Aluminum-based cellular solids are promising lightweight structural materials considering their high specific strength and vibration damping, being potential candidates for future railway vehicles with enhanced riding comfort and low fuel consumption. The filling of these lattices with polymer-based (i.e., polyurethane) foams may further improve the overall vibration/noise-damping without significantly increasing their density. This study explores the dynamic (i.e., frequency response) and acoustic properties of unfilled and polyurethane-filled aluminum cellular solids to characterize their behavior and explore their benefits in terms of vibration and noise-damping. It is shown that polyurethane filling can increase the vibration damping and transmission loss, especially if the infiltration process uses flexible foams. Considering sound reflection, however, it is shown that polyurethane filled samples (0.27–0.30 at 300 Hz) tend to display lower values of sound absorption coefficient relatively to unfilled samples (0.75 at 600 Hz), is this attributed to a reduction in overall porosity, tortuosity and flow resistivity. Foam-filled samples (43–44 dB at 700–1200 Hz) were shown to be more suitable to reduce sound transmission rather than reflection than unfilled samples (21 dB at 700 Hz). It was shown that the morphology of these cellular solids might be optimized depending on the desired application: (i) unfilled aluminum cellular solids are appropriate to mitigate internal noises due to their high sound absorption coefficient; and (ii) PU filled cellular solids are appropriate to prevent exterior noises and vibration damping due to their high transmission loss in a wide range of frequencies and vibration damping.