The deepening penetration of Distributed Energy Resources (DERs) into Distribution Networks (DNs) is causing relevant issues to be addressed by Distribution System Operators (DSOs), such as quality of service, security and safety, both at Medium Voltage (MV) and Low-Voltage (LV) distribution levels. This paper presents how A2A Reti Elettriche SpA, an Italian DSO, had addressed those challenges launching a set of research activities in different areas of the distribution automation. Results collected during field experiences have been used to design the reference model of the next generation of DN Secondary Substations (SS).