The life history and biology of C. obsignata in the domestic fowl is described and discussed, together with aspects of the host-parasite relationship. The development of the eggs is shown to be influenced by temperature, humidity, ultra violet radiation and other environmental conditions and these are related to the epidemiology of the parasite. The fowl is susceptible to the development of large numbers of worms, but shows some reaction to very large infective doses. The numbers of worms developing in the host are influenced by the size of the infection and by the age of the host. Large infections produce a consistent depression in weight gain and reduce the efficiency of food conversion. Pathological changes arising from experimental infections are described and compared with those observed in natural infections.