1981
DOI: 10.1002/art.1780240408
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STUDIES ON TYPE II COLLAGEN–INDUCED POLYARTHRITIS IN RATS. Effect of Antiinflammatory and Antirheumatic Agents

Abstract: The effect of a variety of antiinflammatory and antirheumatic agents on both developing and established lesions of type I1 collagen induced polyarthritis in rats was examined. Administration of the nonsteroidal antiinflammatory agents indomethacin or phenylbutazone suppressed the paw inflammation associated with the disease without affecting type I1 collagen antibody titers. Radiographic analysis of the joints showed suppression of several parameters related to joint destruction. This was most probably related… Show more

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Cited by 70 publications
(33 citation statements)
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“…Immunosuppressive and anti-inflammatory substances are only of limited value and have serious side effects (1,2). In animal models, collagen-induced arthritis (CIA) and relapsing experimental allergic encephalomyelitis (REAE), drugs such as cyclosporin A and cyclophosphamide suppress only when administered during induction of the disease (3)(4)(5)(6)(7)(8)(9)(10). Biological agents that can suppress the inflammatory effects of interleukin 1 (IL-1) and tumor necrosis factor a (TNF-a), cytokines that increase the severity of autoimmune diseases in animal models (11), deserve attention as alternative approaches.…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…Immunosuppressive and anti-inflammatory substances are only of limited value and have serious side effects (1,2). In animal models, collagen-induced arthritis (CIA) and relapsing experimental allergic encephalomyelitis (REAE), drugs such as cyclosporin A and cyclophosphamide suppress only when administered during induction of the disease (3)(4)(5)(6)(7)(8)(9)(10). Biological agents that can suppress the inflammatory effects of interleukin 1 (IL-1) and tumor necrosis factor a (TNF-a), cytokines that increase the severity of autoimmune diseases in animal models (11), deserve attention as alternative approaches.…”
mentioning
confidence: 99%
“…In this respect it may differ from immunosuppressive drugs. Cyclophosphamide can suppress the development of EAE or CIA, when given early during the immunization (4,5), but can provoke relapses in rats that have recovered from EAE (40). Moreover, cyclosporin A suppresses CIA when given early but augments the disease when given late during 1/11 (9) 70 0.1 ± 0.3…”
mentioning
confidence: 99%
“…GCs are widely used clinically against a variety inflammatory diseases including RA 23 . However, when used in the treatment of RA, GCs can cause secondary osteoporosis 1,[24][25][26] .…”
Section: Discussionmentioning
confidence: 99%
“…Recently, bisphosphonates have been evaluated in clinical trials for the treatment of RA, one of the most severe diseases causing progressive joint damage 22 . On the other hand, steroidal anti-inflammatory agents have been found to suppress paw inflammation in type II collagen-induced arthritis rats, and glucocorticoids (GCs) are widely used clinically against a variety inflammatory diseases 23 . GCs have a broad spectrum of mechanisms by which they inhibit various inflammatory reactions.…”
Section: Introductionmentioning
confidence: 99%
“…clinical differences between the animal model and human diseases (8,9,11,12). Many recent studies indicate that only a minority of patients with RA have significant circulating levels of antibodies to native type I1 collagen (13)(14)(15)(16).…”
Section: Collier Et Almentioning
confidence: 99%