Studies with Radioiodine

Miller, Earl R.; Dailey, Morris O.; Holmes, AP; Alexander, George L.; Sheline, Glenn E.

doi:10.1148/57.1.37

Cited by 9 publications

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“…In thyrotoxicosis the turnover is much faster and peak neck uptakes occur most often at 3-5 hours after the dose (Miller et al, 1951) so that uptakes at later times may be misleading. Similarly the 48 hours PBI3II, of little use in normals, is of established value in the diagnosis of thyrotoxicosis (Wayne, 1960).…”

Section: Tbe Measurement Of Abnormal Thyroid Activitymentioning

confidence: 99%

¹³²Iodine in Thyroid Function

Hobbs

1962

Proceedings of the Association of Clinical Biochemists

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Section: Tbe Measurement Of Abnormal Thyroid Activitymentioning

confidence: 99%

¹³²Iodine in Thyroid Function

Hobbs

1962

Proceedings of the Association of Clinical Biochemists

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THYROTROPIC HORMONE IN INFANTS AND CHILDREN<subtitle>Differentiation Between Primary and Hypopituitary Hypothyroidism</subtitle>

Pickering¹,

Miller²

1953

Arch Pediatr Adolesc Med

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Thyroidal Accumulation of Radioiodine in Children

Sheline¹

1957

Arch Pediatr Adolesc Med

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Although a large volume of information on the radioiodine uptake by the thyroid of the adult is available, there is relatively little such information concerning the infant and child. For the most part, published data for the child or infant relate to the normal or hypothyroid person and pertain to the period between 24 and 96 hours following the administration of the radioiodine test dose.The present study concerns the thyroid uptake of radioiodine as a function of the status of the thyroid gland, the age of the patient, and the time after the administration of the test dose. It provides data on the effect of the thyroid-stimulating hormone (TSH) on thyroidal accumulation of radioiodine in the euthyroid, the primary hypothyroid, and the pituitary hypothyroid child.In a recent paper by Martmer, Corrigan, Charbeneau, and Sosin,1 the 24-hour radioiodine uptake in 65 premature infants was reported as being within the limits of normal for children and adults. Middles-worth2 found that the 24-hour uptake of radioiodine in the 1to 3-day-old normal full-term infant ranged between 46% and 97% of the administered dose. In the adult such high levels would be indicative of hyperthyroidism. Quimby and Medine3 studied the thyroid uptake of radioiodine at 48 hours in 54 children under the age of 15 years. Thirty-three were euthyroid and showed an average 48-hour uptake of 12.0%, with a range from 4% to 20%; there was no discernible relationship be-tween uptake and age of the child. Five children who were clearly hypothyroid showed uptakes of less than 1%, and two children who were clearly thyrotoxic had uptakes of 34% and 60%, respectively. Reilly and Bayer,4 in a study of thyroid up¬ take and urinary excretion of I131 in 25 euthyroid children and in 5 congenitally hypothyroid children, found the maximum uptake to occur between 24 and 48 hours and showed that the normal thyroid took up from 8% to 30% of the administered dose, while the uptake in the thyroid of the cretinous children was between 1% and 2%. Methods and MaterialsThe present series includes all patients under the age of 18 years studied in the Radioiodine Laboratory at the University of California School of Medicine for whom adequate records were available.* Thirty-four euthyroid, sixteen primary hypothyroid, sixteen pituitary or secondary hy¬ pothyroid. and seventeen hyperthyroid children were studied. In each case the clinical record was carefully reviewed. The final diagnosis was based on the clinical evaluation, the serum protein-bound iodine level, the bone age, and, in some cases, on the clinical response to thyroid therapy. The radio¬ iodine uptake and the response to thyrotropic hor¬ mone were not used in arriving at the diagnosis. The euthyroid group was composed chiefly of children who were of small stature but had no other abnormality, were mentally retarded, or had Legg-Perthes' disease ; all appeared to have normal thyroid function. The primary hypothyroid group included those with evidence of hypothyroidism but with no clinical or laboratory evidence...

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Studies with Radioiodine

Cited by 9 publications

References 0 publications

¹³²Iodine in Thyroid Function

¹³²Iodine in Thyroid Function

THYROTROPIC HORMONE IN INFANTS AND CHILDREN<subtitle>Differentiation Between Primary and Hypopituitary Hypothyroidism</subtitle>

Thyroidal Accumulation of Radioiodine in Children

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Studies with Radioiodine

Cited by 9 publications

References 0 publications

132Iodine in Thyroid Function

132Iodine in Thyroid Function

THYROTROPIC HORMONE IN INFANTS AND CHILDREN<subtitle>Differentiation Between Primary and Hypopituitary Hypothyroidism</subtitle>

Thyroidal Accumulation of Radioiodine in Children

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¹³²Iodine in Thyroid Function

¹³²Iodine in Thyroid Function