Studies with Brugia pahangi—I. parasitological observations on primary infections of cats (Felis catus)

Denham, D. A.; Ponnudurai, T.; Nelson, G. S.; Guy, Frances; Rogers, Rosemary

doi:10.1016/0020-7519(72)90012-4

Cited by 57 publications

(36 citation statements)

References 14 publications

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“…Patency commences at 53 to 94 days p.i., increases over the first year, and plateaus at 1 year p.i. in repeatedly infected cats (72,73). While MF levels in repeatedly infected cats are variable, ranging from 50 to 40,000 MF/ml, almost all infected cats develop microfilaremia (73).…”

Section: Brugia Pahangimentioning

confidence: 99%

“…Cats are permissive to infection. Ninety-six percent of cats experimentally infected with B. pahangi become microfilaremic (72). Male and female cats are equally susceptible to infection, with an average of 8 to 25% of injected larvae surviving to adulthood (73)(74)(75).…”

Section: Brugia Pahangimentioning

confidence: 99%

“…Infection in the foot results in an enlarged popliteal lymph node and dilated, swollen, varicosed lymphatic vessels (74,78). Although lymph nodes and vessels become fibrotic over time in infected cats, collateral channels form in response to fibrosis, and only a minority of cats develop frank lymphedema of infected limbs (72,79).…”

Section: Brugia Pahangimentioning

confidence: 99%

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A Comprehensive, Model-Based Review of Vaccine and Repeat Infection Trials for Filariasis

et al. 2013

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SUMMARY Filarial worms cause highly morbid diseases such as elephantiasis and river blindness. Since the 1940s, researchers have conducted vaccine trials in 27 different animal models of filariasis. Although no vaccine trial in a permissive model of filariasis has provided sterilizing immunity, great strides have been made toward developing vaccines that could block transmission, decrease pathological sequelae, or decrease susceptibility to infection. In this review, we have organized, to the best of our ability, all published filaria vaccine trials and reviewed them in the context of the animal models used. Additionally, we provide information on the life cycle, disease phenotype, concomitant immunity, and natural immunity during primary and secondary infections for 24 different filaria models.

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Section: Brugia Pahangimentioning

confidence: 99%

Section: Brugia Pahangimentioning

confidence: 99%

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A Comprehensive, Model-Based Review of Vaccine and Repeat Infection Trials for Filariasis

et al. 2013

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“…Ref : Schacher, 1962Zaini et al, 1962;Ramachandran & Pacheco, 1965;Ahmed, 1966;Schacher & Sahyoun. 1967;Ash & Riley, 1970a;Denham et al, 1972;Ah & Thompson. 1973;Kowalski & Ash.…”

Section: Monanema Martinimentioning

confidence: 99%

“…With the Brugia species, the procedures of inoculation were often special in order to favour the lymphatic system of the legs and the testicular region for the eventual locali sation of the adults : larvae were inoculated in the inguinal region (Ash & Riley, 1970a), or scrotal region, or into the dorsum of the hind foot (Denham et al, 1972), after several puncture wounds (Ewert, 1971). In our other experiments, all infective larvae (L3) were inoculated subcutaneously into the right lumbar area of rodents three to four week old.…”

Section: Inoculation Of Rodentsmentioning

confidence: 99%

Larval biology of six filariae of the sub-family Onchocercinae in a vertebrate host

Bain

Wanji

Vuong³

et al. 1994

Parasite

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Summary:The development of six filariae of the sub-family OnchocercinaeLitomosoides sigmodontis, Acanthocheilonema viteoe, Molinema dessetae, Monanema martini, Brugia malayi, B. pahangi -was compared in rodents, following a single inoculation of a low or high dose of infective larvae. Analysis was done with 105 rodents dissected and 53 rodents fixed for histopathology.The percentage of larvae which developed corresponded to the proportion of those which were able to penetrate Into the sub-cutaneous lymphatic vessels; this percentage was determined during the first day (phase 1) and was characteristic of the filaria-host pair, and independent of the number of larvae inoculated. It could remain stable for a long time, more than eight months with M. martini (phase 2); the phenomena of regulation appeared later (phase 3).The larvae migrated through the lymphatic system, which represents a medium less protected and thus less agressive than the blood system. The coelomic cavities, almost devoid of inflammatory cells, represented an ultimate shelter, as well as the joint-cavities (colonized by some Dirofilariinae). Localizations in the cardio-pulmonary blood system were accidental and occurred when, during the migrations, some larvae penetrated into the thoracic channel and arrived in the superior vena cava, then the right ventricle and the pulmonary arteries (the biology of Dirofilaria immitis resulted in a secondary adaptation); such accidents may occur with adult filariae, especially after drug treatment. One may expect similar events in human filariasis. These "occult" filariae, more frequent than it is usually thought, influence the immunological status and the pathology.T he larval biology of filariae obviously cannot be elucidated in humans. However, by multi plying the observations of various filariae in small rodents, several rules arise, so general, that it seems rational to presume their validity in human fila riases. Six species of Onchocercinae were studied. The experiments were performed using similar procedures to allow comparisons. By a double analysis -dissec tion of rodents and histopathology-we tried to deter mine the quantitative relationships between larvae inoculated and filariae recovered, and to follow the migrations.

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The Nematodes

2002

Feline Clinical Parasitology

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Studies with Brugia pahangi—I. parasitological observations on primary infections of cats (Felis catus)

Cited by 57 publications

References 14 publications

A Comprehensive, Model-Based Review of Vaccine and Repeat Infection Trials for Filariasis

A Comprehensive, Model-Based Review of Vaccine and Repeat Infection Trials for Filariasis

Larval biology of six filariae of the sub-family Onchocercinae in a vertebrate host

The Nematodes

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