Study of 7 Cases of Giant Cell Tumor of Soft Tissue

Chand, Kailash; Bhardwaj, RK; Rappai, TJ

doi:10.1016/s0377-1237(06)80056-0

Cited by 14 publications

(15 citation statements)

References 8 publications

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“…4,5 This underscores the need to ensure a tumour free margin post excision and follow up of patients, as the tumour biology of this lesion is not completely known. It affects mainly adults of both sexes, 2 in keeping with our female patient aged 58 years. Oliveria et al reported an age range of 5-80 years (median 43 years), 5 while Tagera-Vaquerizo et al reported an age range of 5-84 years, 8 both with no predilection for sex.…”

Section: Discussionsupporting

confidence: 76%

“…6 The histogenesis of this tumour is not certain, but it is postulated that osteoclast-like cells are the result of fusion of circulating monocytes recruited into the lesion. 2,8 Giant cell tumour of soft tissue though predominantly a benign condition, demonstrates unpredictable capacity to occasionally recur or evolve into a malignant lesion. 2 Reported recurrence rate is 6.2%, though infrequent, metastasis to the lungs and parotid glands have been described.…”

Section: Discussionmentioning

confidence: 99%

“…2,8 Giant cell tumour of soft tissue though predominantly a benign condition, demonstrates unpredictable capacity to occasionally recur or evolve into a malignant lesion. 2 Reported recurrence rate is 6.2%, though infrequent, metastasis to the lungs and parotid glands have been described. 4,5 This underscores the need to ensure a tumour free margin post excision and follow up of patients, as the tumour biology of this lesion is not completely known.…”

Section: Discussionmentioning

confidence: 99%

“…They present frequently as skin tumour and may be superficial as the case presented, or may be in deep body tissue. 2 Painless, firm, mobile, well-demarcated mass, not attached to muscle, tendon, or bone is the common mode of presentation. 4 There are no reported gross features that distinguish between benign and malignant variants.…”

Section: Discussionmentioning

confidence: 99%

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Giant cell tumor of right thumb: a rare case report

et al. 2015

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Giant cell tumor of right thumb: a rare case report

et al. 2015

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“…Metastasis to other organs is rare after multiple recurrences [6][7]. These tumors present as painless growing masses [8,9] with an average duration of symptoms of 6 months [8,9]. No etiological factors have been identified [5].…”

Section: Discussionmentioning

confidence: 99%

Tenosynovial Giant Cell Tumor of the thigh

Salhi¹,

Jaïdane²,

Hassouna³

et al. 2017

int arch med

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Tenosynovial giant cell tumors (TGCT) are a group of generally benign intra-articular and soft tissue tumors with common histological features. TGCT is also known as pigmented villonodular synovitis. There are localized and diffuse forms. Localized types include giant cell tumors of tendon sheath and localized pigmented villonodular synovitis, whereas diffuse types encompass conventional pigmented villonodular synovitis and diffuse type giant cell tumor. Localized tumors are generally indolent, whereas diffuse tumors are locally aggressive.In this article, we report the case of a diffuse-type extra-articular TGCT found in the left thigh of a 73-year-old woman who presented with a painless but gradually progressive swelling in the left thigh since eighteen months. On examination, there was a soft cystic swelling measuring 22 cm. The swelling was fixed to the underlying soft tissues. She had a Computed Tomography scan of the left thigh showing a mass of fluid density, well encapsulated between the muscles of the thigh, measuring 20x10 cm of major axes, compressing the femoral vessels without invading them. The patient had a complete marginal resection of the tumor. The immune-histopathological findings were consistent with those of a diffuse type of Giant Cell Tenosynovial Tumor. At 18 months follow-up, the patient is asymptomatic with no evidence of disease recurrence.The extra-articular diffuse type TGCT is more aggressive than the localized type. Although these tumors are benign in the majority of cases, malignant transformation has been reported. Therefore, close follow-up is recommended after tumor excision.

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