Study about Frequency of Carotid Intima- Media Thickness versus Aortic Intima- Media Thickness in Patients with Non Alcoholic Fatty Pancreatic Disease

Abstract

Background: Non-alcoholic fatty pancreatic disease (NAFPD) or fatty pancreas emerged as health problem parallel to obesity. NAFPD can lead to diabetes mellitus, chronic pancreatitis and lastly pancreatic cancer. Extra pancreatic complications to cardio-vascular system are reported to more than expected. Aim: To investigate the association between carotid and aortic intima-media thickness and non-alcoholic fatty pancreas disease. Method: eighty-eight patients divided into 4 groups , group (1)diabetics with normal Body Mass Index( BMI) , group (2) diabetics with BMI over 25 kg/m 2 , group(3) non-diabetics with normal BMI , group (4) non diabetics with BMI over 25kg/m 2 . All routine investigations necessary done including, Complete Blood Count (CBC), fasting blood sugar , HbA1c%, liver profile including (ALT , AST , GGT , ALP , serum bilirubin and serum albumin) , lipid profile including (cholesterol , triglycerides , HDL , and LDL) , serum insulin level . Abdominal ultrasound for diagnosis, grading of fatty pancreas and measure Cartotid Intima Media Thickness( CIMT) and Aortic Intima Media Thickness (AIMT). Result: AIMT was as follow (0.96-+0.26) for healthy normal ,(1.38-+0.20)for non DM -obese,(1.24-+0.18)DM , non-obese and (1.52-+0.37) for DM -obese patients respectively with p value between the groups =<0.001.CIMT was as follow (0.58-+0.18) for healthy normal ,(0.73-+0.18)for non DM -obese,(0.86-+0.20)DM , non-obese and (1.01-+0.25) for DM -obese patients respectively with p value between the groups =<0.001 Conclusion: Both AIMT and CIMT manifested in the patients groups even the normal healthy subjects which is