Studies on wild house mice VI: Differential effects of the Y chromosome on intermale aggression

Sluyter, Frans; Oortmerssen, G.A. van; Koolhaas, Jaap M.

doi:10.1002/1098-2337(1994)20:5<379::aid-ab2480200505>3.0.co;2-b

Cited by 23 publications

(3 citation statements)

References 15 publications

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“…The results showed that although exposure to testosterone had a slight aggression-enhancing effect on TNA males, the difference between the experimental and control (injected with peanut oil) groups did not reach significant levels. The literature on the involvement of the Y chromosome has been somewhat inconsistent, and evidence has been presented which suggests that in some strains and lines of mice the genes that influence aggressive behavior might be situated on the Y chromosome (Maxson, 1981;Maxson et al, 1983;van Oortmerssen and Sluyter, 1994;Sluyter et al, 1994). These results are at least partially in line with the findings of Compaan and her co-workers (1992), who used two selection lines of wild house mice.…”

Section: Neonatal Hormonal Treatmentmentioning

confidence: 55%

Selective breeding for isolation-induced intermale aggression in mice: Associated responses and environmental influences

1996

Behav Genet

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Aggressive (TA) and nonaggressive (TNA) lines of mice were established by selective breeding for isolation-induced intermale aggression. This paper summarizes and updates studies performed on the TA and TNA lines. The genetic analysis revealed that in these lines the genes for aggression are located on the autosomes and demonstrate a Mendelian segregation. The genes are expressed only in the presence of androgens which are normally present only in males. Behavioral and biological responses associated with high and low levels of aggression in TA and TNA mice are reviewed. Line differences have been found in olfactory communication and marking behavior, in maternal and predatory aggression in females, in locomotor activity, and in learning abilities. Also, correlated neurochemical and endocrinological responses to the selection have been detected. Maternal factors during the preweaning period do not significantly affect the development of aggression in TA and TNA males, while early postweaning exposure to aggression or sex enhanced later aggressive and sexual activity. Early experience and genetic disposition for aggression are correlated, with TA males showing the greatest increase in the behaviors studied.

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Section: Neonatal Hormonal Treatmentmentioning

confidence: 55%

Selective breeding for isolation-induced intermale aggression in mice: Associated responses and environmental influences

1996

Behav Genet

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“…There arc Y chromosome effects on brain and behavior of male mice. They include effects on hippocampal weight (23), asymmetry in hippocampal size (23), hippocampal mossy fiber distribution (24), whole brain levels of serotonin (25) and dynorphin (26), open Held behavior (27), circadian rhythms (28), coping strategies (29), apomorphinc-induced stereotypy (30), copulatory behaviors (31,32), aggressive behavior (33)(34)(35), and discrimination learning (23). Reciprocal Fls, segregating populations, and congenic strains have been used in these studies.…”

Section: Ychromosomementioning

confidence: 99%

Sex differences in genetic mechanisms for mammalian brain and behavior

Maxson

1997

Biomedical Reviews

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• There are sex specific genetic mechanisms for mammalian brain and behavior. These are genes that act differently in each sex. They may underlie either similarities or differences in brain and behavior of males andfernales. Some of these genes are autosomal. Others are located on the non-recombining part of the Y chromosome. Genes on this region of the Y chromosome may contribute to sex differences in brain and behavior in three ways. First, a gene may be on the Y chromosome and not on any other chromosome. Thus, it acts only in males. Sex-determining region on the Y chromosome (Sry) is such a gene. Second, there may be different isoforms of proteins coded for by the gene on the Y chromosome and by its homologue located elsewhere in the genome. Such a gene is Smcy which codes for an H-Yantigen. Smcx is its X-chromosomal homologue. Third, there may be different protein levels in males and females for a gene located on the X and Y chromosomes. Zfy and Zfx, for the zinc finger proteins on the Y and on the X, are a pair of such genes. Due to X inactivation in females, one copy of Zfx is expressed in all tissues of female mice, whereas two copies, one of Zfx and one of Zfy, are expressed in many tissues of male mice.

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“…Both genetic and environmental factors contribute to the manifestation of aggression in male house mice. Genetic studies have suggested that at least two sex‐linked and several autosomal loci are associated with variation in fighting behavior [Brodkin et al, 2002; Roubertoux et al, 2005; Selmanoff et al, 1975; Sluyter et al, 1994]. At the individual level, the outcome of male aggression is modulated by a variety of non‐genetic factors, such as hormonal induction (linked to fetal intrauterine position [Ryan and Vandenbergh, 2002]), hormonal and neurochemical changes [Caramaschi et al, 2008a, b; Natarajan et al, 2009a], pre‐ and postnatal maternal effects [Sluyter et al, 1995], and social environment after weaning [e.g.…”

Section: Introductionmentioning

confidence: 99%