increase in serum gastrin concentrations. CCK was also released into the bowel lumen in considerable amounts basally and after endogenous release. Although one cannot exclude the possibility that a considerable amount of gastrin or CCK in the lumen may originate from the bowel segment, this study shows that the small bowel removes gastrin and CCK from the circulation by their secretion into the bowel lumen. Loss of this mechanism might partially explain the rise in gastrin levels that is observed in some patients after extensive small bowel resections.

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“…Since gastrin can be released from extra-antral sources [28,29], the small amount of gastrin found inside the bowel after antrectomy may be extra-antral in ori gin.…”

Section: Discussionmentioning

confidence: 99%

Removal of Circulating Gastrin and Cholecystokinin into the Lumen of the Small Intestine

Inoue¹,

Ayalon²,

Yazigi³

et al. 1982

Digestion

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Effect of an Intravenous Infusion of Aminoacids (Aminoplex 14) on Gastric Secretion in Healthy Subjects and Patients with Duodenal Ulcers

Psaila

Bradley

et al. 1981

Annals of Surgery

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The effect of an intravenous infusion of an aminoacid solution (Aminoplex 14) on gastric secretion is compared in healthy subjects and in duodenal ulcer patients. The acid secretory response was twice as high in duodenal ulcer patients than in normal subjects, 60 minutes after starting the infusion. Serum gastrin levels, although initially higher in duodenal ulcer patients, showed no augmentation throughout the infusion. Blood glucose, serum osmolality and PCV estimations did not alter significantly. Serum aminoacid levels showed a pronounced rise, doubling basal values, and tended to parallel the increase in acid output. Cimetidine, administered orally, suppressed the acid secretory response to intravenous aminoacid. The marked stimulation in acid secretion following aminoacid infusion in duodenal ulcer patients was not elicited after truncal or highly selective vagotomy.

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Non-gastrin, Intestinal-Phase Secretion

Grabner¹,

Pe²,

Et³

et al. 1980

Scandinavian Journal of Gastroenterology

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Four mongrel dogs were prepared with a Heidenhain pouch, a gastric fistula, and a 90-cm-long Thiry-Vella loop. After recovery, dose-response curves were obtained with different doses of pentagastrin, and the maximal acid output was determined. The jejunal loop was perfused for 3 h with either 5% liver extract or with 0.15 M NaCl at a rate of 114 ml/h. To verify that the stomach could release gastrin and that the assay could detect that change, antral perfusion with liver extract was performed. Serum gastrin levels and acid output were measured every 30 min. Perfusion of the jejunal loop with liver extract resulted in a significant increase in acid output from the Heidenhain pouch and the gastric fistula, whereas perfusion with saline solution failed to show any changes. The magnitude of acid response from the Heidenhain pouch and gastric fistula was 11% and 18%, respectively, as compared with maximal pentagastrin stimulation. The serum gastrin levels remained unchanged during both liver extract and saline perfusion of the jejunal loop, in contrast to the marked increase in serum gastrin level after antral perfusion. The results confirm the existence of the intestinal phase of gastric acid stimulation in dogs as an entity and show that the magnitude of this phase is significantly lower than has been suggested by results of earlier studies. Furthermore, the results suggest that the intestinal phase of gastric secretion in dogs is most probably elicited through a humoral agent other than gastrin.

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Studies on the release of extra‐antral gastrin evidence of vagal inhibition in the dog

Cited by 3 publications

References 18 publications

Removal of Circulating Gastrin and Cholecystokinin into the Lumen of the Small Intestine

Removal of Circulating Gastrin and Cholecystokinin into the Lumen of the Small Intestine

Effect of an Intravenous Infusion of Aminoacids (Aminoplex 14) on Gastric Secretion in Healthy Subjects and Patients with Duodenal Ulcers

Non-gastrin, Intestinal-Phase Secretion

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