Study of acetylsalicylic acid electroreduction behavior at platinum electrode

Chrześcijańska, Ewa; Wudarska, Edyta; Kuśmierek, Elżbieta; Rynkowski, Jacek

doi:10.1016/j.jelechem.2013.11.015

Cited by 63 publications

(26 citation statements)

References 58 publications

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“…Within the potential range, where reduction peaks of the tested compounds appear, the supporting electrolyte (0.1 mol L -1 NaClO 4 ) shows no peaks (Fig. 2, curve 4) [22]. The voltammograms were also used in determination of half-wave potentials (E 1/2 ) of SA, ASA and AA reduction.…”

Section: Resultsmentioning

confidence: 99%

“…redox potential, half-wave potential, reduction currents, which can be used in calculation of kinetic parameters of electrode reactions like number of exchanged electrons, transfer coefficients, rate constants of electrode reactions. These parameters are important in estimation of anti-reductive properties of drugs as well as in understanding of their reduction mechanisms [18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

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Electroreduction of Salicylic Acid, Acetylsalicylic Acid and Pharmaceutical Products Containing these Compounds

Wudarska¹,

Chrześcijańska²,

Kuśmierek³

2014

Port. Electrochim. Acta

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Electroreduction properties of salicylic (SA) and acetylsalicylic (ASA) acids were investigated at platinum electrode using the voltammetry method. Cyclic voltammograms (CV) of the tested compounds were used in determining half-wave potential (E 1/2 ) -the parameter describing the anti-reductive properties. The content of active substances (SA and ASA) in the selected pharmaceuticals (salicylic alcohol, Bayer aspirin, etopirin and polopirin) was examined with the application of electrochemical and spectrophotometric methods.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electroreduction of Salicylic Acid, Acetylsalicylic Acid and Pharmaceutical Products Containing these Compounds

Wudarska¹,

Chrześcijańska²,

Kuśmierek³

2014

Port. Electrochim. Acta

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“…Electrochemistry using cyclic voltammetry has been known to be used in a wide variety of applications and characterization of materials 32 – 34 . Such as determining corrosion rate of metals and quantifying compounds in a given solution 34 – 36 .…”

Section: Discussionmentioning

confidence: 99%

Functionalized Non-vascular Nitinol Stent via Electropolymerized Polydopamine Thin Film Coating Loaded with Bortezomib Adjunct to Hyperthermia Therapy

Aguilar

Tumurbaatar

GhavamiNejad

et al. 2017

Sci Rep

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Gastrointestinal malignancies have been a tremendous problem in the medical field and cover a wide variety of parts of the system, (i.e. esophagus, duodenum, intestines, and rectum). Usually, these malignancies are treated with palliation with the use of non-vascular nitinol stents. However, stenting is not a perfect solution for these problems. While it can enhance the quality of life of the patient, in time the device will encounter problems such as re-occlusion due to the rapid growth of the tumor. In this study, we propose a functionalization technique using electropolymerization of polydopamine directly onto the nitinol stent struts for the combined application of hyperthermia and chemotherapy. The coating was characterized using FESEM, XPS, and FT-IR. Drug release studies show that facile release of the anticancer drug BTZ from the surface of the polydopamine-coated stent could be achieved by the dissociation between catechol groups of polydopamine and the boronic acid functionality of BTZ in a pH-dependent manner. The anti-cancer property was also evaluated, and cytotoxicity on ESO26 and SNU-5 cancer cell lines were observed. Our results suggest that the introduced approach can be considered as a potential method for therapeutic stent application.

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“…Initially, the phenoxy carboxylate radical was formed through one electron and two-proton oxidation. The phenoxy carboxylate radical underwent tautomerism and oxidation, forming 2-oxocyclohexa-3,5-dien-1-ylium carboxylate and 4-oxocyclohexa-2,5-dien-1-ylium carboxylate, which hydrolyzed to obtained 5-hydroxy-6-oxocyclohexa-1,3-dienecarboxylate and 3-hydroxy-6-oxocyclohexa-1,4-dienecarboxylate respectively, followed by the third oxidation by loss of one electron and two protons to form 5,6-dioxocyclohexa-1,3-dienecarboxylate and 3,6-dioxocyclohexa-1,4-dienecarboxylate (Scheme 1) [19][20][21][22]. In basic medium, SHAM was converted to ohydroxybenzoate ion (salicylate ion) as shown in Eq.…”

Section: Electrooxidation Of Sham In Artificial Saliva Solutionmentioning

confidence: 99%

Electrochemical oxidation of salicylhydroxamic acid on Pt electrode

El-Sayed

Salama

2016

Ovidius University Annals of Chemistry

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Abstract. The electrochemical oxidation behavior of salicylhydroxamic acid (SHAM) on a Pt electrode was investigated in aqueous solution of different pHs, containing 10 mM of SHAM, at 25 •C, by cyclic voltammetry technique. The results indicate that the SHAM was oxidized more easily in alkaline medium than acidic and neutral mediums, and the oxidation peaks of SHAM shifted toward lower potential values by increasing pH values. The SHAM electrooxidation involves an irreversible transfer of one or two electron, depending on the pH of solution. If solution pH is lower than 3 and higher than 7, the two electron transfer is involved in the electrooxidation. While, from pH=3 to pH=7, the SHAM electrooxidation involves an irreversible transfer of one electron and two protons in the first step, in agreement with the one step one-electron mechanism. The effect of SHAM concentration on the electrode reaction was investigated in artificial saliva solution. SHAM gives a single irreversible oxidation wave over the wide concentration range studied. Possible mechanism of SHAM electrooxidation was proposed.

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Study of acetylsalicylic acid electroreduction behavior at platinum electrode

Cited by 63 publications

References 58 publications

Electroreduction of Salicylic Acid, Acetylsalicylic Acid and Pharmaceutical Products Containing these Compounds

Electroreduction of Salicylic Acid, Acetylsalicylic Acid and Pharmaceutical Products Containing these Compounds

Functionalized Non-vascular Nitinol Stent via Electropolymerized Polydopamine Thin Film Coating Loaded with Bortezomib Adjunct to Hyperthermia Therapy

Electrochemical oxidation of salicylhydroxamic acid on Pt electrode

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