Studies on the structural transitions and self-organization behavior of polyacrylic acids with complementary polymers in aqueous solution by laser flash photolysis method using the triplet state of covalently bound phenosafranine

Murugan, K. Durai; Natarajan, P.

doi:10.1016/j.eurpolymj.2011.05.018

Cited by 23 publications

(13 citation statements)

References 49 publications

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“…The incorporation of both acrylic monomers (EHMA and FMCA) into the polymeric networks formed via the photopolymerisation characterizes different sizes and polarities. 7A and B) 68,69 The above observation indicates a lowering of the polarity of the environment of the encapsulated probes compared to that in bulk water. In a protic solvent, the hydrogen bonding plays a significant role in the optical properties of the dye.…”

Section: Synthesis and Characterization Of Polymer Capsulesmentioning

confidence: 82%

Nanocapsules for 5-fluorouracil delivery decorated with a poly(2-ethylhexyl methacrylate-co-7-(4-trifluoromethyl)coumarin acrylamide) cross-linked wall

et al. 2015

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The first synthesis of polymer vesicles with reverse cross-linked walls from poly[2-ethylhexylmethacrylateco-(7-(4-trifluoromethyl)coumarin acrylamide)] P(EHMA/FMCA) is reported. The synthesis, carried out under UV light (l = 350 nm), was achieved via radical photopolymerization of hydrophobic compounds saturating the bilayer of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) liposome template. The polymerization reaction with coumarin moieties has a pivotal role, because the polymer chains become cross-linked as a result of the dimerization of the coumarin side chains of the formed polymers and, in this way, spherical capsules are obtained. Moreover, thanks to the incorporation of coumarin moieties, as an additional bonus, a nanometer-thick porous, fluorescent wall was formed, avoiding the use of additional cross-linking reagents, which might deactivate the encapsulated payloads. We present a new paradigm of release drug delivery systems combining a long shelf-life with the ability for rapid release using external factors such as light. To demonstrate this concept, target compounds such as hydrophilic dyes (Lucifer yellow (LY), phenosafranin (PhS)) and the drug 5-fluorouracil (5-FU)) were incorporated inside the stable, hollow, polymeric nanocapsules. The goal of these applications depends on the versatile strategy that is used for the preparation of highly emissive nanometer-sized polymer capsules with surface functionalities and optical properties for diagnostic applications.

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Section: Synthesis and Characterization Of Polymer Capsulesmentioning

confidence: 82%

Nanocapsules for 5-fluorouracil delivery decorated with a poly(2-ethylhexyl methacrylate-co-7-(4-trifluoromethyl)coumarin acrylamide) cross-linked wall

et al. 2015

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“…Namely, the sample PMAC‐100N‐0.2 showed the highest value of SDeq in PB (Table 3.). This could be explained by the generation of negative charges on the carboxylic groups, [ 9‐11 ] favored at pH of this medium (pH = 6.8) which is above the p K a of PMAA (4.6) and the isoelectric point of casein (pI = 4.6). [ 19,46 ] It could also be noted that the media diffusion coefficients—D M decreased with the increase in the SDeq values, that is, the increase in the MAA neutralization degree (Table 3.)…”

Section: Results and Disscussionmentioning

confidence: 99%

“…[ 8 ] The change of pH value of external medium leads to the change in PMAA conformation: at low pH value of external medium PMAA possesses globular conformation in order to minimize hydrophobic interactions, whereas at high pH value of external medium PMAA chains stretches as a result of ionization of carboxylic groups which further causes chains repulsion. [ 9‐11 ] The biocompatibility, non‐toxicity, as well as the pH sensitivity of PMAA, support the usage of this hydrogel for a targeted delivery and controlled release of drugs in the intestines. Furthermore, this hydrogel is widely used as a drug carrier, in tissue engineering, skin injury treatments.…”

Section: Introductionmentioning

confidence: 95%

Modification of hydrophilic polymer network to design a carrier for a poorly water‐soluble substance

