Studies on the Separation and Purification of the Caulis sinomenii Extract Solution Using Microfiltration and Ultrafiltration

Abstract

The separation and purification process of alkaloids faces great challenges of pollution, high energy consumption and low continuity. In this study, the effects of ceramic microfiltration (MF) membrane (membrane pore size of 0.50 μm, 0.20 μm, 0.05 μm) and organic ultrafiltration (UF) membrane (membrane molecular weight cut-off of 10 KDa and 1 KDa) on the separation and purification of Caulis sinomenii extract solution in pilot scale were studied. The cleaning effects of different cleaning methods (pure water, 1% HCl-NaOH, 1% sodium hypochlorite) were investigated. The experimental results indicated that 0.05 μm ceramic membrane and 1 kDa UF membrane have higher sinomenine hydrochloride (SH) permeabilities and total solids (TS) removal rates. The ceramic membrane was circulating cleaned by 1% sodium hypochlorite solution for 1 h; the membrane flux can be restored to more than 90% of the original, the membrane flux of 1 kDa UF membrane can be restored to 99.2% of the original by pure water washing. From the above study, the optimal technic parameters was determined in which 0.05 μm ceramic MF membrane and 1 kDa UF membrane were used to separate and purify the Caulis sinomenii extract solution to remove the invalid ingredients, and the two kinds of membranes were cleaned with 1% sodium hypochlorite solution and pure water, respectively, to keep satisfactory membrane fluxes. The study provided an environment-friendly alternative for the separation and purification of alkaloids in natural products, which has a good prospect for the industrial application.

Research progress on extraction technology and biomedical function of natural sugar substitutes

“…In the past, researchers used ceramic microfiltration membrane and organic UF membranes to separate alkaloids from broccoli and found that both membranes maintained good flux after cleaning with 1% sodium hypochlorite solution and pure water, respectively. This study provides a green method to extract alkaloids from natural products and has a good industrial application prospect (61). Secondly, numerous prebiotics fructo-oligosaccharides (FOS) exist in yacon, which not only have potential biological functions for human body, but can also be used as sugar substitutes.…”

A novel approach for sterilization and concentration of traditional functional drinks: Membrane‐based nonthermal processes

“…According to the result of the study on TCM extract, the permeate produced by MF was lighter in color and contained fewer precipitates. Removing foulant from the feed to mitigate membrane fouling led to more efficient MF operation (Wang et al, 2021). Results from the previous study emphasized the applicability of MF as an alternative to the thermal‐based clarification and sterilization processes.…”

A Review on Ultra- and Nanofiltration/Diafiltration Processes of the Food-Oriented Agro-industrial

“…In recent decades, membrane processes have emerged as the forefront technology for separation, purification, and concentration procedures. Pressure-driven membrane separation processes, including Ultrafiltration (UF) and Nanofiltration (NF), have been widely implemented in various industries, such as food and beverage, biotechnology, pharmaceutical, agriculture, and others [8]. Materials used in these technologies are often chemically inert and selected based on their suitability for specific separation processes.…”