Studies towards investigation of Naphthoquinone-based scaffold with crystal structure as lead for SARS-CoV-19 management

Visible-Light-Mediated Catalyst-Free [2+2] Cycloaddition Reaction for Dihydrocyclobuta[b]naphthalene-3,8-diones Synthesis under Mild Conditions

“…Furthermore, owing to the high chemical reactivity from the inherent and high ring strain, the fused cyclobutenes experience diverse transformations, ring-opening and ring-expansion reactions in particular, providing distinctive approaches to the construction of complex organic molecules [10][11][12][13]. Dihydrocyclobuta [b] naphthalene-3,8-diones (DHCBNDOs) containing fused cyclobutene structures are highly valued scaffolds that occur in many bioactive compounds (Figure 1) and, in particular, operate as lead compounds for SARS-CoV-19 management, [14] miR-1 inhibitors [15], and microRNAs activators [16]. A great deal of attention has been devoted to developing better strategies for synthesizing DHCBNDOs and their analogs, of which [2+2] cycloaddition is generally considered to be one of the most forthright and efficient methods [17][18][19][20][21].…”

“…A great deal of attention has been devoted to developing better strategies for synthesizing DHCBNDOs and their analogs, of which [2+2] cycloaddition is generally considered to be one of the most forthright and efficient methods [17][18][19][20][21]. The DHCBNDOs, an interesting scaffold for developing new drugs for SARS-CoV-19, coronary artery diseases, heart attacks and miRNA-based tumors, are underrepresented in medicinal chemistry [14][15][16], and this potentially results from deficiencies in extant synthetic methodologies.…”

“…tumors, are under-represented in medicinal chemistry [14][15][16], and thi from deficiencies in extant synthetic methodologies. As shown in Scheme 1, the DHCBNDO system has only recentl by formal [2+2] cycloaddition under reflux condition, as reported by and coworkers [22][23][24].…”