1967
DOI: 10.2170/jjphysiol.17.280
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Studies on the Secretory Potential of Acinal Cell of Dog's Submaxillary Gland and the Ionic Dependency of It

Abstract: Electrophysiological studies by LUNDBURG6-10) have thrown light on the study of the salivary gland of which the secretory mechanism is not known. He found that the membrane potentials of acinal cells of cat's submaxillary gland and sublingual gland are hyperpolarized by stimulation of the chorda tympani, and called this hyperpolarized potential the secretory potential. The origin of these potential changes is not clarified in detail. LUNDBURG has discussed the various possibilities and concluded that the hyper… Show more

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Cited by 31 publications
(16 citation statements)
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“…All these results would however be compatible with the hypothesis that the hyperpolarization was due to an increase in K permeability. This conclusion has, as already mentioned in the introduction, been reached many years ago (Imai, 1965b;Yoshimura & Imai, 1967;Petersen, 1970a, b) but the present evidence is much stronger than that previously presented. However, the question about the mechanism of the ACh-induced membrane hyperpolarization is not solved.…”
Section: Discussionsupporting
confidence: 70%
See 1 more Smart Citation
“…All these results would however be compatible with the hypothesis that the hyperpolarization was due to an increase in K permeability. This conclusion has, as already mentioned in the introduction, been reached many years ago (Imai, 1965b;Yoshimura & Imai, 1967;Petersen, 1970a, b) but the present evidence is much stronger than that previously presented. However, the question about the mechanism of the ACh-induced membrane hyperpolarization is not solved.…”
Section: Discussionsupporting
confidence: 70%
“…It is clear now that there were technical problems in many earlier studies of this kind and that therefore the resting membrane potential had been seriously underestimated (Pedersen & Petersen, 1973). The hypothesis that the physiological transmitter substance acetylcholine (ACh) mainly acts by increasing K and possibly Na permeability of the acinar cell membrane (Imai, 1965 b; Yoshimura & Imai, 1967;Petersen 1970a, b) has been widely accepted, but never rigorously tested (Schneyer, Young & Schneyer, 1972). It appears now that also the activation of the ac-adrenoceptor may be explained in this way (Petersen & Pedersen, 1974).…”
mentioning
confidence: 99%
“…4). Over the whole concentration range the potassium concentration in the secreted juice was identical with, or very slightly higher than, that in the perfusate ( The secretion of lithium A high lithium environment (115 mM) has been shown to reduce dramatically the secretion from the isolated rabbit pancreas (Rothman & Brooks, 1965b), and substitution of lithium for sodium in the fluid perfusing the submaxillary gland virtually abolishes secretion (Yoshimura & Imai, 1967;Petersen & Poulsen, 1969). In the isolated cat pancreas, partial substitution of lithium for sodium also caused a reduction in secretion.…”
Section: Resultsmentioning
confidence: 99%
“…This electrical response is presumably homologous with the secretary potentials that can be recorded from mammalian preparations and since their origin remains somewhat puzzling it was of interest to examine the response in the cockroach. In the mammal the amplitude of the response 724 B. L. GINSBORG, C. R. HOUSE AND E. M. SILINSKY depends on the external ion concentrations as if it were generated by an increase in potassium permeability (Imai, 1965; Yoshimura & Imai, 1967;Petersen, 1970). One way of testing whether a similar mechanism operates in the cockroach gland is to examine the effect of changing the membrane potential of the gland cells during nerve stimulation; in particular, it should be possible to 'invert' the secretory potential by a sufficiently large hyperpolarization.…”
Section: Introductionmentioning
confidence: 99%