Study of 223Ra uptake mechanism by Fe3O4 nanoparticles: towards new prospective theranostic SPIONs

Facile and greener hydrothermal honey‐based synthesis of Fe3O4/Au core/shell nanoparticles for drug delivery applications

“…[29][30][31] As shown in Figure 8, the synthesized Fe 3 O 4 /Au-NPs were found to be nonsignificant toxic to the cells in higher concentration up to 140.0 ppm which are used in the biological applications were well tolerated by WEHI164 cells in the MTT assay. Briefly, in 96 well plates, WEHI164 fibro sarcoma cells (1 × 10 4 cells/well) supplied from Institute Pastor, Iran, were seeded and incubated for 24 hours at 37°C in 5% CO 2 incubator.…”

An overview of nanoscale radionuclides and radiolabeled nanomaterials commonly used for nuclear molecular imaging and therapeutic functions

“…Radium-223 ( 223 Ra) is a first-in-class alpha-emitting radionuclide approved by the US Food and Drug Administration and European Medicines Agency for the treatment of bone metastases originating from castration resistant prostate cancer. 176 However, the data published on the 223 Ra labeled magnetic NPs in theranostic applications is quite limited. Mokhodoeva and co-workers 176 focused on the study of 223 Ra uptake mechanism by Fe 3 O 4 NPs.…”

“…176 However, the data published on the 223 Ra labeled magnetic NPs in theranostic applications is quite limited. Mokhodoeva and co-workers 176 focused on the study of 223 Ra uptake mechanism by Fe 3 O 4 NPs. In addition, they discussed the potential use of 223 Ra labeled supermagnetic NPs in theranostic applications.…”

Radiolabeled Nanoparticles in Nuclear Oncology

“…Mokhodoeva et al investigated the direct labeling of SPIONs with 223 Ra, the first alpha-emitting radioisotope with FDA approval for clinical application. It was demonstrated that the [ 223 Ra]Fe3O4 NPs retained their radiolabel for up to 24 h post-preparation, while in vitro stability studies in PBS, bovine plasma and serum at 11.4 and 22.8 days showed a maximum average 223 Ra release of 5%, rendering these NPs suitable for further in vivo testing [121]. The group of Piotrowska A. et al (2017) utilized type A nanozeolite nanoparticles containing sodium, which were linked to an NK-1 receptor-targeting peptide.…”