Study of a high resolution, 3-D positioning cross-strip Cadmium Zinc Telluride detector for PET

Gu, Yi; Matteson, J. L.; Skelton, R. T.; Deal, Aaron C.; Stephan, Edwin A.; Duttweiler, Fred; Gasaway, Thomas M.; Levin, Craig S.

doi:10.1109/nssmic.2008.4774098

Cited by 11 publications

(14 citation statements)

References 4 publications

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“…In [2], the coincidence timing resolution of two LSO-PSAPD detectors was shown to be 15.5 ns full-width at half-maximum (FWHM), similar to the time resolution reported for the RENA-3 in [7] and [9]. The timing resolution for other PMT-based breast dedicated PET imaging systems is under 10 ns FWHM: 1.2 ns [10], 5.2 ns [11], and 8.1 ns [12].…”

Section: Introductionsupporting

confidence: 63%

Convex Optimization of Coincidence Time Resolution for a High-Resolution PET System

Reynolds

Olcott

Pratx

et al. 2011

IEEE Trans. Med. Imaging

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We are developing a dual panel breast-dedicated positron emission tomography (PET) system using LSO scintillators coupled to position sensitive avalanche photodiodes (PSAPD). The charge output is amplified and read using NOVA RENA-3 ASICs. This paper shows that the coincidence timing resolution of the RENA-3 ASIC can be improved using certain list-mode calibrations. We treat the calibration problem as a convex optimization problem and use the RENA-3’s analog-based timing system to correct the measured data for time dispersion effects from correlated noise, PSAPD signal delays and varying signal amplitudes. The direct solution to the optimization problem involves a matrix inversion that grows order (n3) with the number of parameters. An iterative method using single-coordinate descent to approximate the inversion grows order (n). The inversion does not need to run to convergence, since any gains at high iteration number will be low compared to noise amplification. The system calibration method is demonstrated with measured pulser data as well as with two LSO-PSAPD detectors in electronic coincidence. After applying the algorithm, the 511 keV photopeak paired coincidence time resolution from the LSO-PSAPD detectors under study improved by 57%, from the raw value of 16.3 ± 0.07 ns full-width at half-maximum (FWHM) to 6.92 ± 0.02 ns FWHM (11.52 ± 0.05 ns to 4.89 ± 0.02 ns for unpaired photons).

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Section: Introductionsupporting

confidence: 63%

Convex Optimization of Coincidence Time Resolution for a High-Resolution PET System

Reynolds

Olcott

Pratx

et al. 2011

IEEE Trans. Med. Imaging

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“…(b) Illustration of a box-shape CZT-based small animal PET system of 8×8×8 cm 3 field-of-view. (Adapted from [30, 31, 33]. …”

Section: Fig (1)mentioning

confidence: 99%

Recent Developments in PET Instrumentation

Peng

Levin²

2010

CPB

101

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Positron emission tomography (PET) is used in the clinic and in vivo small animal research to study molecular processes associated with diseases such as cancer, heart disease, and neurological disorders, and to guide the discovery and development of new treatments. This paper reviews current challenges of advancing PET technology and some of newly developed PET detectors and systems. The paper focuses on four aspects of PET instrumentation: high photon detection sensitivity; improved spatial resolution; depth-of-interaction (DOI) resolution and time-of-flight (TOF). Improved system geometry, novel non-scintillator based detectors, and tapered scintillation crystal arrays are able to enhance the photon detection sensitivity of a PET system. Several challenges for achieving high resolution with standard scintillator-based PET detectors are discussed. Novel detectors with 3-D positioning capability have great potential to be deployed in PET for achieving spatial resolution better than 1 mm, such as cadmium-zinc-telluride (CZT) and position-sensitive avalanche photodiodes (PSAPDs). DOI capability enables a PET system to mitigate parallax error and achieve uniform spatial resolution across the field-of-view (FOV). Six common DOI designs, as well as advantages and limitations of each design, are discussed. The availability of fast scintillation crystals such as LaBr3, and the silicon photomultiplier (SiPM) greatly advances TOF-PET development. Recent instrumentation and initial results of clinical trials are briefly presented. If successful, these technology advances, together with new probe molecules, will substantially enhance the molecular sensitivity of PET and thus increase its role in preclinical and clinical research as well as evaluating and managing disease in the clinic.

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“…Ils sont segmentés grâce à des électrodes déposées par photolithographie qui peuvent être de dimensions réduites [2][3][4]. Ils peuvent donc être divisés à l'aide d'électrodes segmentées en cellules élémentaires de détection à l'échelle du millimètre cube, voire moins, permettant une localisation tridimensionnelle fine des [5].…”

Section: Objectifsunclassified

TOPASE-MED : comment repenser l’imagerie TEP grâce aux détecteurs semiconducteurs

Montémont

Comtat

Descourt

et al. 2010

IRBM

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Study of a high resolution, 3-D positioning cross-strip Cadmium Zinc Telluride detector for PET

Cited by 11 publications

References 4 publications

Convex Optimization of Coincidence Time Resolution for a High-Resolution PET System

Convex Optimization of Coincidence Time Resolution for a High-Resolution PET System

Recent Developments in PET Instrumentation

TOPASE-MED : comment repenser l’imagerie TEP grâce aux détecteurs semiconducteurs

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