Markovič

Panic

Šešlija

et al. 2020

Polymer Engineering & Sci

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pH sensitive, nontoxic, and biocompatible poly(methacrylic) acid (PMAA) based soft networks have been extensively used in the design of systems for targeted drug delivery. Still, their highly hydrophilic nature limits their potential to be used as a carrier of poorly water-soluble substances. With the aim to overcome this limitation, the present study details a new approach for modification of PMAA based carriers using two amphiphilic components: casein and liposomes. The FTIR analysis revealed structural features of each component as well as the synergetic effect that originated from the formation of specific interactions. Namely, hydrophobic interactions between the poorly watersoluble model drug (caffeine) and casein enabled caffeine encapsulation and controlled release, while addition of liposomes ensured better control of the release rate. The morphological properties of the carriers, swelling behavior, and release kinetics of caffeine were investigated depending on the variable synthesis parameters (neutralization degree of methacrylic acid, concentration of caffeine, presence/absence of liposomes) in two different media simulating the pH environment of human intestines and stomach. The data obtained from in vitro caffeine release were correlated and analyzed in detail using several mathematical models, indicating significant potential of investigated carriers for targeted delivery and controlled release of poorly water-soluble substances.

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“…The absorption spectra of the transient observed on flash photolysis of PMAA bound phenosafranine under acidic conditions (pH < 5.5) reveal the existence of both monoprotonated triplet and diprotonated triplet forms. 88 It is noteworthy that the transient spectrum of triplet-triplet absorption of PMAA bound phenosafranine corresponding to the monoprotonated form shifts towards red region by 40 nm as compared to that of the free dye in aqueous solution. In the flash photolysis experiments, the observed maxima at 740 nm and 830 nm for the transient PMAA-PS + triplet are similar to that observed for the triplet state of the dye in acetonitrile.…”

Section: Flash Photolysis Studies On the Dynamics Of Pmaa Using Triplmentioning

confidence: 95%

Photoprocesses of coordination compounds and dyes in solution and nanoporous materials: Evolution from milliseconds to femtoseconds#

2011

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The photoredox reactions of cobalt(III), nickel(II) complexes and organic dyes are reviewed with particular emphasis on using flash photolysis methods to identify the transients in the time scale from milliseconds to subpicoseconds. The excitation flash radiation initially was limited to flash lamps with a time resolution to study the decay of the excited states and the fast reactions of photo produced transients in milliseconds and microseconds. Some of the photolysis reactions investigated provide details in real time including the thermal reactions of molecular oxygen with cobalt(II) amine systems and the cobalt (III) alkyl complex formation on photolysis of cobalt(III) aminoacid complexes. Photoredox reactions of thiazine and safranine dyes are investigated using time resolved absorption and emission techniques in solution and on encapsulation in micro and mesoporous host materials. Picosecond and femtosecond diffuse reflectance fluorescence investigations in the porous solid host materials show intramolecular proton transfer reactions of the dyes and deprotonation of the dyes in the excited states. Photosensitization of nanoparticles of semiconductors, anatase TiO 2 and ZnO by the excited states of dyes in meso and microporous silicate hosts is investigated using pico and femtosecond fluorescence and transient absorptions techniques and the results are reviewed.

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Studies on the structural transitions and self-organization behavior of polyacrylic acids with complementary polymers in aqueous solution by laser flash photolysis method using the triplet state of covalently bound phenosafranine

Cited by 23 publications

References 49 publications

Nanocapsules for 5-fluorouracil delivery decorated with a poly(2-ethylhexyl methacrylate-co-7-(4-trifluoromethyl)coumarin acrylamide) cross-linked wall

Nanocapsules for 5-fluorouracil delivery decorated with a poly(2-ethylhexyl methacrylate-co-7-(4-trifluoromethyl)coumarin acrylamide) cross-linked wall

Modification of hydrophilic polymer network to design a carrier for a poorly water‐soluble substance

Photoprocesses of coordination compounds and dyes in solution and nanoporous materials: Evolution from milliseconds to femtoseconds#

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